VEGFC Proteine (VEGFC)

Bezeichnung:
Vascular Endothelial Growth Factor C Proteine (VEGFC)
Auf www.antikoerper-online.de finden Sie aktuell 84 Vascular Endothelial Growth Factor C (VEGFC) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VEGFC Antikörper (301) und VEGFC Kits (66) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 458 VEGFC Produkte verfügbar.
Synonyme:
AW228853, Flt4-L, VEGF-C, VEGFC, VRP, xvegf-c
alle Proteine anzeigen Gen GeneID UniProt
VEGFC 7424 P49767
VEGFC 22341 P97953
VEGFC 114111 O35757

Weitere Synonyme anzeigen

VEGFC Proteine (VEGFC) nach Spezies

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Am meisten referenzierte VEGFC Proteine

  1. Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN413872 : Werchau, Toberer, Enk, Dammann, Helmbold: Merkel cell carcinoma induces lymphatic microvessel formation. in Journal of the American Academy of Dermatology 2011 (PubMed)
    Zeige alle 6 Referenzen für 413872

  2. Human VEGFC Protein expressed in CHO Cells - ABIN2666942 : Cai, Ma, Gu, Zu, Qu, Zheng: Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer. in Diagnostic pathology 2012 (PubMed)
    Zeige alle 6 Referenzen für 2666942

  3. Mouse (Murine) VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN1047898 : Fitz, Morris, Towler, Long, Burgess, Greco, Wang, Gassaway, Nickbarg, Kovacic, Ciarletta, Giannotti, Finnerty, Zollner, Beier, Leak, Turner, Wood: Characterization of murine Flt4 ligand/VEGF-C. in Oncogene 1997 (PubMed)
    Zeige alle 3 Referenzen für 1047898

  4. Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN1047897 : Lee, Gray, Yuan, Luoh, Avraham, Wood: Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Zeige alle 2 Referenzen für 1047897

  5. Rat (Rattus) VEGFC Protein expressed in Human Cells - ABIN2009156 : Mandriota, Pepper: [Lymphangiogenesis and biological activity ov vascular endothelial growth factor-C]. in Journal de la Société de biologie 1999 (PubMed)

  6. Human VEGFC Protein expressed in Wheat germ - ABIN1324984 : Singh, Tiem, Watkins, Cho, Wang, Olsen, Uehara, Mamalis, Luo, Oakey, Ambati: Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity. in Blood 2013 (PubMed)

Weitere Proteine zu VEGFC Interaktionspartnern

Zebrafish Vascular Endothelial Growth Factor C (VEGFC) Interaktionspartner

  1. Vegfc acts through ERK (zeige MAPK1 Proteine) to induce sprouting and differentiation of trunk lymphatic progenitors.

  2. data not only reveal a non-canonical function of Mt2 (zeige MT2 Proteine) in angiogenesis, but also propose Mt2 (zeige MT2 Proteine) as a novel regulator of vegfc expression.

  3. Vegfc signaling increases mafba (zeige MAFB Proteine) expression to control downstream transcription

  4. Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.

  5. In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (zeige CCBE1 Proteine), and Vegfc-driven sprouting is enhanced by local Ccbe1 (zeige CCBE1 Proteine) overexpression. Moreover, Vegfc- and Vegfr3 (zeige FLT4 Proteine)-dependent Erk (zeige MAPK1 Proteine) signaling is impaired in the absence of Ccbe1 (zeige CCBE1 Proteine).

  6. Vegfc has an essential role in lymphangiogenesis [review]

  7. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (zeige FLT4 Proteine) signaling in zebrafish.

  8. Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.

  9. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  10. Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.

Pig (Porcine) Vascular Endothelial Growth Factor C (VEGFC) Interaktionspartner

  1. VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema

  2. Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.

  3. No difference in bioactivity was detected between porcine relaxin-1 (zeige RLN1 Proteine) and recombinant human relaxin-2 (zeige RLN1 Proteine) in either mice or rats.

  4. During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer

Human Vascular Endothelial Growth Factor C (VEGFC) Interaktionspartner

  1. Data show that VEGF-C, VEGF-D (zeige Figf Proteine), and VEGFR-3 (zeige FLT4 Proteine) were expressed in a substantial percentage of breast carcinomas.

  2. By treating LECs with VEGF (zeige VEGFA Proteine)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (zeige JUN Proteine)' transcription factors that showed a rapid transient upregulation VEGFR-3 (zeige FLT4 Proteine) stimulation. these results reveal an important and unanticipated role of HOXD10 (zeige HOXD10 Proteine) in the regulation of VEGFR-3 (zeige FLT4 Proteine) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.

