ZFP36L2 Proteine (ZFP36L2)

Zinc Finger Protein 36, C3H Type-Like 2 Proteine (ZFP36L2)
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Brf2, c3h-3, ERF-2, ERF2, fi22c11, RNF162C, Tis11d, wu:fi22c11, XC3H-3b, ZFP36L2, zgc:76924
alle Proteine anzeigen Gen GeneID UniProt
ZFP36L2 678 P47974
ZFP36L2 12193  
Ratte ZFP36L2 ZFP36L2 298765  

Weitere Synonyme anzeigen

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Weitere Proteine zu ZFP36L2 Interaktionspartnern

Human Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) Interaktionspartner

  1. silencing ZFP36L2 inhibited cancer cell aggressiveness in pancreatic ductal adenocarcinoma cell lines, and overexpression of ZFP36L2 was confirmed in pancreatic ductal adenocarcinoma clinical specimens

  2. Study of the role of the C-terminal residues in the structure of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E220) using molecular dynamics, NMR spectroscopy, and biochemical methods

  3. The roles of TTP (zeige ADAMTS13 Proteine) and BRF (zeige BRF1 Proteine) proteins in regulated mRNA decay.

  4. Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia.

  5. ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.

  6. Multiple nanosecond timescale molecular dynamics trajectories of TIS11d wild-type and E157R/E195K mutant with different RNA sequences were performed to investigate the molecular basis for RNA binding specificities of this TZF domain.

  7. polymorphisms sequenced in genomic DNA encoding the TTP (zeige ADAMTS13 Proteine) protein (ZFP36 (zeige ZFP36 Proteine)) and those of its two known mammalian relatives, ZFP36L1 (zeige ZFP36L1 Proteine) and ZFP36L2, from 72 to 92 anonymous human subjects from various geographical and ethnic backgrounds

  8. Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases

  9. These data suggest TIS11D as a candidate p53 (zeige TP53 Proteine) target gene that may be part of the network of genes responsible for p53 (zeige TP53 Proteine)-dependent apoptosis.

Mouse (Murine) Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) Interaktionspartner

  1. ZFP36L1 (zeige ZFP36L1 Proteine) and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.

  2. In mature peripheral neurons, ZFP36L2 mediates post-transcriptional mechanisms by promoting axonal integrity.

  3. lack of the physiological down regulation of luteinizing hormone receptor (zeige LHCGR Proteine) mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest

  4. ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subsequent increase in the total numbers of colony-forming unit-erythroid (CFU-E) progenitors and erythroid cells that are generated

  5. Data revealed that ZFP36L1 (zeige ZFP36L1 Proteine) and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1 (zeige DUSP1 Proteine)) mRNA and downregulated Mkp-1 (zeige DUSP1 Proteine) 3'UTR-mediated luciferase activity.

  6. ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor.

  7. model of disruption of the earliest stages of embryogenesis, implicating Zfp36l2, a probable mRNA-binding and destabilizing protein, in the physiological control of female fertility at the level of early embryonic development

  8. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

ZFP36L2 Protein Überblick

Protein Überblick

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.

Alternative names and synonyms associated with ZFP36L2

  • zinc finger protein 36, C3H type-like 2 (zfp36l2)
  • zinc finger protein 36, C3H type-like 2 (ZFP36L2)
  • Butyrate response factor 2 (tisd)
  • ZFP36 ring finger protein-like 2 (zfp36l2)
  • ZFP36 ring finger protein-like 2 (ZFP36L2)
  • zinc finger protein 36, C3H type-like 2 (Zfp36l2)
  • Brf2 Protein
  • c3h-3 Protein
  • ERF-2 Protein
  • ERF2 Protein
  • fi22c11 Protein
  • RNF162C Protein
  • Tis11d Protein
  • wu:fi22c11 Protein
  • XC3H-3b Protein
  • ZFP36L2 Protein
  • zgc:76924 Protein

Bezeichner auf Proteinebene für ZFP36L2

butyrate response factor 2 , zinc finger protein 36, C3H type-like 2 , Butyrate response factor 2 , zinc finger protein 36, C3H1 type-like 2 , EGF-response factor 2 , ZFP36-like 2 , zinc finger protein 36, C3H type-like 1 , zinc finger protein, C3H type, 36-like 2 , zinc finger protein 36, C3H type-like 2-like

333941 Danio rerio
459185 Pan troglodytes
100195240 Salmo salar
100125029 Xenopus (Silurana) tropicalis
100524530 Sus scrofa
100599224 Nomascus leucogenys
678 Homo sapiens
609810 Canis lupus familiaris
767898 Bos taurus
12193 Mus musculus
298765 Rattus norvegicus
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