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showed that patients with SSc (zeige CYP11A1 Proteine) or SLE have AAb against EphB2, a protein involved in angiogenesis, and THEX1 (zeige ERI1 Proteine), a 3'-5' exoribonuclease involved in histone mRNA degradation. We have further identified a peptide from EphB2 as a specific and sensitive tool for SLE diagnosis
show that expression of EPHB2 and SNAIL1 (zeige SNAI1 Proteine) - an inducer of epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) - is anti-correlated in colorectal cancer cell lines and tumors
Tiam2 (zeige TIAM2 Proteine)/Rac (zeige AKT1 Proteine) are key components of EphB2 trans-endocytosis and are important for cell repulsion.
High expression of junctional adhesion molecule-A (zeige F11R Proteine) and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients.
Data show that activation of EphB2 receptor kinase arrests tau protein hyperphosphorylation through phosphatidylinositol 3-kinase (PI3K)/Akt protein-mediated glycogen synthase kinase-3beta (GSK-3beta) inhibition.
Expression of the Receptor Tyrosine Kinase (zeige RET Proteine) EphB2 on Dendritic Cells Is Modulated by Toll (zeige TLR4 Proteine)-Like Receptor Ligation but Is Not Required for T Cell Activation
Myosin 1 functions as an effector of EphB2/ephrinB signaling, controls cell morphology, and thereby cell repulsion.
EphB2 activation is required for ependymoma development as well as it inhibits differentiation and promotes proliferation of the transformed cell.
EphB2/ephrin-B1 (zeige EFNB1 Proteine) were invoked in dental pulp stem cells with TNF-alpha (zeige TNF Proteine) treatment via the JNK (zeige MAPK8 Proteine)-dependent pathway, but not NF-kB, p38 MAPK (zeige MAPK14 Proteine) or MEK (zeige MAP2K1 Proteine) signalling.
The results show an intricate interplay between p53 (zeige TP53 Proteine) and TGF-beta3 (zeige TGFB3 Proteine) whereby p53 (zeige TP53 Proteine) inhibits the TGF-beta3 (zeige TGFB3 Proteine)-induced expression of genes, e.g., EPHB2, to impede tumor cell invasion and migration
Overexpression of EphB2 also rescued the ADDLs-induced depletion of the expression of EphB2 and GluN2B (zeige GRIN2B Proteine)-containing NMDA receptors trafficking in cultured hippocampal neurons.
ephrin B3 (zeige EFNB3 Proteine)/EphB2 are obvious candidates for driving the Syk (zeige SYK Proteine)-dependent repulsive response.
The results of this study indicated that the decrease in spine density in the mPFC was associated with susceptibility to stress, and EphB2 downregulation in the mPFC increased the vulnerability to stress.
We here identify that EphB2 receptor tyrosine kinase (zeige ERBB3 Proteine), which is specifically expressed in glutamatergic neurons, is required for the innate fear responses in the neonatal brain.
Here, we identified the interaction sites of the EphB2 FN domain with ADDLs for the first time to develop a small (10 aa) peptide (Pep63) capable of blocking the EphB2-ADDL (zeige ADD3 Proteine) interaction.
EphB4 (zeige EPHB4 Proteine) plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 (zeige EFNB2 Proteine) can be effectively compensated, most possibly by other ephrins with similar chemical structures
Authors suggest that aging is accompanied by the upregulation of miR-204 in the hippocampus, which downregulates EphB2 and results in reduced surface and total NR1 expression.
Findings suggest that a combination of forward and reverse EphB1 (zeige EPHB1 Proteine)/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
Results demonstrate that EphB2 reverse signaling plays a unique and requisite role in inhibiting the development of opiate-dependent tolerance in vivo
During re-epithelialization ephrin-B1 (zeige EFNB1 Proteine) and its receptor EphB2 are both upregulated in vivo, just for the duration of repair.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
ephrin receptor EphB2
, EPH receptor B2
, ephrin type-B receptor 2-like
, EPH-like kinase 5
, developmentally-regulated Eph-related tyrosine kinase
, elk-related tyrosine kinase
, eph tyrosine kinase 3
, ephrin type-B receptor 2
, protein-tyrosine kinase HEK5
, renal carcinoma antigen NY-REN-47
, tyrosine-protein kinase TYRO5
, tyrosine-protein kinase receptor EPH-3
, neural kinase
, nuk receptor tyrosine kinase
, tyrosine-protein kinase receptor SEK-3
, embryo kinase 5 protein CEK5