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The level of WASF2 in gastric cancer tissues was negatively correlated with miR (zeige MLXIP Proteine)-146a expression and had inverse clinicopathologic features. The newly identified miR (zeige MLXIP Proteine)-146a/WASF2 axis may provide a novel therapeutic target for gastric cancer.
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (zeige VPS72 Proteine) in U251 human glioma cells.
SH3BP1 (zeige SH3BP1 Proteine) promoted VEGF (zeige VEGFA Proteine) secretion via Rac1-WAVE2 signaling, so as to exert an augmentation on cell invasion and microvessel formation.
the MCP1 (zeige CCL2 Proteine)-induced cortactin (zeige CTTN Proteine) phosphorylation is dependent on PLCb3 (zeige PLCB3 Proteine)-mediated PKC (zeige PRRT2 Proteine) activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin (zeige CTTN Proteine) interaction with WAVE2
WASp and WAVE2 differ in their dynamics and their associated proteins
these results suggest that Arp2 (zeige ACTR2 Proteine)/3 and the upstream regulator, WAVE2, are essential co-factors hijacked by HIV for intracellular migration, and may serve as novel targets to prevent HIV transmission.
WAVE2 is down-regulated in gastric cancer
Cortactin (zeige CTTN Proteine) has a role as a scaffold for Arp2 (zeige ACTR2 Proteine)/3 and WAVE2 at the epithelial zonula adherens
data reveal a critical role for WAVE2 complex in regulation of cellular signaling and epithelial morphogenesis
Identification of an onco-suppressive role of miR (zeige MLXIP Proteine)-146a in gastric cancer cells by its reduction of WASF2 expression.
Rho family GTPases use the I-BAR proteins, IRSp53 (zeige BAIAP2 Proteine) (also known as BAIAP2 (zeige BAIAP2 Proteine)), IRTKS (zeige BAIAP2L1 Proteine) and Pinkbar (zeige BAIAP2L2 Proteine), as a central mechanism to modulate cell morphology.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
The expression of NESH/Abi-3 (zeige ABI3 Proteine) caused degradation of endogenous Abi-1 (zeige ABI1 Proteine), which led to the formation of a NESH/Abi-3 (zeige ABI3 Proteine)-based WAVE2 complex.
This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
Results of the present study show that the nucleation-promoting factors JMY (zeige JMY Proteine) and WAVE2 are critical for cytokinesis during development of mouse embryos.
These results identify Wasf2 as a novel target of intermittent PTH administration via the Wnt and phosphoinositide-dependent protein kinase signaling pathways.
The protein and messenger RNA levels of WAVE2 were decreased in aged oocytes, but the levels were normal in caffeine-treated aged oocytes.
mDia1 and WAVE2 are important Src (zeige SRC Proteine) homology 3 domain partners of IRSp53 (zeige BAIAP2 Proteine) in forming filopodia.
WAVE2 regulates oocyte polarization by regulating meiotic spindle, peripheral positioning, probably via an actin-mediated pathway, and is involved in polar body emission during mouse oocyte meiotic maturation.
sential role for Abi1 (zeige ABI1 Proteine) in embryonic survival and WAVE2 complex integrity
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.
WAS protein family, member 2
, wiskott-Aldrich syndrome protein family member 2
, WASP family Verprolin-homologous protein 2
, WASP family protein member 2
, WASP family protein member 4
, protein WAVE-2
, putative Wiskott-Aldrich syndrome protein family member 4
, suppressor of cyclic-AMP receptor (WASP-family)
, verprolin homology domain-containing protein 2