Ephrin B2 Proteine (EFNB2)

Bezeichnung:
Ephrin B2 Proteine (EFNB2)
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Synonyme:
efnb2, efnb2a, efnb2b, ELF-2, ephrin-B2, ephrinB2, Epl5, EPLG5, Htk-L, HTKL, LERK-5, LERK5, MGC68890, NLERK-1
alle Proteine anzeigen Gen GeneID UniProt
EFNB2 13642 P52800
EFNB2 306636  
EFNB2 1948 P52799

Weitere Synonyme anzeigen

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Am meisten referenzierte Ephrin B2 Proteine

  1. Mouse (Murine) Ephrin B2 Protein expressed in Human Cells - ABIN2008045 : Flanagan, Vanderhaeghen: The ephrins and Eph receptors in neural development. in Annual review of neuroscience 1998 (PubMed)

  2. Human Ephrin B2 Protein expressed in Wheat germ - ABIN1352413 : Kwan Tat, Pelletier, Amiable, Boileau, Lavigne, Martel-Pelletier: Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. in Arthritis research & therapy 2009 (PubMed)

Weitere Proteine zu Ephrin B2 Interaktionspartnern

Xenopus laevis Ephrin B2 (EFNB2) Interaktionspartner

  1. It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.

  2. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 (zeige ADAM10 Proteine) and flotillin-1 (zeige FLOT1 Proteine).

Mouse (Murine) Ephrin B2 (EFNB2) Interaktionspartner

  1. During urogenital development, different modes of Eph (zeige EPHA1 Proteine)/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.

  2. Male Efnb2 knockout mice presented reduced blood pressure. Region from aa 313 to aa 331 of EFNB2 was essential for reverse signaling regulating VSMC contractility.

  3. Suggest role for ephrinB2/EphB4 (zeige EPHB4 Proteine) signaling in the maintenance of neurovascular homeostasis and show that EphrinB2 activation promotes vascular repair mechanisms and reduces brain swelling after mild cerebral ischemia.

  4. The Eph (zeige EPHA1 Proteine)/ephrin-B2-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.

  5. Control of abscission requires Eph (zeige EPHA1 Proteine) kinase activity, and Src (zeige SRC Proteine) and citron kinase (zeige CIT Proteine) (CitK) are downstream effectors in the Eph (zeige EPHA1 Proteine)-induced signal transduction cascade

  6. The Netrin-1 (zeige NTN1 Proteine) and ephrin-B2 synergistic growth cone responses involve the potentiation of Src (zeige SRC Proteine) family kinase signaling, a common effector of both pathways.

  7. in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development

  8. the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.

  9. our study uncovered a novel cell autonomous role for ephrinB2 in lateral motor column motoneurons

  10. These data indicate that ephrinB2/EphB4 (zeige EPHB4 Proteine) signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.

Human Ephrin B2 (EFNB2) Interaktionspartner

  1. Study shows that EFNB2 is overexpressed in head and neck squamous cell carcinoma, pancreatic adenocarcinoma, and urothelial bladder carcinoma, and its overexpression correlates with poor survival of the cancer patients.

  2. Five SNPs in the 3' region of the EFNB2 were in linkage disequilibrium and significantly associated with hypertension for male but not female subjects.

  3. These results indicate a novel mechanism of ephrin-Eph (zeige EPHA1 Proteine) signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2 (zeige EPHB2 Proteine)(+)extracellular vesicles in neural development and synapse physiology.

  4. Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.

  5. miR (zeige MLXIP Proteine)-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR (zeige MLXIP Proteine)-137, as a risk factor for schizophrenia

  6. 5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src (zeige SRC Proteine)-ERK (zeige EPHB2 Proteine) pathway, and drives EMT (zeige ITK Proteine) via the Src (zeige SRC Proteine)-FAK (zeige PTK2 Proteine) pathway.

  7. Together, these findings suggest that CCL2 (zeige CCL2 Proteine), RARRES2 (zeige RARRES2 Proteine) and EFNB2 are host cell factors involved in respiratory syncytial virus replication.

  8. These genes may be potential biomarkers for identification of subclinical lymph node involvement in papillary thyroid carcinoma (PTC (zeige F9 Proteine))

  9. Results suggest a potential signalling hierarchy between Delta-like 1 (zeige DLL1 Proteine) and ephrin-B2 ligands, as neural stem cells adopt the Delta-like 1 (zeige DLL1 Proteine) phenotype of stem cell maintenance on simultaneous presentation of both signals.

  10. EfnB2 is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EfnB2 signaling repressing JNK3 (zeige MAPK10 Proteine) activity via STAT1 (zeige STAT1 Proteine).

Pig (Porcine) Ephrin B2 (EFNB2) Interaktionspartner

  1. The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.

Ephrin B2 (EFNB2) Protein Überblick

Protein Überblick

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

Alternative names and synonyms associated with Ephrin B2 (EFNB2)

  • ephrin-B2 (EFNB2)
  • ephrin-B2 precursor (efnb2)
  • ephrin-B2 (efnb2)
  • ephrin-B2 (efnb2-a)
  • ephrin B2 (LOC100357479)
  • ephrin B2 (Efnb2)
  • efnb2 Protein
  • efnb2a Protein
  • efnb2b Protein
  • ELF-2 Protein
  • ephrin-B2 Protein
  • ephrinB2 Protein
  • Epl5 Protein
  • EPLG5 Protein
  • Htk-L Protein
  • HTKL Protein
  • LERK-5 Protein
  • LERK5 Protein
  • MGC68890 Protein
  • NLERK-1 Protein

Bezeichner auf Proteinebene für Ephrin B2 Proteine (EFNB2)

ephrin-B2 , ephrin-B2 precursor , ephrin B2 , ephrin-B2a , ephrin-B2b , EPH-related receptor tyrosine kinase ligand 5 , HTK ligand , LERK-5 , eph-related receptor tyrosine kinase ligand 5 , ligand of eph-related kinase 5

GENE ID SPEZIES
395625 Gallus gallus
779011 Xenopus laevis
100064730 Equus caballus
100101723 Xenopus (Silurana) tropicalis
100135769 Felis catus
379645 Xenopus laevis
735430 Pan troglodytes
100141484 Xenopus laevis
100357479 Oryctolagus cuniculus
13642 Mus musculus
306636 Rattus norvegicus
1948 Homo sapiens
611745 Canis lupus familiaris
100135673 Sus scrofa
100139818 Bos taurus
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