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Partial silencing of RPS14 inhibits the proliferation of SKM-1, an acute myeloid leukemia (zeige BCL11A Proteine) cell line, and RPS14 negatively regulates p53 (zeige TP53 Proteine) activation in SKM-1 cells.
RPS14 stabilized and activated p53 (zeige TP53 Proteine) by inhibiting HDM2-mediated p53 (zeige TP53 Proteine) polyubiquitination and degradation
Patients with nonclassical Diamond Blackfan anemia and other hypoproliferative anemias may have somatically acquired 5q deletions with RPS14 haploinsufficiency
Data indicate that RPS14 negates c-Myc (zeige MYC Proteine) functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA.
lower RPS14 predicts prolonged survival and possible response to lenalidomide in lower risk MDS (zeige PAFAH1B1 Proteine) patients.
RPS14 and RPS19 (zeige RPS19 Proteine) have distinct roles in regulating the MDM2 (zeige MDM2 Proteine)-p53 (zeige TP53 Proteine) feedback loop in response to ribosomal stress
Loss of RPS14 is associated with 5q-syndrome.
Combined loss of miR (zeige MLXIP Proteine)-145 and RPS14 cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome.
Myelodysplactic syndrome patients with an intermediate-1 risk score and low RPS14 expression have a superior median overall survival compared to patients with high RPS14 expression.
p53 (zeige TP53 Proteine) accumulates selectively in the erythroid lineage in primary human hematopoietic progenitor cells after expression of shRNAs targeting RPS14, the ribosomal protein gene deleted in the 5q-syndrome, or RPS19 (zeige RPS19 Proteine).
Rps14 haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8 (zeige S100A8 Proteine)-S100A9 (zeige S100A9 Proteine) expression, leading to a p53 (zeige TP53 Proteine)-dependent erythroid differentiation defect.
ribosomal protein RPS-14 is able to modulate let-7 function in C. elegans
p53 (zeige TP53 Proteine) synthesis is affected in zebrafish tumors with ribosomal protein gene mutations
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants.
40S ribosomal protein S14
, emetine resistance
, 28S ribosomal protein S14, mitochondrial
, mitochondrial 28S ribosomal protein S14
, ribosomal protein S14
, ribosomal protein S14b