anti-Maus SCO1 Cytochrome C Oxidase Assembly Protein Antikörper für ELISA

Recommended SCO1 Cytochrome C Oxidase Assembly Protein Antibody (geliefert von: Anmelden zum Anzeigen )

SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) Antikörper
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • SCOD1
  • RGD1559538
  • kit oncogene
  • SCO cytochrome oxidase deficient homolog 1 (yeast)
  • SCO1 cytochrome c oxidase assembly protein
  • Kit
  • SCO1
  • Sco1
Human, Maus, Ratte (Rattus)
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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Produktnummer ABIN1003126
$ 466.62
Zzgl. Versandkosten $45.00
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Antigen SCO1 Cytochrome C Oxidase Assembly Protein (SCO1) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(32), (14), (14), (4), (3), (3), (3), (3), (2), (1), (1)
Wirt Kaninchen
(28), (4)
Applikation Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(29), (12), (9), (9), (7), (3), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen


Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN1004448.
Reinigung Affinity chromatography purified via peptide column.
Immunogen SCO1 antibody was raised against a 14 amino acid peptide from near the center of human SCO1.
Isotyp IgG


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Andere Bezeichnung SCO1 (SCO1 Antibody Abstract)
Hintergrund Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.
Forschungsgebiet Signaling, Metabolism, Organelles
Pathways Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity


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Applikationshinweise SCO1 antibody can be used for detection of SCO1 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Beschränkungen Nur für Forschungszwecke einsetzbar


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Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months


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Produkt verwendet in:

Banci, Bertini, Ciofi-Baffoni, Leontari, Martinelli, Palumaa, Sillard, Wang: "Human Sco1 functional studies and pathological implications of the P174L mutant." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 1, pp. 15-20, 2007

Horng, Leary, Cobine, Young, George, Shoubridge, Winge: "Human Sco1 and Sco2 function as copper-binding proteins." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 34113-22, 2005

Valnot, Osmond, Gigarel, Mehaye, Amiel, Cormier-Daire, Munnich, Bonnefont, Rustin, Rötig: "Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy." in: American journal of human genetics, Vol. 67, Issue 5, pp. 1104-9, 2000

Glerum, Shtanko, Tzagoloff: "SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae." in: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20531-5, 1996