MERTK Proteine (MERTK)

Bezeichnung:
C-Mer Proto-Oncogene Tyrosine Kinase Proteine (MERTK)
Auf www.antikoerper-online.de finden Sie aktuell 25 C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MERTK Antikörper (213) und MERTK Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 277 MERTK Produkte verfügbar.
Synonyme:
C-EYK, c-mer, DKFZp469D2215, Eyk, Mer, MERTK, nmf12, Nyk, rdy, RP38, si:ch1073-268l12.2
alle Proteine anzeigen Gen GeneID UniProt
MERTK 10461 Q12866
MERTK 17289 Q60805
MERTK 65037 P57097

Weitere Synonyme anzeigen

MERTK Proteine (MERTK) nach Spezies

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Am meisten referenzierte MERTK Proteine

  1. Mouse (Murine) MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2007918 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Zeige alle 3 Referenzen für 2007918

  2. Mouse (Murine) MERTK Protein expressed in Human Cells - ABIN2007915 : Gal, Li, Thompson, Weir, Orth, Jacobson, Apfelstedt-Sylla, Vollrath: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. in Nature genetics 2000 (PubMed)
    Zeige alle 3 Referenzen für 2007915

  3. Human MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2002536 : Oppermann, Gnad, Olsen, Hornberger, Greff, Kéri, Mann, Daub: Large-scale proteomics analysis of the human kinome. in Molecular & cellular proteomics : MCP 2009 (PubMed)
    Zeige alle 3 Referenzen für 2002536

Weitere Proteine zu MERTK Interaktionspartnern

Human C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Interaktionspartner

  1. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 (zeige TYRO3 Proteine) and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 (zeige TYRO3 Proteine) and Mer expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 (zeige TYRO3 Proteine) and Mer mRNA and increased shedding of sTyro3 and sMer.

  2. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (zeige TXK Proteine) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  3. Small molecule and antibody inhibitors of AXL (zeige AXL Proteine) and MER have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL (zeige AXL Proteine) and MER targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.

  4. A 48 bp insertion sequence was buried within the breakpoint; 18 bps shared homology to MIR4435-2HG and LINC00152, and 30 bp mapped to MERTK. The deletion cosegregated with arRP in the family.

  5. In this paper, we review the biology of the Gas6 (zeige GAS6 Proteine)/Tyro3 (zeige TYRO3 Proteine), Axl (zeige AXL Proteine), and MerTK(collectively named TAM (zeige CCNA1 Proteine) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .

  6. The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).

  7. We report a novel missense mutation (c.3G>A, p.0?) in the MERTK gene that causes severe vision impairment in a patient.

  8. Utilizing an ex vivo co-cultivation approach to model key cellular and molecular events found in vivo during infarction, cardiomyocyte phagocytosis was found to be inefficient, in part due to myocyte-induced shedding of macrophage MERTK

  9. Upon differentiation of these iPSC towards RPE (zeige RPE Proteine), patient-specific RPE (zeige RPE Proteine) cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models

  10. The current study demonstrates the contribution of the TAM (zeige CCNA1 Proteine) receptor MerTK to the phagocytosis of myelin by human adult microglia and monocyte-derived macrophages.

Mouse (Murine) C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Interaktionspartner

  1. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (zeige TYRO3 Proteine) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  2. these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages

  3. the reciprocal activation of Axl (zeige AXL Proteine) and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

  4. Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (zeige RPS19 Proteine)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.

  5. Axl (zeige AXL Proteine), Mertk and Tyro3 (zeige TYRO3 Proteine) receptors are not required for Zika virus entry and infection.

  6. Signaling through the Mer (zeige ERH Proteine) proto-oncogene (zeige RAB1A Proteine) tyrosine kinase (zeige TYRO3 Proteine) (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM (zeige NPC1 Proteine)) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM (zeige NPC1 Proteine) biosynthetic enzyme, 5-lipoxygenase (zeige ALOX5 Proteine).

  7. These studies define the clearance of infected, apoptotic neutrophils by dendritic cells and Mer (zeige ERH Proteine) receptor signaling as central to the early immune evasion strategies of L. major.

  8. Tyro3 (zeige TYRO3 Proteine) gene dosage modulates Mertk-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (zeige TYRO3 Proteine) in RPE (zeige RPE Proteine) phagocytosis, and suggest that an eQTL (zeige EQTN Proteine) can modify a recessive Inherited photoreceptor degenerations.

  9. Activation of Mertk synergized with interferon-beta (zeige IFNB1 Proteine) to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells.

  10. results establish TAM (zeige CCNA1 Proteine) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

MERTK Protein Überblick

Protein Überblick

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Alternative names and synonyms associated with MERTK

  • c-mer proto-oncogene tyrosine kinase (MERTK)
  • c-mer proto-oncogene tyrosine kinase (LOC100219161)
  • c-mer proto-oncogene tyrosine kinase (mertk)
  • c-mer proto-oncogene tyrosine kinase (Mertk)
  • C-EYK Protein
  • c-mer Protein
  • DKFZp469D2215 Protein
  • Eyk Protein
  • Mer Protein
  • MERTK Protein
  • nmf12 Protein
  • Nyk Protein
  • rdy Protein
  • RP38 Protein
  • si:ch1073-268l12.2 Protein

Bezeichner auf Proteinebene für MERTK

c-eyk proto-oncogene , tyrosine-protein kinase Mer , c-mer proto-oncogene tyrosine kinase , MER receptor tyrosine kinase , tyrosine-protein kinase Mer-like , STK kinase , proto-oncogene c-Mer , receptor tyrosine kinase MerTK , Tyro 12 , proto-oncogene tyrosine-protein kinase Mer , Receptor tyrosine tinase gene probably the gene for Rdy , proto-oncogene tyrosine-protein kinase MER , retinal dystrophy

GENE ID SPEZIES
395836 Gallus gallus
459492 Pan troglodytes
483060 Canis lupus familiaris
504429 Bos taurus
698330 Macaca mulatta
100171862 Pongo abelii
100219161 Taeniopygia guttata
100322133 Danio rerio
100476239 Ailuropoda melanoleuca
10461 Homo sapiens
17289 Mus musculus
65037 Rattus norvegicus
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