Protoporphyrinogen Oxidase Proteine (PPOX)

Protoporphyrinogen Oxidase Proteine (PPOX)
Auf finden Sie aktuell 9 Protoporphyrinogen Oxidase (PPOX) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Protoporphyrinogen Oxidase Antikörper (56) und Protoporphyrinogen Oxidase Kits (16) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 85 Protoporphyrinogen Oxidase Produkte verfügbar.
BcDNA:LD41392, CG5796, Dmel\\CG5796, ESTS:9F2T, hemG, HEMG1, Ppo, PPO1, PPOX, PROTOPORPHYRINOGEN OXIDASE, TC0121, V290M, VP, zgc:123252
alle Proteine anzeigen Gen GeneID UniProt
PPOX 15171 O55241
PPOX 5498 P50336
PPOX 289219  

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Mouse (Murine) Protoporphyrinogen Oxidase (PPOX) Interaktionspartner

  1. In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.

  2. OXA and OX1R (zeige HCRTR1 Proteine) are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.

  3. Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R (zeige HCRTR1 Proteine) signaling cascade due to decreased OX1R (zeige HCRTR1 Proteine) expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.

  4. Binding of OXA to OX1R (zeige HCRTR1 Proteine) is important for the development of the testis.

  5. Results suggest that orexin A bidirectionally modulates hippocampal CA1 (zeige CA1 Proteine) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (zeige PLC Proteine) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations

  6. DYN-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.

  7. Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin/hypocretin networks have been discovered.

  8. Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency

  9. observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.

  10. Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (zeige PMCH Proteine) neural systems in the basolateral amygdala

Human Protoporphyrinogen Oxidase (PPOX) Interaktionspartner

  1. GAPDH (zeige GAPDH Proteine) and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH (zeige GAPDH Proteine) or PPOX reduced the growth of colon cancer cells in vitro

  2. Variegate porphyria is the result of decreased protoporphyrinogen oxidase activity. Diet supplementation with vitamins E and C restores PPOX gene expression in lymphocytes of variegate porphyria patients.

  3. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS (zeige HMBS Proteine)

  4. The c.851G>T and the c.1013C>G of PPOX gene were found in two and four unrelated families respectively. 1 experienced only photosensitivity, 1 only neurological symptoms and the 2 both clinical manifestations.

  5. The mutation 1082-1083insC(1 base pair insertion at position 1082) in exon 10 of the PPOX gene was prevalent in the Swiss population.

  6. findings emphasize the usefulness of MLPA analysis as a complement to PPOX gene sequencing analysis for comprehensive genetic diagnostics in patients with variegate prophyria

  7. Information required for targeting to the mitochondria is contained within the first 250 amino acid residues of human PPOX.

  8. Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using PPOX.

  9. Protoporphyrinogen oxidase targeting mechanism to the mitochondrion.

  10. Mutation in protoporphyrinogen oxidase is associated with variegate porphyria

Arabidopsis thaliana Protoporphyrinogen Oxidase (PPOX) Interaktionspartner

  1. The tetrapyrrole biosynthetic enzyme PPO1 is required for plastid RNA editing.

Protoporphyrinogen Oxidase (PPOX) Protein Überblick

Protein Überblick

This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Protoporphyrinogen Oxidase (PPOX)

  • Protoporphyrinogen oxidase (Ppox)
  • protoporphyrinogen oxidase (ppox)
  • protoporphyrinogen oxidase (hemY)
  • protoporphyrinogen oxidase (Mrub_1406)
  • protoporphyrinogen oxidase (Mesil_2992)
  • protoporphyrinogen oxidase (Trad_0583)
  • protoporphyrinogen oxidase (Calni_0746)
  • protoporphyrinogen oxidase (Ocepr_1049)
  • protoporphyrinogen oxidase (Tmar_0766)
  • protoporphyrinogen oxidase (Intca_1907)
  • protoporphyrinogen oxidase (Despr_0642)
  • protoporphyrinogen oxidase (Plabr_2407)
  • protoporphyrinogen oxidase (Deipr_2130)
  • protoporphyrinogen oxidase (Hipma_0622)
  • hypocretin (Hcrt)
  • protoporphyrinogen oxidase (Ppox)
  • protoporphyrinogen oxidase (PPOX)
  • BcDNA:LD41392 Protein
  • CG5796 Protein
  • Dmel\\CG5796 Protein
  • ESTS:9F2T Protein
  • hemG Protein
  • HEMG1 Protein
  • Ppo Protein
  • PPO1 Protein
  • PPOX Protein
  • TC0121 Protein
  • V290M Protein
  • VP Protein
  • zgc:123252 Protein

Bezeichner auf Proteinebene für PPOX

protoporphyrinogen oxidase , CG5796-PA , Ppox-PA , protoporphyrinogen-oxidase , mno , montalcino , ppo , orexin , orexin A , orexin B , prepro-orexin , protoporhyrinogen oxidase

42939 Drosophila melanogaster
664750 Danio rerio
887711 Mycobacterium tuberculosis H37Rv
894184 Bacillus halodurans C-125
910131 Mycobacterium leprae TN
1017310 Oceanobacillus iheyensis HTE831
1121814 Staphylococcus aureus subsp. aureus Mu50
1245655 Chlamydia muridarum Nigg
2860707 Staphylococcus aureus subsp. aureus MRSA252
3204574 Bacillus clausii KSM-K16
3958489 Chlamydophila felis Fe/C-56
5331016 Staphylococcus aureus subsp. aureus str. Newman
5560658 Staphylococcus aureus subsp. aureus Mu3
6226299 Mycobacterium marinum M
7324674 Mycobacterium leprae Br4923
7550597 Staphylococcus carnosus subsp. carnosus TM300
8767366 Bacillus pseudofirmus OF4
8879503 Meiothermus ruber DSM 1279
9252515 Meiothermus silvanus DSM 9946
9279560 Truepera radiovictrix DSM 17093
10008757 Calditerrivibrio nitroreducens DSM 19672
10015901 Oceanithermus profundus DSM 14977
10081140 Thermaerobacter marianensis DSM 12885
10084727 Intrasporangium calvum DSM 43043
10173352 Desulfobulbus propionicus DSM 2032
10239818 Planctomyces brasiliensis DSM 5305
10265450 Deinococcus proteolyticus MRP
10391952 Hippea maritima DSM 10411
15171 Mus musculus
19044 Mus musculus
5498 Homo sapiens
478980 Canis lupus familiaris
515770 Bos taurus
289219 Rattus norvegicus
100153636 Sus scrofa
100340158 Oryctolagus cuniculus
827991 Arabidopsis thaliana
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