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Developmental gene expression pattern of reelin, dab1 (zeige DAB1 Proteine), vldlr (zeige VLDLR Proteine), and apoer2 (zeige LRP8 Proteine) in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.
Sex-associated and brain region-specific differences in reelin expression appear long before Abeta (zeige APP Proteine)-plaque formation in AbetaPP mutant Alzheimer disease model.
These findings suggest that circulating Reelin promotes atherosclerosis by increasing vascular inflammation, and that reducing or inhibiting circulating Reelin may present a novel approach for the prevention of cardiovascular disease.
A new transgenic mouse model demonstrates that Reelin is a molecule which is critical for proper cortical development.
androgenic hormones can influence cerebral reelin demethylation
data suggest Kdm5b (zeige KDM5B Proteine) negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone.
reveals a novel function for Reelin/ApoER2 (zeige LRP8 Proteine) in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
Reelin thus plays a role in restraining RAS and PI3-kinase (zeige PIK3CA Proteine) promotion of cell motility and potentially tumour metastasis.
meprin alpha (zeige MEP1A Proteine) and meprin beta (zeige MEP1B Proteine) join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.
reelin and cofilin (zeige CFL1 Proteine) cooperate in controlling cytoskeletal dynamics during neuronal migration.
Results suggest that Reelin induces branching of the leading processes of migrating neurons and that of basal processes of radial glial cells when they arrive at the Reelin-containing marginal zone.
Reelin signaling is a critical player in the modulation of synaptic function.
Reelin was expressed by human hepatic stellate cells/myofibroblasts and the number of these cells increased significantly in the lobule as the liver fibrosis progressed, suggesting a role for Reelin in the activation of hepatic stellate cells/myofibroblasts during liver injury.
The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR (zeige VLDLR Proteine) presented positive values in 16 cases (16/ 32) and ApoER2 (zeige LRP8 Proteine) was weak positive in 7 cases.
common variants of GABRG2 (zeige GABRG2 Proteine), RELN and NRG3 (zeige NRG3 Proteine) and the GABRG2 (zeige GABRG2 Proteine)-RELN-PTCH1 (zeige PTCH1 Proteine) interaction networks might confer altered susceptibility to Hirschsprung disease.
RELN is mapped at 7q22, which had been identified as a candidate region for autism by early genetic linkage study.
reelin promotes multiple myeloma cell adhesion, survival, and drug resistance via activation of integrin alpha5beta1.
Among men, but not in women certain genotypes of the RELN gene were significantly associated with the susceptibility to Alzheimer's disease.
Report demonstrated that the reelin subregion R5-6 consisting of 747 amino acids in the 5th and 6th repeats was sufficient for apoER2 (zeige LRP8 Proteine) and VLDLR (zeige VLDLR Proteine) binding, and inhibiting lipoprotein-induced cholesterol accumulation in macrophages.
A peak in Reelin mRNA and protein expression is present in the pig embryonic brain during the period of major neurogenesis and neuronal migration.
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
, extracellular matrix serine protease
, reelin, extracellular