Ephrin B1 Proteine (EFNB1)

Bezeichnung:
Ephrin B1 Proteine (EFNB1)
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Synonyme:
Cek5-L, cfnd, cfns, EFL-3, efl3, EFNB1, efnb1-A, Elk-L, ephrinB1, Epl2, eplg2, LERK-2, lerk2, Stra1
alle Proteine anzeigen Gen GeneID UniProt
EFNB1 25186  
EFNB1 13641 P52795
EFNB1 1947 P98172

Weitere Synonyme anzeigen

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Am meisten referenzierte Ephrin B1 Proteine

  1. Human Ephrin B1 Protein expressed in HEK-293 Cells - ABIN2180995 : Brückner, Pablo Labrador, Scheiffele, Herb, Seeburg, Klein: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. in Neuron 1999 (PubMed)
    Zeige alle 3 Referenzen für 2180995

  2. Human Ephrin B1 Protein expressed in Escherichia coli (E. coli) - ABIN667541 : Kalo, Yu, Pasquale: In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 2 Referenzen für 667541

  3. Human Ephrin B1 Protein expressed in Human Cells - ABIN2003560 : Flanagan, Vanderhaeghen: The ephrins and Eph receptors in neural development. in Annual review of neuroscience 1998 (PubMed)

Weitere Proteine zu Ephrin B1 Interaktionspartnern

Mouse (Murine) Ephrin B1 (EFNB1) Interaktionspartner

  1. These results indicate a novel mechanism of ephrin-Eph (zeige EPHA1 Proteine) signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2 (zeige EPHB2 Proteine)(+) extracellular vesicles in neural development and synapse physiology.

  2. ephrin-B1-mediated cell segregation occurs in the early neuroepithelium.

  3. Results suggest the involvement of ephrin-B1 signaling in astrocyte-mediated remodeling of excitatory synapses following injury, which can be accomplished through ephrin-B1-mediated regulation of STAT3 (zeige STAT3 Proteine) signaling in astrocytes.

  4. Conditioned deletion of ephrinB1 and/or ephrinB2 (zeige EFNB2 Proteine) in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts.

  5. Efnb1 and Efnb2 in T cells are essential for pathogenic antibody production and for T cell migration to the inflamed paws in mice with collagen-induced arthritis.

  6. The EphB2 (zeige EPHB2 Proteine) and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction.

  7. EFNB1 contributes to the suppression of adipose inflammatory response. In obesity, reduction of adipose EFNB1 may accelerate the vicious cycle involved in adipose tissue inflammation.

  8. Overexpression of ephrin B1 in bone cells enhances bone mass.

  9. The results of this study demonstrated that ephrin-B1 inhibits nonradial migration of pyramidal neurons, thereby controlling the pattern of cortical columns.

  10. Ephrin-B1 and ephrin-B2 (zeige EFNB2 Proteine) expressed on thymocytes play an autonomous role in T cell development and, expressed on thymic epithelial cells (TECs), their nonautonomous roles are partially overlapping.

Zebrafish Ephrin B1 (EFNB1) Interaktionspartner

  1. bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate mesoderm (LPM), resulting in asymmetric positioning of the zebrafish liver.

Human Ephrin B1 (EFNB1) Interaktionspartner

  1. one novel (IVS2+3G>T) and one previously reported mutation (p.Gly151Ser) in EFNB1 Both patients were de novo cases without a family history of Craniofrontonasal syndrome.

  2. While ephrin-B1 deficiency leads to abnormal visual pathways in mice, it leaves the human visual system, apart from deficits in binocular vision, largely normal.

  3. that EphrinB1 (EFNB1) co-localizes with microtubules (MTs (zeige TIMM8A Proteine)) during all phases of the cell cycle.

  4. we report a family with a G151S mutation in the EFNB1 gene. The mutation was identified in two severely affected sisters and paradoxically in their clinically unaffected father.

  5. T cells from rheumatoid arthritis (RA) patients expressed higher EFNB1 mRNA levels, which correlated with RA symptoms and laboratory findings. Expression of EFNB1 in T cells might be a parameter for monitoring RA disease activity and treatment responses.

