Neurexin 1 Proteine (NRXN1)

Bezeichnung:
Neurexin 1 Proteine (NRXN1)
Auf www.antikoerper-online.de finden Sie aktuell 11 Neurexin 1 (NRXN1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Neurexin 1 Antikörper (64) und Neurexin 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 86 Neurexin 1 Produkte verfügbar.
Synonyme:
1700062G21Rik, 9330127H16Rik, A230068P09Rik, CG7050, CT21808, Dmel\\CG7050, dnrx, dnrx-1, GB13455, GB18754, Hs.22998, mKIAA0578, nrx, Nrx-1, Nrx1, NRXN1, Nrxn1b, PTHSL2, SCZD17
alle Proteine anzeigen Gen GeneID UniProt
Ratte NRXN1 NRXN1 60391 Q63372
NRXN1 9378 Q9ULB1 , P58400
NRXN1 18189 Q9CS84

Weitere Synonyme anzeigen

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Weitere Proteine zu Neurexin 1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Neurexin 1 (NRXN1) Interaktionspartner

  1. Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1)

  2. DNRX was expressed preferentially in central and motor neurons in embryos, larvae and adults, but not in glial cells. DNRX was expressed in pre- and post-synaptic areas in third instar larvae neuromuscular junctions.

  3. presynaptic spinophilin (zeige PPP1R9B Proteine) fine-tunes neurexin/neuroligin signalling to control active zone number and functionality

  4. The intracellular region of NRX interacts with N-ethylmaleimide-sensitive factor (zeige NSF Proteine). This interaction regulates short term synaptic depression.

  5. cooperation between Syd-1 and Nrx-1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes

  6. Neurexin-1 null mutants exhibit associative learning defect in larvad.

  7. DNRX is essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ).

Human Neurexin 1 (NRXN1) Interaktionspartner

  1. that alpha-Neurexin binding to alpha2delta of N-type calcium channels is a conserved mechanism for regulating synaptic transmission

  2. NRXN1 copy number variants (deletions) were associated with increased risk of Tourette syndrome.

  3. MDGAs regulate the formation of neuroligin-neurexin trans-synaptic bridges by sterically blocking access of neurexins to neuroligins.

  4. In a Mexican Mestizo population, greater consumption of cigarettes was influenced by polymorphisms in the NRXN1 and CHRNA5 genes.

  5. Results demonstrate that NRXN1 alternative isoform expression is temporally regulated during critical periods of human neocortical development and identify potential differential molecular contributions of NRXN1-alpha and -beta to schizophrenia and bipolar disorder

  6. the top-ranked discordances were subsequently selected for validation by quantitative polymerase chain reaction (qPCR), from which one single ~120kb deletion in NRXN1 on chromosome 2 (bp 51017111-51136802) was validated

  7. Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 (zeige HOXA13 Proteine) and NRXN1

  8. The rare variants in NRXN1 were significantly associated with smoking status.

  9. NRXN1 has an affinity for binding to LRRTM2 (zeige LRRTM2 Proteine) in hippocampal synapses.

  10. heterozygous inactivation of NRXN1 directly impairs synaptic function in human neurons.

Cow (Bovine) Neurexin 1 (NRXN1) Interaktionspartner

  1. The structure of neurexin 1alpha reveals features promoting a role as synaptic organizer

  2. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function

  3. crystallographic analysis of the second LNS/LG domain from neurexin 1alpha

Mouse (Murine) Neurexin 1 (NRXN1) Interaktionspartner

  1. After pan-neurexin deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin (zeige PVALB Proteine)-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2 (zeige CA2 Proteine)+) transients (somatostatin (zeige SST Proteine)-positive synapses).

  2. Findings demonstrate that the heterozygous loss of alpha-neurexin I and alpha-neurexin II (zeige NRXN2 Proteine) in mice leads to phenotypes relevant to autism and schizophrenia

  3. Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.

  4. Nlgn3 (zeige NLGN3 Proteine) and Nrxn1 are differentially expressed in cerebral cortex and hippocampus which might be responsible for alterations in synaptic plasticity during agine.

  5. Thus our data suggest that perinatal exposure to BPA (zeige DST Proteine) impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 and Nlgn3 (zeige NLGN3 Proteine) and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.

  6. Mutant neurexin-1beta expression in mouse adult brain leads to core autism symptoms.

  7. neurexin 1 interaction with multi-PDZ domain protein MUPP1

  8. Deletions within NRXN1 found in patients may be responsible for the impairments seen in social behaviours and Nrxn1alpha knockout mice are a useful model of human neurodevelopmental disorders.

  9. Nrxn1 and Nlgn (zeige NLGN4X Proteine) genes that may represent an important aspect of their function at synapses in health and disease

  10. Cross-species co-expression and protein interaction network analyses identify glycogen synthase kinase 3 beta (GSK3B) as one of the most consistent and conserved covariates of NRXN1.

Neurexin 1 (NRXN1) Protein Überblick

Protein Überblick

Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms\; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.

Alternative names and synonyms associated with Neurexin 1 (NRXN1)

  • neurexin 1 (NRXN1)
  • Neurexin 1 (Nrx-1)
  • neurexin 1 (Nrx-1)
  • neurexin 1 (nrxn1)
  • neurexin 1 (Nrxn1)
  • neurexin I (Nrxn1)
  • 1700062G21Rik Protein
  • 9330127H16Rik Protein
  • A230068P09Rik Protein
  • CG7050 Protein
  • CT21808 Protein
  • Dmel\\CG7050 Protein
  • dnrx Protein
  • dnrx-1 Protein
  • GB13455 Protein
  • GB18754 Protein
  • Hs.22998 Protein
  • mKIAA0578 Protein
  • nrx Protein
  • Nrx-1 Protein
  • Nrx1 Protein
  • NRXN1 Protein
  • Nrxn1b Protein
  • PTHSL2 Protein
  • SCZD17 Protein

Bezeichner auf Proteinebene für Neurexin 1 Proteine (NRXN1)

CG7050-PA , CG7050-PB , CG7050-PC , CG7050-PD , CG7050-PE , CG7050-PF , CG7050-PG , CG7050-PH , Neurexin-1 , Neurexin-like , Nrx-1-PA , Nrx-1-PB , Nrx-1-PC , Nrx-1-PD , Nrx-1-PE , Nrx-1-PF , Nrx-1-PG , Nrx-1-PH , drosophila neurexin , neurexin , neurexin 1 , neurexin 1 alpha , neurexin 1 beta , neurexin-1-beta isoform alpha1 , neurexin-1-beta isoform alpha2 , neurexin I-like , neurexin-1-alpha-like , neurexin I-alpha , neurexin I-beta , neurexin-1-alpha , neurexin-1-beta , non-processed neurexin I-alpha , neurexin I , neurexin-1 , neurexin I alpha , alpha-latrotoxin receptor (calcium-dependent)

GENE ID SPEZIES
781054 Sus scrofa
42646 Drosophila melanogaster
459224 Pan troglodytes
619185 Macaca mulatta
724217 Apis mellifera
100052908 Equus caballus
100127647 Xenopus (Silurana) tropicalis
100349063 Oryctolagus cuniculus
100466581 Ailuropoda melanoleuca
100567183 Anolis carolinensis
60391 Rattus norvegicus
9378 Homo sapiens
474589 Canis lupus familiaris
281950 Bos taurus
395398 Gallus gallus
100622083 Sus scrofa
18189 Mus musculus
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