anti-ALK (ALK) Antikörper

Bezeichnung:
anti-Anaplastic Lymphoma Receptor tyrosine Kinase Antikörper (ALK)
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Synonyme:
ALK, CD246, NBLST3, Tcrz
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus ALK ALK 11682 P97793
Anti-Human ALK ALK 238 Q9UM73
Anti-Ratte ALK ALK 266802  

Weitere Synonyme anzeigen

Weitere Antikörper gegen ALK Interaktionspartner

Mouse (Murine) Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Interaktionspartner

  1. ALKR1275Q cooperated with MYCN (zeige MYCN Antikörper) in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Antikörper)/BM-associated genes and by conferring malignant potentials to MYCN (zeige MYCN Antikörper)-expressing cells.

  2. ALK inhibitor alectinib inhibits tumor growth in a TH-MYCN transgenic neurob (zeige ARHGEF16 Antikörper)lastoma mouse model.

  3. Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice.

  4. An oral anaplastic lymphoma kinase (ALK) inhibitor.

  5. ALK knock out male mice exhibit hypogonadotropic hypogonadism.

  6. Ethanol activates ALK (and MDK (zeige MDK Antikörper)) signaling in the brain which regulates behaviors related to alcohol abuse.

  7. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

  8. Mutations in the ALK gene is associated with neuroblastoma (zeige ARHGEF16 Antikörper).

  9. Th-MYCN (zeige MYCN Antikörper) genetically-engineered murine models of neuroblastoma (zeige ARHGEF16 Antikörper) using MRI (zeige C7ORF49 Antikörper), we have identified a marked ALK(F1174L)-driven vascular phenotype.

  10. Reduced ALK1 (zeige ACVRL1 Antikörper) expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.

Human Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Interaktionspartner

  1. Our results suggest that the dynamic change in the numbers of circulating tumor cells (CTC) with ALK-CNG (zeige CNGA1 Antikörper) may be a predictive biomarker for crizotinib efficacy in ALK-rearranged non-small cell lung cancer (NSCLC)patients. Serial molecular analysis of CTC shows promise for real-time patient monitoring and clinical outcome prediction in this population.

  2. Studies indicate that aberrant AXL receptor tyrosine kinase (AXL (zeige AXL Antikörper)) signaling and development of an epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK F1174L)-driven neuroblastoma (zeige ARHGEF16 Antikörper) (NB) cells to TAE684 and its derivatives.

  3. Knockdown of SMYD2 (zeige SMYD2 Antikörper) as well as treatment with a SMYD2 (zeige SMYD2 Antikörper) inhibitor in two NSCLC cell lines with an EML4 (zeige EML4 Antikörper)-ALK gene significantly attenuated the phosphorylation levels of the EML4 (zeige EML4 Antikörper)-ALK protein.

  4. Data indicate that NPM (zeige NPM1 Antikörper)-ALK was distributed in equal amounts between the cytoplasm and the nucleus.

  5. The EML4 (zeige EML4 Antikörper)-ALK-mediated upregulation of HIF1alpha (zeige HIF1A Antikörper), HK2 (zeige HK2 Antikörper) and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4 (zeige EML4 Antikörper)-ALK-positive NSCLC cells.

  6. Results indicate that ALK expression, at both the RNA and the protein levels, is strongly associated with the WNT (zeige WNT2 Antikörper)-activated type of tumors and therefore may serve as a useful marker for the detection of this type of medulloblastoma. Importantly, ALK protein expression alone is also an indicator of good prognosis for medulloblastoma patients.

  7. Reverse transcription-polymerase chain reaction is a suitable method for detecting ALK translocations using cytology samples from patients with primary lung cancer.

  8. ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma (zeige ARHGEF16 Antikörper) cells.

  9. We assessed the prevalence of EML4 (zeige EML4 Antikörper)-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL (zeige ACLY Antikörper)), and the correlation with smoking history, thyroid transcription factor 1 (TTF1 (zeige NKX2-1 Antikörper)), gender and age

  10. Nucleophosmin (zeige NPM1 Antikörper)-anaplastic lymphoma kinase serves as the founding member of the ALK fusion protein family, and its role in malignant cell transformation is by far the best characterized and, thus, is the main focus of this review. [review]

ALK Antigen-Profil

Beschreibung des Gens

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).

Alternative names and synonyms associated with ALK

  • anaplastic lymphoma kinase (Alk) Antikörper
  • anaplastic lymphoma receptor tyrosine kinase (ALK) Antikörper
  • ALK tyrosine kinase receptor-like (LOC536642) Antikörper
  • anaplastic lymphoma receptor tyrosine kinase (Alk) Antikörper
  • ALK Antikörper
  • CD246 Antikörper
  • NBLST3 Antikörper
  • Tcrz Antikörper

Bezeichner auf Proteinebene für ALK

ALK tyrosine kinase receptor , anaplastic lymphoma kinase (Ki-1) , CD246 antigen , mutant anaplastic lymphoma kinase , anaplastic lymphoma receptor tyrosine kinase , anaplastic lymphoma kinase

GENE ID SPEZIES
11682 Mus musculus
421297 Gallus gallus
238 Homo sapiens
483021 Canis lupus familiaris
100518423 Sus scrofa
536642 Bos taurus
266802 Rattus norvegicus
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