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Using double labeling with Iba-1 and cd68 (zeige CD68 Proteine) could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity.
The results of our study suggest that the AIF1 gene polymorphisms have no influence on long-term kidney allograft function.
Data showed that AIF-1 promoted the proliferation of HepG2 cells by accelerating the activation of IGF-1R (zeige IGF1R Proteine) and its downstream signaling pathway, which confirms that AIF-1 plays a crucial role in the development of hepatocellular carcinoma cells.
AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin (zeige CTNNB1 Proteine) in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
AIF-1, which induced chemokines and enhanced chemotaxis of monocytes, may represent a molecular target for the therapy of immune-inflammatory disorders
The results of this study suggest a lack of association between AIF-1 gene polymorphisms and response to sulphasalazine treatment in rheumatoid arthritis.
The results of this study suggest that the patients with the rs2259571 CC AIF1 genotype have a poorer response to therapy with Methotrexate.
We are unable to find statistically significant association between COX-2 and AIF-1 gene polymorphisms and allograft survival.
The overexpressed AIF-1, the novel inflammatory polypeptide derived from macrophage lineages, is closely associated with atherogenesis via affecting the blood composition and promoting macrophage uptake and foam cell formation.
AIF-1 can protect rheumatoid arthritis fibroblast-like synoviocytes from apoptosis induced by NO by upregulating the expression of p-Akt (zeige AKT1 Proteine) and p-BAD.
AIF-1 plays an important role in the mechanism underlying acute lung injury.
These results imply daintain/AIF-1 triggers type 1 diabetes probably via arousing immune cells activation and induction of NO production in pancreas of NOD mice.
AIF-1 was overexpressed in the liver of BALB/c mice infected with S. japonicum, and the interaction between AIF-1 and TNF-alpha (zeige TNF Proteine) or other cytokines played an important role in the pathogenesis and progression of hepatic schistosomiasis.
Data suggest a strong association between AIF-1 expression, NF-kappaB (zeige NFKB1 Proteine) activation, and development of experimental atherosclerosis.
AIF-1 can induce IL-6 (zeige IL6 Proteine) secretion on mononuclear cells and fibroblast chemotaxis. AIF-1 may accordingly provide an attractive new target for antifibrotic therapy in SSc (zeige CYP11A1 Proteine) as well as Scl (zeige TAL1 Proteine) GVHD.
interferon gamma (zeige IFNG Proteine) inducable and macrophage restricted expression requires Pu.1
This study demonstrated for the first time that allograft inflammatory factor-1(AIF-1) was expressed in uterus, and a correlation between AIF-1 production and fetal resorption in mice.
These data indicate that AIF-1 mediates atherogenesis-initiated signaling and activation of macrophages.
The molecular conformational change induced by Ca(2 (zeige CA2 Proteine)+)-binding of Iba1 is different from that found in the classical EF-hand proteins, which demonstrates that Iba1 has an unique molecular switching mechanism dependent on Ca(2 (zeige CA2 Proteine)+)-binding.
AIF-1/Iba1 can be regarded a "pan-macrophage marker" because, except for alveolar macrophages, all subpopulations of macrophages examined express AIF-1/Iba1.
apoptosis-inducing factor(AIF (zeige AIFM1 Proteine)) was expressed in luminal alveolar cells and in concert with a change in bax (zeige BAX Proteine) protein to bcl-2 (zeige BCL2 Proteine) protein ratio might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses(AIF (zeige AIFM1 Proteine))
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene.
allograft inflammatory factor 1
, Allograft inflammatory factor 1
, allograft inflammatory factor-1 splice variant Hara-1
, interferon gamma responsive transcript
, ionized calcium-binding adapter molecule 1
, protein G1
, balloon angioplasty responsive transcript
, balloon angioplasty-responsive transcript 1
, ionized calcium binding adapter molecule 1
, microglia response factor
, protein BART-1
, testis specific
, anti-inflammatory factor 1