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TTBK2 (zeige TTBK2 Proteine) down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5 (zeige RAB5A Proteine)-dependent endocytosis.
In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility.
Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 (zeige GRIK1 Proteine) and GluK2) with the Neto1 (zeige NETO1 Proteine) and Neto2 (zeige NETO2 Proteine) auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner
This study found in GRIK2 (glutamate (zeige GRIN1 Proteine) receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression.
This study showed that Gluk2 association with obsessive-compulsive disorder.
Parkin interac (zeige PARK2 Proteine)ts with the kainate receptor GluK2 subunit and regulates KAR function.
High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars.
The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src (zeige SRC Proteine) family kinases, which may be of pathological significance in ischemic stroke.
we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients
14-3-3 (zeige YWHAQ Proteine) proteins are an important regulator of GluK2a-containing KARs (zeige KARS Proteine) and may contribute to the slow decay kinetics of native KAR (zeige HSD17B12 Proteine)-EPSCs.
The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4 (zeige GRIK4 Proteine)/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
GluK2-mediated increase in KCC2 (zeige SLC12A5 Proteine) recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).
Loss of parkin (zeige PARK2 Proteine) function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane.
Interictal and ictal discharges are minimized in mice lacking the GluK2 subunit.
This study demonistrated that grik2 gene expression in mouse dorsal raphe nucleus
The results show that NETO2 (zeige NETO2 Proteine) is a kainate receptor subunit with significant effects on glutamate (zeige GRIN1 Proteine) signaling mechanisms in brain.
GluR6 kainate receptors are critically involved in inhibiting transmission at both A delta and C fibre monosynaptic pathways. Presynaptic GluR5 (zeige GRIK1 Proteine) kainate receptors play limited role in inhibiting C fibre-activated pathway.
Using kainate receptor knock-out mice, we show that subunits glutamate (zeige GRIN1 Proteine) receptor (GluR) 5 (zeige GRIK1 Proteine) and GluR6 play distinct roles in kainate-induced gamma oscillations and epileptiform burst activity.
The facilitatory effects of kainate on mossy fiber synaptic transmission and plasticity are mediated by GLU (zeige GCG Proteine)(K6)-containing kainate receptors.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
glutamate receptor 6
, glutamate receptor, ionotropic kainate 2
, glutamate receptor, ionotropic, kainate 5
, excitatory amino acid receptor 4
, glutamate receptor form A
, glutamate receptor form B
, glutamate receptor form C
, glutamate receptor form D
, glutamate receptor form E
, glutamate receptor ionotropic, kainate 2
, gluR beta-2
, glutamate receptor beta-2
, glutamate receptor, ionotropic, kainate 2