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Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN413872
Werchau, Toberer, Enk, Dammann, Helmbold: Merkel cell carcinoma induces lymphatic microvessel formation. in Journal of the American Academy of Dermatology 2011
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Vegfc acts through ERK (zeige MAPK1 Proteine) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (zeige MT2 Proteine) in angiogenesis, but also propose Mt2 (zeige MT2 Proteine) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (zeige MAFB Proteine) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (zeige CCBE1 Proteine), and Vegfc-driven sprouting is enhanced by local Ccbe1 (zeige CCBE1 Proteine) overexpression. Moreover, Vegfc- and Vegfr3 (zeige FLT4 Proteine)-dependent Erk (zeige MAPK1 Proteine) signaling is impaired in the absence of Ccbe1 (zeige CCBE1 Proteine).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (zeige FLT4 Proteine) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.
VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (zeige RLN1 Proteine) and recombinant human relaxin-2 (zeige RLN1 Proteine) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
In multivariate analysis, only serum VEGF-A (zeige VEGFA Proteine) correlated to diabetes duration, whereas VEGF-C only correlated to HbA1c and fasting blood glucose.
This study reports that human dendritic cells produce VEGF-C, a cytokine with potent pro-lymphangiogenic activity when stimulated with IFN-gamma (zeige IFNG Proteine)
Association of coexpressed high levels of VEGF-C and active MMP-9 (zeige MMP9 Proteine) with lymphatic spreading and local invasiveness of Papillary thyroid carcinoma (PTC (zeige F9 Proteine)) suggests their potential usefulness as predictive biomarkers of aggressive PTC (zeige F9 Proteine) behavior.
Data show that VEGF-C, VEGF-D (zeige Figf Proteine), and VEGFR-3 (zeige FLT4 Proteine) were expressed in a substantial percentage of breast carcinomas.
By treating LECs with VEGF (zeige VEGFA Proteine)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (zeige JUN Proteine)' transcription factors that showed a rapid transient upregulation VEGFR-3 (zeige FLT4 Proteine) stimulation. these results reveal an important and unanticipated role of HOXD10 (zeige HOXD10 Proteine) in the regulation of VEGFR-3 (zeige FLT4 Proteine) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.
High VEGFC expression is associated with angiogenesis and lymphangiogenesis.
Adiponectin promoted VEGF-C expression and secretion in human chondrosarcoma cells.
HuR (zeige ELAVL1 Proteine) plays important roles in determining malignant aggressiveness and outcome in prostate cancer (PCa (zeige FLVCR1 Proteine)), especially in androgen-independent PCa (zeige FLVCR1 Proteine) cells, via the regulation of cell proliferation, migration, and expression of VEGF-A (zeige VEGFA Proteine), -C, and COX-2.
Study showed that VEGF-C levels are high in hypervolemic and low in euvolemic (and hypovolemic) chronic kidney disease patients; serum VEGF-C levels were significantly correlated with bioimpedance spectroscopy measurements
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (zeige Adamts2 Proteine) and CCBE1 (zeige CCBE1 Proteine) spatially and temporally patterns developing lymphatics, and one in which VEGFD (zeige Figf Proteine) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK (zeige PTK2 Proteine)-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (zeige HPSE Proteine)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Proteine)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (zeige SDC1 Proteine)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (zeige MT1X Proteine) metallothioneins (MTs (zeige NEU2 Proteine)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (zeige TGFB1 Proteine) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
MT1-MMP (zeige MMP14 Proteine) directly cleaves LYVE-1 (zeige LYVE1 Proteine) on lymphatic endothelial cells to inhibit LYVE-1 (zeige LYVE1 Proteine)-mediated lymphangiogenic responses and restrains the production of VEGF-C.
HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (zeige FGF1 Proteine)-C production from macrophages through Toll-like receptor 4 (zeige TLR4 Proteine)-dependent signal pathway
Results showed that the VEGF-C/VEGFR-3 (zeige FLT4 Proteine) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184