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Syntaxin 4 Proteine (STX4)

Bezeichnung:
Syntaxin 4 Proteine (STX4)
Auf www.antikoerper-online.de finden Sie aktuell 9 Syntaxin 4 (STX4) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Syntaxin 4 Antikörper (72) und Syntaxin 4 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 91 Syntaxin 4 Produkte verfügbar.
Synonyme:
CG2715, Dmel\\CG2715, DmSyx4, Dm Syx4, EG:95B7.1, EG:95B7.11, p35-2, Stx4, Stx4a, Syn-4, Syn4, syntaxin4, Syx, Syx-4, syx4
alle Proteine anzeigen Gen GeneID UniProt
STX4 6810 Q12846
Ratte STX4 STX4 81803 Q08850
STX4 20909 P70452

Weitere Synonyme anzeigen

Syntaxin 4 Proteine (STX4) nach Spezies

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Am meisten referenzierte Syntaxin 4 Proteine

  1. Human STX4 Protein expressed in Escherichia coli (E. coli) - ABIN1098360 : Yang, Coker, Kim, Mora, Thurmond, Davis, Yang, Williamson, Shulman, Pessin: Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. in The Journal of clinical investigation 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN1098360

Weitere Proteine zu Syntaxin 4 Interaktionspartnern

Human Syntaxin 4 (STX4) Interaktionspartner

  1. The analysis revealed three candidate genes GSK3B, PTPN1 (zeige PTPN1 Proteine), STX4 that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 (zeige PTPN1 Proteine) showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).

  2. When the expression of STX4 mRNA was inhibited with short or small interfering, or silencing, RNA in macrophages, the survival of Brucella melitensis was significantly reduced.

  3. Syntaxin-4 has a role in mediating exocytosis of pre-docked and newcomer insulin (zeige INS Proteine) granules underlying biphasic glucose-stimulated insulin (zeige INS Proteine) secretion in human pancreatic beta cells

  4. Increased level of SNAP23 (zeige SNAP23 Proteine)-Syntaxin4-VAMP7 (zeige VAMP7 Proteine) interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP (zeige MMP14 Proteine) to invadopodia during cellular invasion.

  5. upregulation of Syntaxin 4 is sufficient to significantly improve insulin (zeige INS Proteine) secretory function to human type 2 diabetes islets retaining low levels of residual function

  6. STX4 is implicated in the antibody secretion.

  7. Syntaxin-4 plays a vital role in exocytosis of IgE from plasma cells. Knock-down of syntaxin-4, but not VAMP3 dramatically reduced IgE secretion from U266 plasma cells causing it to accumulate in the cell.

  8. These results revealed, for the first time, the extracellular role of syntaxin4 and shed light on the division of the extracellular effects exerted by epimorphin (zeige STX2 Proteine) and syntaxin4 on keratinocyte cornification.

  9. Syntaxin 4 activation and insulin (zeige INS Proteine) release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis

  10. Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons.

Mouse (Murine) Syntaxin 4 (STX4) Interaktionspartner

  1. Syn4 transgenic mice with high level expression of Syn4 had a significant extension of lifespan (33% increase in median) and showed increased peripheral insulin (zeige INS Proteine) sensitivity, even at ages where controls exhibited age-related insulin (zeige INS Proteine) resistance.

  2. Non-directional stimulation with extracellular syntaxin-4 induces a dramatic morphological change in teratocarcinoma F9 cells and in several endodermal markers, both of which effects are reminiscent of the cells treated with all-trans retinoic acid.

  3. Delivery of GLUT4 (zeige SLC2A4 Proteine) to the plasma membrane is mediated by formation of functional SNARE (zeige VTI1B Proteine) complexes containing syntaxin4, SNAP23 (zeige SNAP23 Proteine), and VAMP2 (zeige VAMP2 Proteine).

  4. data support a mechanistic model for gelsolin's role in insulin (zeige INS Proteine) exocytosis: gelsolin (zeige GSN Proteine) clamps unsolicited soluble N-ethylmaleimide-sensitive factor (zeige NSF Proteine) attachment receptor-regulated exocytosis through association with Syn4 which is relieved upon stimulus-induced calcium influx to activate gelsolin (zeige GSN Proteine) to facilitate insulin (zeige INS Proteine) exocytosis

  5. Syntaxin 4 activation and insulin (zeige INS Proteine) release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis

  6. functions as the necessary t-SNARE (zeige VTI1B Proteine) protein responsible for correct fusion of the GLUT8 (zeige SLC2A8 Proteine)-containing vesicle with the plasma membrane in the mouse blastocyst

  7. Interacts with tomosyn (zeige STXBP5 Proteine) and plays a role in insulin (zeige INS Proteine)-stimulated GLUT4 (zeige SLC2A4 Proteine) translocation.

  8. female Syn4 transgenic mice exhibited an increased rate of glucose clearance during glucose tolerance tests that was repressible by the administration of tetracycline

  9. Data show that Munc18c (zeige STXBP3 Proteine) binds to monomeric syntaxin4 and the N-terminal 29 amino acids of syntaxin4 are necessary for this interaction.

  10. One mechanism accounting for the PDGF (zeige PDGFA Proteine) induction of Glut4 (zeige SLC2A4 Proteine) translocation is the suppression of the Munc18c (zeige STXBP3 Proteine) negative regulation of Syntaxin 4 function.

Syntaxin 4 (STX4) Protein Überblick

Protein Überblick

Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity).

Alternative names and synonyms associated with Syntaxin 4 (STX4)

  • Syntaxin 4 (Syx4)
  • syntaxin 4 (STX4)
  • syntaxin 4 (stx4)
  • syntaxin 4 (Stx4)
  • syntaxin 4A (placental) (Stx4a)
  • CG2715 Protein
  • Dmel\\CG2715 Protein
  • DmSyx4 Protein
  • Dm Syx4 Protein
  • EG:95B7.1 Protein
  • EG:95B7.11 Protein
  • p35-2 Protein
  • Stx4 Protein
  • Stx4a Protein
  • Syn-4 Protein
  • Syn4 Protein
  • syntaxin4 Protein
  • Syx Protein
  • Syx-4 Protein
  • syx4 Protein

Bezeichner auf Proteinebene für Syntaxin 4 Proteine (STX4)

CG2715-PA , CG2715-PB , Syx4-PA , Syx4-PB , syntaxin , syntaxin 4 , renal carcinoma antigen NY-REN-31 , syntaxin 4A (placental) , syntaxin-4

GENE ID SPEZIES
31269 Drosophila melanogaster
489919 Canis lupus familiaris
493473 Xenopus (Silurana) tropicalis
734915 Xenopus laevis
6810 Homo sapiens
81803 Rattus norvegicus
508675 Bos taurus
20909 Mus musculus
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