PDGFA Proteine (PDGFA)

Bezeichnung:
Platelet-Derived Growth Factor alpha Polypeptide Proteine (PDGFA)
Auf www.antikoerper-online.de finden Sie aktuell 42 Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) Proteine von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PDGFA Antikörper (92) und PDGFA Kits (53) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 197 PDGFA Produkte verfügbar.
Synonyme:
pdgf, PDGF-A, PDGF1, pdgfa, pdgfa-2, PDGFACP, zgc:100777
alle Proteine anzeigen Gen GeneID UniProt
PDGFA 18590 P20033
PDGFA 5154 P04085
PDGFA 25266 P28576

Weitere Synonyme anzeigen

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Am meisten referenzierte PDGFA Proteine

  1. Human PDGFA Protein expressed in Wheat germ - ABIN1314496 : Paule, Nebl, Webb, Vollenhoven, Rombauts, Nie: Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation. in Molecular human reproduction 2015 (PubMed)

Weitere Proteine zu PDGFA Interaktionspartnern

Zebrafish Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) Interaktionspartner

  1. Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation

Mouse (Murine) Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) Interaktionspartner

  1. These studies uncover PI3K/AKT2 (zeige AKT2 Proteine) as a direct PDGFA target that is activated in adipocyte stem cells.

  2. stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor (zeige PDGFRB Proteine) alphalpha in cardiac interstitial mesenchymal cells

  3. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4 (zeige BMP4 Proteine)-induced adverse effect on endothelial cell function through SMAD1 (zeige SMAD1 Proteine)/5- and SMAD4 (zeige SMAD4 Proteine)-dependent mechanisms.

  4. Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 (zeige FGF2 Proteine) and platelet-derived growth factor receptor alpha (zeige PDGFRA Proteine).

  5. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR (zeige PDGFRB Proteine) signaling activation.

  6. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts.

  7. Platelet-derived growth factor mediates interleukin-13 (zeige IL13 Proteine)-induced collagen I production in mouse airway fibroblasts.

  8. senescent cells have a role in optimal wound healing through secretion of PDGF-AA

  9. leading to a PDGF-responsive SRF-driven transcriptional program in the midface

  10. Platelet-derived growth factor plays an integral role in mediating TGF-beta1 (zeige TGFB1 Proteine)-dependent mesenchymal stem cell stiffening.

Human Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) Interaktionspartner

  1. PDGFAA in tumor drainage and HER2 (zeige ERBB2 Proteine) in peripheral vein blood may have roles in synchronous liver metastasis of colorectal cancer

  2. Insulin (zeige INS Proteine) treatment caused sustained Akt (zeige AKT1 Proteine) activity, whereas EGF (zeige EGF Proteine) or PDGF-AA promoted transient signaling; PDGF-BB produced sustained responses at higher concentrations.Transient responses to EGF (zeige EGF Proteine) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (zeige IGF1 Proteine) caused full Akt (zeige AKT1 Proteine) activation

  3. these findings suggest that IGFBP-3 (zeige IGFBP3 Proteine) suppresses transcription of EGR1 (zeige EGR1 Proteine) and its target genes bFGF (zeige FGF2 Proteine) and PDGF through inhibiting IGF-1 (zeige IGF1 Proteine)-dependent ERK (zeige EPHB2 Proteine) and AKT (zeige AKT1 Proteine) activation.

  4. Based on a luciferase reporter assay, plateletderived growth factorA (PDGFA) was identified as a direct target gene of miR375. Additionally, overexpression of PDGFA significantly reversed the effect of miR375 on cell migration and invasion in oral squamous cell carcinoma cell.

  5. The highest PDGF AA levels were found in mothers of fetuses with hypoplastic left heart syndrome . These findings may be useful in screening for congenital heart defects (CCHDs) and offer insight into their association with nuchal translucency

  6. Low concentration of PDGF-AB showed synergism with IFN-alpha (zeige IFNA Proteine) in IFN-beta (zeige IFNB1 Proteine) and -gamma induction.

  7. downregulated Rab5a (zeige RAB5A Proteine) led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF significantly rescued these phenomena caused by siRNA against Rab5a (zeige RAB5A Proteine)

  8. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB (zeige PDGFB Proteine), PDGFC (zeige PDGFC Proteine) and PDGFD (zeige PDGFD Proteine)) that reside on chromosomes 7, 22, 4 and 11.

  9. TLR-stimulated pancreatic cancer cells were specifically investigated for activated signaling pathways of VEGF (zeige VEGFA Proteine)/PDGF and anti-apoptotic Bcl-xL (zeige BCL2L1 Proteine) expression as well as tumor cell growth.

  10. Nox4 (zeige NOX4 Proteine) and Duox1/Duox2 (zeige DUOX1 Proteine) mediate redox activation of mesenchymal cell migration by PDGF.

Xenopus laevis Platelet-Derived Growth Factor alpha Polypeptide (PDGFA) Interaktionspartner

  1. When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it.

PDGFA Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis\; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

Alternative names and synonyms associated with PDGFA

  • platelet-derived growth factor alpha polypeptide (PDGFA)
  • platelet-derived growth factor alpha a (pdgfaa)
  • platelet-derived growth factor alpha polypeptide (pdgfa)
  • collagen alpha-2(I) chain-like (LOC100735371)
  • platelet derived growth factor, alpha (Pdgfa)
  • platelet-derived growth factor alpha polypeptide (Pdgfa)
  • Platelet-derived growth factor subunit A-like (LOC100352388)
  • platelet-derived growth factor subunit A-like (LOC100519764)
  • pdgf Protein
  • PDGF-A Protein
  • PDGF1 Protein
  • pdgfa Protein
  • pdgfa-2 Protein
  • PDGFACP Protein
  • zgc:100777 Protein

Bezeichner auf Proteinebene für PDGFA

platelet-derived growth factor subunit A , platelet-derived growth factor alpha polypeptide , PDGF subunit A , PDGF-1 , platelet-derived growth factor A chain , PDGF A-chain , platelet-derived growth factor alpha chain , platelet-derived growth factor alpha isoform 2 preproprotein , Platelet-derived growth factor A chain , platelet derived growth factor, alpha , PDGF-A (S1) , platelet-derived growth factor A chain long form , platelet-derived growth factor A chain short form type 1 , platelet-derived growth factor A chain short form type 2 , platelet-derived growth factor A-chain , platelet-derived growth factor A chain, long form

GENE ID SPEZIES
491597 Canis lupus familiaris
378480 Danio rerio
100038202 Xenopus (Silurana) tropicalis
100735371 Cavia porcellus
18590 Mus musculus
5154 Homo sapiens
25266 Rattus norvegicus
505908 Bos taurus
374196 Gallus gallus
397765 Xenopus laevis
100352388 Oryctolagus cuniculus
100519764 Sus scrofa
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