anti-Hexosaminidase A (HEXA) Antikörper

Auf finden Sie aktuell 136 Hexosaminidase A (HEXA) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Hexosaminidase A Kits (22) und Hexosaminidase A Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 178 Hexosaminidase A Produkte verfügbar.
DKFZp459O0432, fc04h11, Hex-1, HEXA, si:dkey-35i22.2, TSD, wu:fc04h11, wu:fv09f06
Alle Antikörper anzeigen Gen GeneID UniProt
HEXA 15211 P29416
HEXA 300757 Q641X3
HEXA 3073 P06865

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Weitere Antikörper gegen Hexosaminidase A Interaktionspartner

Mouse (Murine) Hexosaminidase A (HEXA) Interaktionspartner

  1. Neu4 (zeige NEU4 Antikörper) is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.

Human Hexosaminidase A (HEXA) Interaktionspartner

  1. The alpha mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type alpha. E482K is more severely misfolded than G269S, as observed by its aggregation and inability to associate with the HexA beta chain. Importantly, both mutants are retrotranslocated from the endoplasmic reticulum to the cytosol and are degraded by the ...

  2. reports a new missense mutation in the HEXA gene in two German siblings with late-onset Tay-Sachs disease and prominent psychiatric symptoms

  3. The silencing of the HEXA gene had a stronger immune inhibitory effect, thereby indicating a major involvement of beta-N-acetyl-hexosaminidase A isoenzyme within this mechanism.

  4. Human prostate cancer cells are characterised by a significant decrease in HexA activity.

  5. DNA reveals novel mutations in Iranian subjects causing Tay-Sachs disease in the alpha and beta subunits of HexA.

  6. GM2 (zeige CYB5D2 Antikörper) gangliosidosis is caused by the gene mutation. (review)

  7. identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB (zeige HEXB Antikörper) gene, and attempted to correlate these mutations with the clinical presentation of the patients

  8. HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.

  9. Beta-hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells.

  10. We report the first Jordanian Arab Tay-Sachs disease patient diagnosed by deficient beta-hexosaminidase A activity, mutation analysis revealed homozygosity for a nonsense HEXA mutation, c.78G>A (p.W26X)

Cow (Bovine) Hexosaminidase A (HEXA) Interaktionspartner

  1. SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy.

Hexosaminidase A (HEXA) Antigen-Profil

Beschreibung des Gens

This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Alternative names and synonyms associated with Hexosaminidase A (HEXA)

  • hexosaminidase A (alpha polypeptide) (HEXA) Antikörper
  • hexosaminidase A (alpha polypeptide) (hexa) Antikörper
  • hexosaminidase A (LOC100228061) Antikörper
  • hexosaminidase A (Hexa) Antikörper
  • DKFZp459O0432 Antikörper
  • fc04h11 Antikörper
  • Hex-1 Antikörper
  • HEXA Antikörper
  • si:dkey-35i22.2 Antikörper
  • TSD Antikörper
  • wu:fc04h11 Antikörper
  • wu:fv09f06 Antikörper

Bezeichner auf Proteinebene für HEXA

beta-hexosaminidase subunit alpha , beta-hexosaminidase subunit beta , beta-hexosaminidase alpha chain , hexosaminidase A (alpha polypeptide) , beta-hexosaminidase alpha-subunit , hexosaminidase A , Beta-hexosaminidase alpha chain , N-acetyl-beta-glucosaminidase subunit alpha , beta-N-acetylhexosaminidase subunit alpha , hexosaminidase subunit A , Hexose aminidase A (alpha polypeptide) , hexosaminidase A alpha

100145856 Ovis aries
100063584 Equus caballus
323613 Danio rerio
415320 Gallus gallus
748732 Pan troglodytes
100008950 Oryctolagus cuniculus
100302663 Pongo abelii
100195429 Salmo salar
100228061 Taeniopygia guttata
15211 Mus musculus
300757 Rattus norvegicus
3073 Homo sapiens
504468 Bos taurus
487633 Canis lupus familiaris
100142664 Sus scrofa
100438794 Pongo abelii
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