  3. In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.

  4. High VEGFC expression is associated with angiogenesis and lymphangiogenesis.

  5. Adiponectin (zeige ADIPOQ Proteine) promoted VEGF-C expression and secretion in human chondrosarcoma cells.

  6. HuR (zeige ELAVL1 Proteine) plays important roles in determining malignant aggressiveness and outcome in prostate cancer (PCa (zeige FLVCR1 Proteine)), especially in androgen-independent PCa (zeige FLVCR1 Proteine) cells, via the regulation of cell proliferation, migration, and expression of VEGF-A (zeige VEGFA Proteine), -C, and COX-2.

  7. Study showed that VEGF-C levels are high in hypervolemic and low in euvolemic (and hypovolemic) chronic kidney disease patients; serum VEGF-C levels were significantly correlated with bioimpedance spectroscopy measurements

  8. Taken together, we suggest that ELK3 (zeige ELK3 Proteine) is an upstream regulator of the NF-kappaB (zeige NFKB1 Proteine) signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression.

  9. These results indicate that VEGF-C-induced MSC (zeige MSC Proteine) osteogenesis is mediated through VEGFR2 (zeige KDR Proteine) and VEGFR3 (zeige FLT4 Proteine), and followed the activation of the ERK (zeige EPHB2 Proteine)/RUNX2 (zeige RUNX2 Proteine) signaling pathway.

  10. Overexpression of vascular endothelial growth factor C (VEGF-C) in Kazakh esophageal squamous cell carcinoma (ESCC) was significantly associated with gender, depth of tumor invasion, lymph node metastasis and tumor clinical stage.

Mouse (Murine) Vascular Endothelial Growth Factor C (VEGFC) Interaktionspartner

  1. lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (zeige Adamts2 Proteine) and CCBE1 (zeige CCBE1 Proteine) spatially and temporally patterns developing lymphatics, and one in which VEGFD (zeige Figf Proteine) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth

  2. These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.

  3. Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK (zeige PTK2 Proteine)-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).

  4. Data show that heparanase-1 (HPA-1 (zeige HPSE Proteine)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Proteine)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (zeige SDC1 Proteine)/VEGF-C complex into the medium of hepatocarcinoma cell.

  5. Data show that in the MCF-7 breast cancer cell line, only MT1X (zeige MT1X Proteine) metallothioneins (MTs (zeige NEU2 Proteine)) positively correlated with vascular endothelial growth factor C (VEGFC).

  6. The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (zeige TGFB1 Proteine) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.

  7. The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.

  8. MT1-MMP (zeige MMP14 Proteine) directly cleaves LYVE-1 (zeige LYVE1 Proteine) on lymphatic endothelial cells to inhibit LYVE-1 (zeige LYVE1 Proteine)-mediated lymphangiogenic responses and restrains the production of VEGF-C.

  9. HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (zeige FGF1 Proteine)-C production from macrophages through Toll-like receptor 4 (zeige TLR4 Proteine)-dependent signal pathway

  10. Results showed that the VEGF-C/VEGFR-3 (zeige FLT4 Proteine) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus

VEGFC Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

Alternative names and synonyms associated with VEGFC

  • vascular endothelial growth factor c (vegfc)
  • vascular endothelial growth factor C (VEGFC)
  • vascular endothelial growth factor C (vegfc)
  • vascular endothelial growth factor C (Vegfc)
  • vascular endothelial growth factor C-like (LOC100525960)
  • AW228853 Protein
  • Flt4-L Protein
  • VEGF-C Protein
  • VEGFC Protein
  • VRP Protein
  • xvegf-c Protein

Bezeichner auf Proteinebene für VEGFC

vascular endothelial growth factor C , vascular endothelial growth factor c , FLT4 ligand DHM , VEGF-C , vascular endothelial growth factor-related protein , VRP , flt4 ligand , flt4-L , vascular endothelial growth factor C isoform 129 , vascular endothelial growth factor C isoform 184

GENE ID SPEZIES
403049 Danio rerio
699502 Macaca mulatta
100380462 Salmo salar
734331 Xenopus laevis
100127470 Sus scrofa
7424 Homo sapiens
22341 Mus musculus
114111 Rattus norvegicus
100338211 Oryctolagus cuniculus
100724469 Cavia porcellus
282122 Bos taurus
482932 Canis lupus familiaris
422573 Gallus gallus
101105629 Ovis aries
100525960 Sus scrofa
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