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Human LRP1 ELISA Kit für Sandwich ELISA - ABIN414517
de Gonzalo-Calvo, Cenarro, Martínez-Bujidos, Badimon, Bayes-Genis, Ordonez-Llanos, Civeira, Llorente-Cortés: Circulating soluble low-density lipoprotein receptor-related protein 1 (sLRP1) concentration is associated with hypercholesterolemia: A new potential biomarker for atherosclerosis. in International journal of cardiology 2015
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Human LRP1 ELISA Kit für Sandwich ELISA - ABIN457030
Kepa, Horvath, Reitter-Pfoertner, Schemper, Quehenberger, Grundbichler, Heistinger, Neumeister, Mannhalter, Pabinger: Parameters influencing FVIII pharmacokinetics in patients with severe and moderate haemophilia A. in Haemophilia : the official journal of the World Federation of Hemophilia 2015
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Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (zeige CXCL12 ELISA Kits) antagonize shedding through a TSP-1 (zeige THBS1 ELISA Kits)-dependent pathway and ligation of CD28 (zeige CD28 ELISA Kits) antagonizes shedding independent of TSP-1 (zeige THBS1 ELISA Kits).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 (zeige TIMP3 ELISA Kits) as an underlying mechanism.
findings revealed a pH-dependent release of the ligand associated with a conformational change of the receptor. In summary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of this important receptor and provides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated system.
although fVIII (zeige F8 ELISA Kits) bound avidly to soluble forms of clusters II and IV from LRP1, only soluble cluster IV competed with the binding of fVIII (zeige F8 ELISA Kits) to full-length LRP1, revealing that cluster IV represents the major fVIII (zeige F8 ELISA Kits) binding site in LRP1.
LRP1 protein expression in human abdominal aortic aneurysm tissues may be down-regulated by miR (zeige MLXIP ELISA Kits)-205 through translational inhibition, resulting in a reduced clearance of pericellular MMP-9 (zeige MMP9 ELISA Kits), promoting aneurysm formation.
data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
results indicate that genetic variations in LRP1 and ULK4 contribute to risk for presenting with an acute aortic dissection
Considering that LRP-1, by mediating the clearance of matrix metalloproteinases, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activity of MMPs shown in cancers.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (zeige PRKAA1 ELISA Kits) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (zeige MAPK8 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (zeige APOC3 ELISA Kits) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (zeige LDLR ELISA Kits)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 ELISA Kits) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (zeige BMPER ELISA Kits)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
report that LRP1 expression is rapidly lost as oligodendrocyte progenitor cells differentiate, and is absent from all oligodendrocytes, including newborn oligodendrocytes
Results show evidence of low-density lipoprotein receptor-related protein 1 ( (LRP1) expression and activity modulation by Intravenous immunoglobulin (IVIg), and support the role of LRP1 as a partner of IVIg in the execution of its neuroprotective effects.
LRP1 deficiency in mature adipocytes promotes diet-induced inflammation and atherosclerosis.
TNF-alpha (zeige TNF ELISA Kits) blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1.
these results documented that LRP1 deficiency in hepatocytes promotes lipid accumulation and lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in cell death. Hence, LRP1 dysfunction may be a major risk factor in fatty liver disease progression.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1