SNCA Proteine (SNCA)

Bezeichnung:
Synuclein, alpha Proteine (SNCA)
Auf www.antikoerper-online.de finden Sie aktuell 75 Synuclein, alpha (SNCA) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SNCA Antikörper (753) und SNCA Kits (70) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 923 SNCA Produkte verfügbar.
Synonyme:
alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca
alle Proteine anzeigen Gen GeneID UniProt
SNCA 20617 O55042
SNCA 6622 P37840
SNCA 29219 P37377

Weitere Synonyme anzeigen

SNCA Proteine (SNCA) nach Spezies

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Am meisten referenzierte SNCA Proteine

  1. Mouse (Murine) SNCA Protein expressed in Escherichia coli (E. coli) - ABIN667142 : Kim: Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. in Molecules and cells 1997 (PubMed)
    Zeige alle 3 Referenzen für 667142

  2. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN1046507 : Uéda, Fukushima, Masliah, Xia, Iwai, Yoshimoto, Otero, Kondo, Ihara, Saitoh: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Zeige alle 3 Referenzen für 1046507

  3. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039 : Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 2 Referenzen für 2005039

  4. Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284 : Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005 (PubMed)

Weitere Proteine zu SNCA Interaktionspartnern

Xenopus laevis Synuclein, alpha (SNCA) Interaktionspartner

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (zeige SNCG PLURAL_@41748@)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) Interaktionspartner

  1. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  2. LRRK2 (zeige LRRK2 Proteine) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (zeige LRRK2 Proteine) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.

  3. sideroflexin 3 (SFXN3 (zeige SFXN3 Proteine)) was found to be a mitochondrial protein (zeige COX6B2 Proteine) localized to the inner mitochondrial membrane.

  4. The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation

  5. Rab7 (zeige RAB7A Proteine) accumulated in GCase (zeige GBA Proteine) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA Proteine) can reverse ALR (zeige GFER Proteine) impairment, we anticipate that strategies to restore GCase (zeige GBA Proteine) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA Proteine) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.

  6. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (zeige TLR4 Proteine)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 (zeige PINK1 Proteine) can protect the immature brain against cell apoptosis induced by LPS (zeige TLR4 Proteine)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (zeige TLR4 Proteine)-sensitized HI brain damage in PINK1 (zeige PINK1 Proteine)-knockout neonatal mice

  7. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  8. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (zeige PRNP Proteine)-like conversion.

  9. In summary, we have combined multiple data sets to identify transcripts, which are strong candidates for being phenotypic modifiers, and demonstrated SNCA is a modifier of pathology in motor neuron disease.

  10. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

Human Synuclein, alpha (SNCA) Interaktionspartner

  1. Study suggests histones as prime candidates for one of the nuclear proaggregant factors involved in the formation of transmissible alpha-synuclein aggregates during neuron apoptosis.

  2. Study provides evidence that phosphorylated alpha-synuclein deposition is present in dermal nerve fibers in a subgroup of patients suffering from REM (zeige REM1 Proteine) sleep behavior disorder, presumably representing prodromal Parkinson's disease.

  3. This review describes the major findings supporting the occurrence of alpha-synuclein pathology propagation in Parkinson's disease and discusses how this phenomenon could induce or contribute to synaptic injury and degeneration. [Review]

  4. This review evaluated major classes of molecular chaperones and their mechanisms relevant for preventing protein aggregation, specific case of alpha-synuclein aggregation. [review]

  5. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  6. Data suggest that endocytosis and lysosomal processing of proteopathic alpha-synuclein aggregates in neurons are consistent with models of neurodegeneration in synucleinopathies. [EDITORIAL]

  7. These results indicate that LRRK2 (zeige LRRK2 Proteine) and alpha-synuclein participate in the dysregulation of CADPS2 (zeige CADPS2 Proteine) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  8. Increasing evidence supports that small alpha-synuclein aggregates or oligomers may be the real culprit, causing deficits in neurotransmission and neurogenesis in the hippocampus and related brain regions, which constitute the major mechanism for the hippocampal dysfunctions and associated neuropsychiatric manifestations in synucleinopathies. [alpha-synuclein]

  9. Most anti-PD1 (zeige PDCD1 Proteine)-related adrenal insufficiency cases involved an isolated ACTH (zeige POMC Proteine) deficiency. Eosinophilia may be an early indicator before the onset of symptoms.

  10. Significantly higher transcript expression levels of PD1 (zeige PDCD1 Proteine) were found in tumor tissue, whilst a general increase in PDL1 (zeige CD274 Proteine) expression was found in tumor tissues, although this did not reach statistical significance. Our study demonstrates higher levels of expression of PDL1 (zeige CD274 Proteine) are associated with favorable clinical outcome.

Cow (Bovine) Synuclein, alpha (SNCA) Interaktionspartner

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (zeige TNFAIP1 Proteine) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Protein Überblick

Protein Überblick

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Alternative names and synonyms associated with SNCA

  • synuclein, alpha (snca)
  • alpha-synuclein (LOC619283)
  • alpha-synuclein (LOC100359228)
  • synuclein, alpha (Snca)
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA)
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca)
  • alphaSYN Protein
  • LOC619283 Protein
  • MGC64356 Protein
  • NACP Protein
  • PARK1 Protein
  • PARK4 Protein
  • PD1 Protein
  • snca Protein

Bezeichner auf Proteinebene für Synuclein, alpha Proteine (SNCA)

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

GENE ID SPEZIES
380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
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