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Human WDR1 Protein expressed in Escherichia coli (E. coli) - ABIN1047936
Adler, Winnicki, Gong, Lomax: A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. in Genomics 1999
Identify positive correlations between WDR1 and CLNK (zeige CLNK Proteine) gene polymorphisms in Chinese-Tibetan gout populations.
Demonstrate a previously unanticipated role of Aip1 (zeige BIRC3 Proteine) in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis.
When maternal environmental tobacco smoke was considered, fifteen of 135 single nucleotide polymorphism (SNPs) mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance.
Data suggest that anti-WD repeat domain 1 (WDR1) antibody could be applied for serological screening of papillary thyroid carcinoma (PTC (zeige F9 Proteine)) and undifferentiated thyroid carcinoma (UTC), and could be an efficient and inexpensive biomarker.
WD repeat-containing protein 1 was confirmed as being significantly overexpressed in interstitial fluid from ovarian carcinomas compared to healthy ovarian tissue.
Studies suggest that vascular endothelial growth factor may be responsible for upregulated P-glycoprotein expression.
The QKI (zeige QKI Proteine) RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1 (zeige BIRC3 Proteine).
Studies indicate that CUL4 uses a large beta-propeller protein, DDB1 (zeige DDB1 Proteine), as a linker to interact with a subset of WD40 (zeige DCAF12L2 Proteine) proteins.
AIP1/WDR1 could abort the severing/disassembly activity somewhat still carried out due to phosphorylated ADF/cofilin (zeige CFL1 Proteine)
Data indicates that Aip1 (zeige BIRC3 Proteine) plays an important role in directional cell migration by restricting the stimulus-induced membrane protrusion to one direction via promoting cofilin (zeige CFL1 Proteine) activity.
WDR1 interacts with Lim domain kinase 1 (LIMK1 (zeige LIMK1 Proteine)), a well known phosphorylation kinase of Cofilin (zeige CFL1 Proteine).
Wdr1 and cofilin (zeige CFL1 Proteine)/destrin (zeige DSTN Proteine)-mediated actomyosin remodelling are essential for generating or maintaining cortical tension within the developing epidermal sheet and driving the cell shape and planar orientation changes.
Wdr1-regulated actin dynamics play essential roles in heart function in mice. F-actin accumulations caused by Wdr1 deletion result in disruption of sarcomeric structure.
The QKI (zeige QKI Proteine) RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1.
studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
, WD repeat-containing protein 1
, actin-interacting protein 1
, WD40 repeat protein 1
, WD repeat protein 1