anti-Nucleoporin 98kDa (NUP98) Antikörper

Bezeichnung:
anti-Nucleoporin 98kDa Antikörper (NUP98)
Auf www.antikoerper-online.de finden Sie aktuell 66 Nucleoporin 98kDa (NUP98) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nucleoporin 98kDa Kits (18) und Nucleoporin 98kDa Proteine (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 101 Nucleoporin 98kDa Produkte verfügbar.
Synonyme:
4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, NUP96, NUP98, Nup 98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968
Alle Antikörper anzeigen Gen GeneID UniProt
NUP98 269966  
NUP98 81738 P49793
NUP98 4928 P52948

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Meistgesuchte Reaktivitäten zu anti-Nucleoporin 98kDa (NUP98) Antikörper

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Am meisten referenzierte anti-Nucleoporin 98kDa Antikörper

  1. Human Monoclonal NUP98 Primary Antibody für DB, ICC - ABIN2452066 : Fukuhara, Ozaki, Shikata, Katahira, Yoneda, Ogino, Tachibana: Specific monoclonal antibody against the nuclear pore complex protein, nup98. in Hybridoma (2005) 2005 (PubMed)
    Zeige alle 2 Referenzen für 2452066

  2. Human Monoclonal NUP98 Primary Antibody für IF, WB - ABIN2452065 : Iwamoto, Asakawa, Hiraoka, Haraguchi: Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms. in Genes to cells : devoted to molecular & cellular mechanisms 2010 (PubMed)
    Zeige alle 2 Referenzen für 2452065

  3. Human Monoclonal NUP98 Primary Antibody für IF, WB - ABIN2452064 : Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans. in Monoclonal antibodies in immunodiagnosis and immunotherapy 2013 (PubMed)
    Zeige alle 2 Referenzen für 2452064

  4. Human Polyclonal NUP98 Primary Antibody für IP, WB - ABIN408604 : Franks, Benner, Narvaiza, Marchetto, Young, Malik, Gage, Hetzer: Evolution of a transcriptional regulator from a transmembrane nucleoporin. in Genes & development 2016 (PubMed)

  5. Cow (Bovine) Polyclonal NUP98 Primary Antibody für IF, WB - ABIN2781008 : Pan, Zhu, Gu, Cai, Bai, Yun, Zhu, Chen, Weng, Chen, Xue, Chen: A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. in Oncogene 2008 (PubMed)

Weitere Antikörper gegen Nucleoporin 98kDa Interaktionspartner

Fruit Fly (Drosophila melanogaster) Nucleoporin 98kDa (NUP98) Interaktionspartner

  1. Nup98 provides a scaffold for poised genes and mediates Induced enhancer-promoter contacts in genetic transcription.

  2. Nup98 associates and colocalizes with the MBD (zeige DPEP1 Antikörper)-R2/NSL and Trx (zeige GSR Antikörper) complexes. Nup98 regulates transcription of Trx (zeige GSR Antikörper) targets, the Hox (zeige MSH2 Antikörper) genes.

  3. Nup98, a virus-induced gene, was antiviral against a panel of viruses.

  4. Study analyzed genomic interactions of full-length nucleoporins Nup98, Nup50 (zeige NUP50 Antikörper), and Nup62 and found that they predominantly interacted with active genes inside the nucleoplasm, particularly those involved in developmental regulation and the cell cycle.

  5. Nup88 (zeige NUP88 Antikörper) localizes to silent loci, Sec13 (zeige SEC13 Antikörper), Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction.

Mouse (Murine) Nucleoporin 98kDa (NUP98) Interaktionspartner

  1. We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 (zeige SETBP1 Antikörper) negatively regulate the XPO1 (zeige XPO1 Antikörper)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.

  2. The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (zeige HOXD13 Antikörper) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR (zeige EIF2AK2 Antikörper) transgene.

  3. Nup50 (zeige NUP50 Antikörper) dynamics are independent of importin alpha, Nup153 (zeige NUP153 Antikörper), and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.

  4. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b (zeige CDKN2B Antikörper)) collaborates with oncogene (zeige RAB1A Antikörper) fusion protein Nup98-HoxD13 (zeige HOXD13 Antikörper) transgene in the development of predominantly myeloid neoplasms.

  5. Homeobox (zeige PRRX1 Antikörper) partners create more potent NUP98 fusion oncogenes than do non-homeobox (zeige PRRX1 Antikörper) partners.

  6. findings show that expression of NUP98-HOXD13 (zeige HOXD13 Antikörper) impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia

  7. Mice expressing both the FLT3 (zeige FLT3 Antikörper)/ITD and Nup98-HoxD13 (zeige HOXD13 Antikörper) (NHD13) fusion gene developed acute myeloid leukemia (zeige BCL11A Antikörper) with 100% penetrance

  8. Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox (zeige MSH2 Antikörper) fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells.

  9. These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1 (zeige XPO1 Antikörper)-mediated nuclear export in conjunction with RanBP3 (zeige RANBP3 Antikörper).

