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GDNF Proteine (GDNF)

Glial Cell Line Derived Neurotrophic Factor Proteine (GDNF)
Auf finden Sie aktuell 61 Glial Cell Line Derived Neurotrophic Factor (GDNF) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GDNF Antikörper (120) und GDNF Kits (82) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 273 GDNF Produkte verfügbar.
alle Proteine anzeigen Gen GeneID UniProt
GDNF 25453 Q07731
GDNF 2668 P39905
GDNF 14573 P48540

Weitere Synonyme anzeigen

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Am meisten referenzierte GDNF Proteine

  1. Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN2667420 : Carnicella, Ron: GDNF--a potential target to treat addiction. in Pharmacology & therapeutics 2009 (PubMed)
    Zeige alle 5 Referenzen für ABIN2667420

  2. Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN1686334 : Pelletier, Lagacé, St-Amour, Arsenault, Cisbani, Chabrat, Fecteau, Lévesque, Cicchetti: The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2015 (PubMed)

Weitere Proteine zu GDNF Interaktionspartnern

Human Glial Cell Line Derived Neurotrophic Factor (GDNF) Interaktionspartner

  1. results show that the uPA (zeige PRAP1 Proteine)/uPAR (zeige PLAUR Proteine)/LRP1 (zeige LRP1 Proteine) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury

  2. In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.

  3. The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (zeige MMP9 Proteine) activity and uPA (zeige PRAP1 Proteine) expression through decreasing of IKK-beta (zeige IKBKB Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.

  4. Suppression of miR (zeige MLXIP Proteine)-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.

  5. These studies identify uPA (zeige PRAP1 Proteine)-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA (zeige PRAP1 Proteine) mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.

  6. Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.

  7. No correlations between the levels of serum neurotrophins and the severity of ADHD were observed. These results suggest that elevated serum GDNF and NTF3 (zeige NTF3 Proteine) levels may be related to ADHD in children.

  8. BDNF (zeige BDNF Proteine) and GDNF interact with the 5-HT (zeige DDC Proteine)-system of the brain through feedback mechanisms engaged in autoregulation

  9. We concluded that overexpression of MMP-3 (zeige MMP3 Proteine) and uPA (zeige PRAP1 Proteine), altogether with diminished expression of PAI-1 (zeige SERPINE1 Proteine) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.

  10. The up-regulation of uPA (zeige PRAP1 Proteine) mRNAs was correlated with high-risk clinicopathological features, including extrathyroid invasion, loss of cellular polarity/cohesiveness, and the BRAF (zeige BRAF Proteine)(V600E) mutation.

Mouse (Murine) Glial Cell Line Derived Neurotrophic Factor (GDNF) Interaktionspartner

  1. GDNF signals were able to induce the stratified aggregate formation of GFRalpha1 (zeige GFRA1 Proteine)-positive undifferentiated spermatogonia

  2. Our results show the existence of two subpopulations of peptidergic nociceptors characterized by the presence of CGRP (zeige CALCA Proteine), one expressing BDNF (zeige BDNF Proteine) (plus SP), the other expressing GDNF (plus SST (zeige SST Proteine)), suggesting a different role for these two neurotrophic factors in the discrimination of specific painful stimuli modalities.

  3. The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (zeige BDNF Proteine) potentially leading to alterations in neural development.

  4. The Gdnf cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of undifferentiated spermatogonia

  5. Our results reveal the role of GDNF in nigrostriatal dopamine system postnatal development and adult function, and highlight the importance of correct spatial expression of GDNF

  6. Mice overexpressing GDNF had significantly reduced P62 (zeige GTF2H1 Proteine) protein levels suggestive of accelerated autophagy. They also had reduced PPAR-gamma (zeige PPARG Proteine) and CD36 (zeige CD36 Proteine) gene expression and protein levels, and lower expression of mRNA coding for enzymes involved lipogenesis.

  7. This study demonstrated that decrease in mRNA level of GDNF in brain in microgravity.

  8. GDNF signaling in the urogenital sinus increases proliferation.

  9. Results show that in the inflamed intestine, smooth muscle proliferation supports the enteric nervous system , and thus its own re-innervation, by expression of GDNF

  10. Parkin (zeige PARK2 Proteine) and the RET (zeige RET Proteine) signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars (zeige EPRS Proteine) compacta dopaminergic neurons and their innervation in the striatum.

GDNF Protein Überblick

Protein Überblick

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GDNF

  • glial cell derived neurotrophic factor (Gdnf)
  • glial cell derived neurotrophic factor (GDNF)
  • glial cell line derived neurotrophic factor (Gdnf)
  • plasminogen activator, urokinase (PLAU)
  • AI385739 Protein
  • ATF Protein
  • ATF1 Protein
  • ATF2 Protein
  • BDPLT5 Protein
  • HFB1-GDNF Protein
  • HSCR3 Protein
  • QPD Protein
  • u-PA Protein
  • UPA Protein
  • URK Protein

Bezeichner auf Proteinebene für GDNF

ATF , Glial cell line derived neutrophic factor , astrocyte-derived trophic factor , glial cell line derived neurotrophic factor , glial cell line-derived neurotrophic factor , mGDNF , neurotrophic factor , U-plasminogen activator , plasminogen activator, urinary , urokinase-type plasminogen activator

25453 Rattus norvegicus
2668 Homo sapiens
14573 Mus musculus
5328 Homo sapiens
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