  6. Results indicate that EphrinB1 is uniquely dysregulated in medulloblastoma and promotes oncogenic responses in medulloblastoma cells, implicating ephrinB1 as a potential target

  7. EphB2 (zeige EPHB2 Proteine)/ephrin-B1 were invoked in dental pulp stem cells with TNF-alpha (zeige TNF Proteine) treatment via the JNK (zeige MAPK8 Proteine)-dependent pathway, but not NF-kB, p38 MAPK (zeige MAPK14 Proteine) or MEK (zeige MAP2K1 Proteine) signalling.

  8. Patients with EFNB1 mutations have a clear phenotype. This study will facilitate genetic counseling of parents and patients, and contribute to the diagnostic and screening process of patients with suspected CFNS.

  9. CNK1 (zeige CNKSR1 Proteine) mediates ephrinB1 signaling that promotes cell migration through RhoA (zeige RHOA Proteine) and JNK (zeige MAPK8 Proteine) activity.

  10. EphrinB1 expression is related to the metastasis of breast cancer and its enhanced expression confers a poor prognosis, suggesting that EphrinB1 may be a relevant therapeutic target in breast cancers.

Xenopus laevis Ephrin B1 (EFNB1) Interaktionspartner

  1. interactions between Smurfs and ephrinB1 regulates the maintenance of tissue boundaries through the control of ephrinB protein levels

  2. Results identify the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein.

  3. Ephrin-B1 and Wnt3A (zeige WNT3A Proteine) signaling contribute to region-specific neuronal plasticity in the developing optic tectum.

  4. Tyrosine-298 in ephrin B1 is required for binding Grb4 (zeige NCK2 Proteine).

  5. EphrinB1 reverse signaling is required to promote cellular movements into the eye field, and can rescue the FGF receptor (zeige FGFR2 Proteine)-induced repression of retinal fate. respectively.

  6. Gain- and loss-of-function experiments suggest that Xdsh (zeige DVL2 Proteine) associates with ephrinB1 and mediates ephrinB1 signalling through downstream members of the PCP (zeige PRCP Proteine) pathway during eye field formation.

  7. recruitment of STAT3 (zeige STAT3 Proteine) to ephrinB1, and its resulting Jak2 (zeige JAK2 Proteine)-dependent activation and transcription of reporter targets, reveals a signaling pathway from ephrinB1 to the nucle

  8. ephrinB1 associates with the Par (zeige AFG3L2 Proteine) polarity complex protein Par-6 (zeige PARD6A Proteine) and can compete with the small GTPase (zeige RACGAP1 Proteine) Cdc42 (zeige CDC42 Proteine) for association with Par-6 (zeige PARD6B Proteine).

  9. Data demonstrate that phosphorylation of tyrosines 324 and 325 of ephrin B1 disrupts the ephrinB1/Dishevelled (zeige DVL2 Proteine) interaction, thus modulating retinal progenitor movement that is dependent on the planar cell polarity pathway.

Ephrin B1 (EFNB1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

Alternative names and synonyms associated with Ephrin B1 (EFNB1)

  • ephrin-B1 (EFNB1)
  • ephrin B1 (Efnb1)
  • ephrin B1 (efnb1)
  • ephrin-B1 (efnb1)
  • Cek5-L Protein
  • cfnd Protein
  • cfns Protein
  • EFL-3 Protein
  • efl3 Protein
  • EFNB1 Protein
  • efnb1-A Protein
  • Elk-L Protein
  • ephrinB1 Protein
  • Epl2 Protein
  • eplg2 Protein
  • LERK-2 Protein
  • lerk2 Protein
  • Stra1 Protein

Bezeichner auf Proteinebene für Ephrin B1 Proteine (EFNB1)

ephrin-B1 , EPH-related receptor tyrosine kinase ligand 2 , ELK ligand , ELK-L , LERK-2 , CEK5 receptor ligand , Cek ligand , Cek5 ligand , stimulated by retinoic acid gene 1 protein , EFL-3 , eph-related receptor tyrosine kinase ligand 2 , ligand of eph-related kinase 2 , ephrin-B1 (EPH family ligand) , xlERK , CEK5 ligand , CEK5-L

GENE ID SPEZIES
473651 Pan troglodytes
694149 Macaca mulatta
25186 Rattus norvegicus
13641 Mus musculus
114377 Danio rerio
1947 Homo sapiens
394292 Xenopus laevis
395896 Gallus gallus
607410 Canis lupus familiaris
534413 Bos taurus
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