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SNCA Proteine (SNCA)

Synuclein, alpha Proteine (SNCA)
Auf finden Sie aktuell 72 Synuclein, alpha (SNCA) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SNCA Antikörper (647) und SNCA Kits (68) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 812 SNCA Produkte verfügbar.
alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca
alle Proteine anzeigen Gen GeneID UniProt
SNCA 20617 O55042
SNCA 6622 P37840
SNCA 29219 P37377

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SNCA Proteine (SNCA) nach Spezies

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Am meisten referenzierte SNCA Proteine

  1. Mouse (Murine) SNCA Protein expressed in Escherichia coli (E. coli) - ABIN667142 : Kim: Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. in Molecules and cells 1997 (PubMed)
    Zeige alle 3 Referenzen für ABIN667142

  2. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN1046507 : Uéda, Fukushima, Masliah, Xia, Iwai, Yoshimoto, Otero, Kondo, Ihara, Saitoh: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Zeige alle 3 Referenzen für ABIN1046507

  3. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039 : Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 2 Referenzen für ABIN2005039

  4. Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284 : Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005 (PubMed)

Weitere Proteine zu SNCA Interaktionspartnern

Xenopus laevis Synuclein, alpha (SNCA) Interaktionspartner

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (zeige SNCG Proteine)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) Interaktionspartner

  1. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (zeige TLR4 Proteine)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 (zeige PINK1 Proteine) can protect the immature brain against cell apoptosis induced by LPS (zeige TLR4 Proteine)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (zeige TLR4 Proteine)-sensitized HI brain damage in PINK1 (zeige PINK1 Proteine)-knockout neonatal mice

  2. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  3. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (zeige PRNP Proteine)-like conversion.

  4. In summary, we have combined multiple data sets to identify transcripts, which are strong candidates for being phenotypic modifiers, and demonstrated SNCA is a modifier of pathology in motor neuron disease.

  5. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

  6. alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.

  7. In the olfactory bulb, globus pallidus and substantia nigra pars compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.

  8. identified alpha-synuclein as a new transcriptional target of p53 (zeige TP53 Proteine)

  9. High SNCA expression is associated with epilepsy.

  10. Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.

Human Synuclein, alpha (SNCA) Interaktionspartner

  1. Molecular structure of pathogenic fibrils formed by the human alpha-synuclein, resolved by NMR spectroscopy.

  2. Data suggest that alpha-synuclein exhibits ferrireductase activity; the major catalytically active form is a putative membrane-associated tetramer; models suggests a mechanistic rationale for the activity and the relationship to cellular regulation of the pool of Fe(III) and Fe(II).

  3. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  4. aggregating proteins, such as amyloid-beta (Abeta (zeige APP Proteine)) and alpha-synuclein (alpha-syn), proteins associated with Alzheimer's disease and synucleinopathies, respectively, share similar biophysical and biochemical properties with PrP (zeige C4BPA Proteine)(Sc) that influences

  5. detected alpha synuclein in the gastrointestinal tract of patients up to 20 years prior to their Parkinson disease diagnosis.

  6. Study provides Class III evidence that p-alpha-syn skin deposits identify patients with idiopathic REM (zeige REM1 Proteine) sleep behavior disorder, suggests that immunohistochemical analysis of p-alpha-syn in skin samples may be a promising safe and inexpensive marker

  7. findings suggest that, at least in Mexican Mestizos, allelic variants of the rs1801133 and rs3857059 in MTHFR and SNCA genes account for susceptibility to Parkinson's disease and the GG genotype of the rs3857059 variant is particularly associated with PD in females of this population.

  8. This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (zeige CRYAB Proteine) (alphaB-c) and Hsp27 (zeige HSPB1 Proteine), interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation

  9. Results indicate that V63 and N65 amino acid residues of alpha-synuclein are critical residues mediating mitochondrial inactivation. These findings provide novel insight into the molecular events contributing to Parkinson disease pathogenesis.

  10. This study demonstrates that SNCA rs356182 variant has an increased risk of susceptibility to PD in Han Chinese population.

Cow (Bovine) Synuclein, alpha (SNCA) Interaktionspartner

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (zeige TNFAIP1 Proteine) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Protein Überblick

Protein Überblick

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Alternative names and synonyms associated with SNCA

  • synuclein, alpha (snca)
  • alpha-synuclein (LOC619283)
  • alpha-synuclein (LOC100359228)
  • synuclein, alpha (Snca)
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA)
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca)
  • alphaSYN Protein
  • LOC619283 Protein
  • MGC64356 Protein
  • NACP Protein
  • PARK1 Protein
  • PARK4 Protein
  • PD1 Protein
  • snca Protein

Bezeichner auf Proteinebene für Synuclein, alpha Proteine (SNCA)

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
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