  10. A mouse model of CML blast crisis induced by cooperation between BCR/ABL (zeige ABL1 Antikörper) and NUP98/HOXA9 (zeige HOXA9 Antikörper)

Zebrafish Nucleoporin 98kDa (NUP98) Interaktionspartner

  1. data show that a novel nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98.

Human Nucleoporin 98kDa (NUP98) Interaktionspartner

  1. DYNLT1 (zeige DYNLT1 Antikörper) interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin (zeige AGFG2 Antikörper) fusion, NUP98-HOXA9 (zeige HOXA9 Antikörper)

  2. the mutation order in the NUP98-rearranged pediatric AML (zeige RUNX1 Antikörper) begins with the NUP98 rearrangement leading to epigenetic dysregulations then followed by mutations of critical hematopoietic transcription factors and finally, activation of the FLT3 (zeige FLT3 Antikörper) signaling pathway.

  3. These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 oncoproteins to interact with APC (zeige APC Antikörper)/C(Cdc20 (zeige CDC20 Antikörper)) and to interfere with its function.

  4. Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells.

  5. NUP98-HOXA9 (zeige HOXA9 Antikörper) ability to induce blood cell expansion is evolutionarily conserved.

  6. The study demonstrated the association of NUP98-IQCG with CRM1 (zeige XPO1 Antikörper), and found that NUP98-IQCG expression inhibits the CRM1 (zeige XPO1 Antikörper)-mediated nuclear export of p65 (zeige GORASP1 Antikörper) and enhances the transcriptional activity of nuclear factor-kappaB. Moreover, IQCG could be entrapped in the nucleus by NUP98-IQCG, and the fusion protein interacts with calmodulin (zeige CALM1 Antikörper) via the IQ motif in a calcium-independent manner.

  7. The results indicate that highly selective targeting of Nup98-fusion proteins to Hox (zeige MSH2 Antikörper) cluster regions via prebound Crm1 (zeige XPO1 Antikörper) induces the formation of higher order chromatin structures that causes aberrant Hox (zeige MSH2 Antikörper) gene regulation.

  8. Despite the difference in localization, all tested Nup98 chimera provoked morphological alterations in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2alpha.

  9. NUP98-HOXA9 (zeige HOXA9 Antikörper) expression induces myeloid disease.

  10. Overall, these results demonstrate a novel role for FOXK1 (zeige FOXK2 Antikörper) in regulating the expression of antiviral genes via Nup98, from insects to humans.

Xenopus laevis Nucleoporin 98kDa (NUP98) Interaktionspartner

  1. These data support a model in which Nup98 interacts with microtubules and antagonizes MCAK (zeige KIF2C Antikörper) activity, thus promoting bipolar spindle assembly.

Nucleoporin 98kDa (NUP98) Antigen-Profil

Beschreibung des Gens

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.

Alternative names and synonyms associated with Nucleoporin 98kDa (NUP98)

  • Nucleoporin 98-96 (Nup98-96) Antikörper
  • nucleoporin 98kDa (Nup98) Antikörper
  • nucleoporin 98kDa (NUP98) Antikörper
  • nucleoporin 98 (Nup98) Antikörper
  • nucleoporin 98 (nup98) Antikörper
  • Nup98 protein (nup98) Antikörper
  • 4732457F17 Antikörper
  • ADIR2 Antikörper
  • AI849286 Antikörper
  • CG10198 Antikörper
  • CG10201 Antikörper
  • Dmel\\CG10198 Antikörper
  • GB12688 Antikörper
  • im:7151238 Antikörper
  • l(3)95BCd Antikörper
  • Nup-98 Antikörper
  • Nup 96 Antikörper
  • NUP96 Antikörper
  • NUP98 Antikörper
  • Nup 98 Antikörper
  • nup98-96 Antikörper
  • Nup98-Nup96 Antikörper
  • Nup98/96 Antikörper
  • nup145 Antikörper
  • NUP196 Antikörper
  • zgc:63593 Antikörper
  • zgc:113968 Antikörper

Bezeichner auf Proteinebene für NUP98

CG10198-PA , CG10198-PC , CG10198-PD , Nup98 , Nup98-96-PA , Nup98-96-PC , Nup98-96-PD , nucleoporin 98 , nucleoporin 98-96 , nucleoporin98-96 , nucleoporin 98kD , nucleoporin 98kDa , nuclear pore complex protein Nup98-Nup96-like , nuclear pore complex protein Nup98-Nup96 , 98 kDa nucleoporin , nuclear pore complex protein Nup98 , nucleoporin Nup98 , GLFG-repeat containing nucleoporin , Nup98-Nup96

GENE ID SPEZIES
42816 Drosophila melanogaster
408335 Apis mellifera
450971 Pan troglodytes
587580 Strongylocentrotus purpuratus
100016427 Monodelphis domestica
100052986 Equus caballus
100090367 Ornithorhynchus anatinus
100414799 Callithrix jacchus
100475098 Ailuropoda melanoleuca
100522560 Sus scrofa
269966 Mus musculus
81738 Rattus norvegicus
777756 Danio rerio
430616 Gallus gallus
4928 Homo sapiens
476822 Canis lupus familiaris
540004 Bos taurus
100343626 Oryctolagus cuniculus
446233 Xenopus laevis
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