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Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.
PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice
platelet activation through GPVI (zeige GP6 ELISA Kits) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (zeige PLCG1 ELISA Kits) levels are insufficient to support responsiveness, but that PLCgamma1 (zeige PLCG1 ELISA Kits) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.
amarogentin prevents platelet activation through the inhibition of PLC (zeige HSPG2 ELISA Kits) gamma2-PKC (zeige PKC ELISA Kits) cascade and MAPK (zeige MAPK1 ELISA Kits) pathway
PLCgamma2 and protein kinase C (zeige PKC ELISA Kits) are important upstream signals that regulate myelopoiesis through cytokines.
inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2.
down-regulation of PLCgamma2-beta-catenin (zeige CTNNB1 ELISA Kits) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.
a novel role of the PLCgamma2-IP(3)-Ca(2 (zeige CA2 ELISA Kits)+) cascade in the LPS (zeige TLR4 ELISA Kits)-induced innate immune response pathway where release of intracellular Ca(2 (zeige CA2 ELISA Kits)+) mediates TLR4 (zeige TLR4 ELISA Kits) trafficking and subsequent activation of IRF3 (zeige IRF3 ELISA Kits).
VapB (zeige VAPB ELISA Kits) positively regulates RANKL (zeige TNFSF11 ELISA Kits)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (zeige CA2 ELISA Kits)+)-NFAT (zeige NFATC1 ELISA Kits) signaling
PLCgamma2 deficiency impairs Dectin-2 (zeige CLEC6A ELISA Kits)-induced NF-kappaB (zeige NFKB1 ELISA Kits) and MAPK (zeige MAPK1 ELISA Kits) activation in response to fungal infection
Data show that protein-altering changes are in PLCG2, ABI3 (zeige ABI3 ELISA Kits), and TREM2 (zeige TREM2 ELISA Kits) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC (zeige HSPG2 ELISA Kits)[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1 (zeige IL1A ELISA Kits)[beta]).
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (zeige BCR ELISA Kits) and converging on PLCgamma2 through Rac (zeige AKT1 ELISA Kits) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).
Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.
amarogentin prevents platelet activation through the inhibition of PLC (zeige HSPG2 ELISA Kits) gamma2-PKC cascade and MAPK (zeige MAPK1 ELISA Kits) pathway
PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.
The autoinhibitory C-terminal SH2 domain of phospholipase C (zeige PLC ELISA Kits)-gamma2 stabilizes B cell receptor signalosome assembly.
The relationship between upstream tyrosine kinase (zeige TXK ELISA Kits) SYK (zeige SYK ELISA Kits) and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls.
Single-nucleotide polymorphisms in PLCG2 gene is associated with breast cancer risk after menopausal hormone replacement therapy.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
, phosphoinositide phospholipase C-gamma-2
, phospholipase C-gamma-2
, phosphoinositide phospholipase C
, phospholipase C-IV
, phosphatidylinositol-specific phospholipase C