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UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.
ablation of Glut1 attenuated apoptosis and increased drug resistance via upregulation of p-Akt (zeige AKT1 Proteine)/p-GSK-3beta (Ser9)/beta-catenin (zeige CTNNB1 Proteine)/survivin (zeige BIRC5 Proteine).
Data show that SALL4 (zeige SALL4 Proteine) promotes the expression of Glut1 and open chromatin through a HP1alpha (zeige CBX5 Proteine)-dependent mechanism.
Results show that PPARalpha (zeige PPARA Proteine) directly targeted the consensus PPRE motif of Glut1 promoter region resulting in Glut1 transcription repression leding to decreased influx of glucose in cancer cells.
Strong GLUT1 staining was inversely associated with circulating levels of fasting glucose in high grade serous ovarian cancer.
Results show that resistin (zeige RETN Proteine) down-regulates the transcription of GLUT1 by suppressing the expression of PPARG (zeige PPARG Proteine), thus causing impaired glucose transportation in endothelial cell layers.
Metabolically active CD4 (zeige CD4 Proteine)+ T cells expressing Glut1 and OX40 (zeige TNFRSF4 Proteine) preferentially harbor HIV during in vitro infection.
we found that PPARdelta (zeige PPARD Proteine) directly regulated neutral amino acid transporter (zeige SLC6A19 Proteine) SLC1 (zeige MCHR1 Proteine)-A5 (solute carrier family 1 member 5 (zeige SLC1A5 Proteine)) and glucose transporter-1 (Glut1) gene transcription, leading to uptake of glucose and amino acid, activation of mTOR (zeige FRAP1 Proteine) signaling, and tumor progression. In contrast, silence of PPARdelta (zeige PPARD Proteine) or its antagonist inhibited this event.
SLC2A1/GLUT1 is expressed late in the adenoma-carcinoma sequence during carcinogenesis in intraductal papillary mucinous neoplasms of the pancreas.
Paraoxonase 2 (zeige PON2 Proteine) facilitates pancreatic ductal cancer growth and metastasis by stimulating GLUT1-mediated glucose transport.
GLUT1 may play an important role in Prostate Cancer progression via mediating glycolysis and proliferation. There is potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in Prostate Cancer.
ARAP2 knockdown did not affect fatty acid uptake but reduced basal glucose uptake, total levels of the glucose transporter GLUT1, and GLUT1 levels in the plasma membrane and the lipid micro-domain fraction.
TBC1D5 (zeige TBC1D5 Proteine) shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking.
inhibition of GLUT1 activity and/or expression is shown to impair TGF-beta (zeige TGFB1 Proteine)-driven fibrogenic processes, including cell proliferation and production of profibrotic mediators
B cell leukemia-induced inhibition of T cell Akt (zeige AKT1 Proteine)/mTORC1 signaling and glucose metabolism drives T cell dysfunction; metabolic defects included reduced Akt (zeige AKT1 Proteine)/mammalian target of rapamycin (zeige FRAP1 Proteine) complex 1 (mTORC1) signaling, decreased expression of the glucose transporter Glut1 and hexokinase 2 (zeige HK2 Proteine), and reduced glucose uptake
This study demonstrates a strict requirement for GLUT1 in the early stages of mammary tumorigenesis in vitro and in vivo.
GLUT1-dependent glycolysis regulates fibrogenesis in aged lung.
Data (including data from studies using transgenic mice) suggest that Glut1 (glucose transporter type 1) is a critical downstream target of Hif1a (hypoxia-inducible factor 1 (zeige HIF1A Proteine), alpha subunit (zeige POLG Proteine)) mediating hyperglycemia-induced extracellular matrix accumulation in kidney via regulation of Nox4 (zeige NOX4 Proteine) (NADPH oxidase (zeige NOX1 Proteine) type 4) expression in nephropathy due to diabetes type 1.
CRISPR/Cas9-mediated disruption of the Hdac2 gene increased Slc2a1 expression, suggesting that it is one of the responsible histone deacetylases (HDACs). These results confirm that b-OHB is a HDAC inhibitor and show that b-OHB plays an important role in fasting-induced epigenetic activation of a glucose transporter gene in the brain.
Taken together, the data suggest that curcumin binds directly to GLUT1 at a site that overlaps with the cytochalasin B binding site and thereby inhibits glucose transport.
Glut-1 expression globally depended on histological subtypes and the staining patterns (diffuse or zonal) were different between thymic carcinomas and type B3 thymomas
Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness.
Glucose transporter 1 transcript levels were higher in the right ventricle than the left ventricle.
pGlcT, together with MEX1, contributes significantly to the export of starch degradation products from chloroplasts in A. thaliana leaves and and that this starch-mediated pathway for photoassimilate export via pGlcT and MEX1 is essential for the growth and development of A. thaliana. [pGlcT]
Low GLUT1 and GLUT3 (zeige SLC2A3 Proteine) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 (zeige SLC2A4 Proteine) mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (zeige INS Proteine) responsive.
the different conformations of the GLUT-1 transporter in luminal (blood facing) and abluminal (brain facing) membranes of bovine cerebral endothelial cells arise from differential phosphorylation of GLUT-1
Significant increases in GLUT1 gene expression were observed during early lactation.
Hyperthermia-induced Hsp90 (zeige HSP90 Proteine).eNOS (zeige NOS3 Proteine) preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD (zeige G6PD Proteine) activity.
distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry
Expression of GLUT1 was evaluated in LLC-PK1 cells grown on porous membranes for the development of an artificial kidney.
results suggest that glucose is transported to the axonal cleft intracytoplasmically and delivered to the cleft by GLUT1 transporters
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia.
, glucose transporter type 1, erythrocyte/brain
, hepG2 glucose transporter
, human T-cell leukemia virus (I and II) receptor
, solute carrier family 2, facilitated glucose transporter member 1
, solute carrier family 2, member 1
, Solute carrier family 2 a 1 (facilitated glucose transporter) brain
, Solute carrier family 2, facilitated glucose transporter member 1
, glucose transporter
, glucose transporter 1
, lethal (3) S007412
, solute carrier family 2 (facilitated glucose transporter), member 1
, solute carrier family 2 member 1
, excitatory amino acid transporter 1
, glial glutamate transporter
, glutamate transporter
, glutamate/aspartate transporter
, sodium-dependent glutamate/aspartate transporter 1
, solute carrier family 1, member 3
, glucose transporter protein
, glucose transporter type 1
, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog
, glucose transport protein