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Bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors, and such an activity requires the expression of nitric oxide synthase-2.
Studied iNOS(inducible nitric oxide synthase) activation thru mPGES-1 (microsomal prostaglandin E synthase-1 (zeige PTGES Proteine)) signaling driven by EGFR (EGF receptor (zeige EGFR Proteine)) in cancer progression models.
Higher expression of inducible nitric oxide synthase (NOS2) is associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC).
The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer.
Exploration into the mechanisms of the cGMP-mediated protection identified a role for the iNOS/NO/cGMP pathway in the activation of ADAM17 (TACE (zeige ADAM17 Proteine)), which is a sheddase that cleaves a number of cell surface receptors including TNF (zeige TNF Proteine) receptor type 1 (TNFR1 (zeige TNFRSF1A Proteine)).
results suggest that NOS2 polymorphisms may influence the risk of aggressive prostate cancer and that these polymorphisms could have an impact on disease pathogenesis, possibly by affecting intracellular nitric oxide levels.
no significant difference in frequency of NOS2 (zeige NANOS2 Proteine)-1659C/T polymorphism was observed between patients and controls. None of the studied SNPs were associated with erosive disease, seropositivity or extra-articular manifestations. The -277A/G and -1026 G/T promoter polymorphisms in iNOS may confer susceptibility to rheumatoid arthritis (RA). in South Indian Tamils.
This is the first reported evidence for NO-enhanced bystander aggressiveness in the context of PDT (zeige TWIST1 Proteine). In the clinical setting, such effects could be averted through pharmacologic use of iNOS inhibitors as non-ionizing photodynamic therapy adjuvants
This increase was inhibited in the presence of the nonspecific iNOS inhibitor aminoguanidine (AG).
our study shows that the expression of iNOS is increased in both central airways and the alveolar parenchyma, but not in BAL cells, in uncontrolled asthmatics as compared to controlled asthmatics and healthy controls.
omega-alkynyl arachidonic acid may promote the anti-inflammatory M2 polarization of macrophages in acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1alpha (zeige HIF1A Proteine) and iNOS.
Inducible nitric oxide synthase (NOS2)-deficiency enhanced survival and reduced tumor severity in genetically engineered mouse model of pancreatic cancer (KPC mouse).
These results suggested that Fyn (zeige FYN Proteine) has a regulatory role in iNOS expression in astrocytes during neuroinflammatory responses.
Inducible NO synthase (iNOS) mRNA levels were significantly increased immediately after exposure to hypergravity.
Downregulation of inducible NO synthetase (iNOS) resulted in downregulation of heme oxygenase 1 (HO-1 (zeige HMOX1 Proteine)), and, conversely, upregulation of iNOS enhanced HO-1 (zeige HMOX1 Proteine) activity.
results indicate that in addition to its function in caveolae biogenesis, Cavin-2 (zeige SDPR Proteine) plays a critical role in endothelial cell maintenance and function by regulating eNOS (zeige NOS3 Proteine) activity.
iNOS is not involved in the cardioprotective effects of late-phase remote preconditioning of trauma.
Data (including data from studies using knockout mice) suggest that expression of iNOS mRNA/protein is elevated in liver cytosol/mitochondria in sepsis; these changes are related to enhanced oxidative/nitrosative stress in liver in sepsis; absence of iNOS (but not nNOS (zeige NOS1 Proteine)) prevents impairment of liver mitochondria during sepsis; melatonin/antioxidant treatment prevents liver damage.
PHLPP1 reduced IFN-gamma (zeige IFNG Proteine)-stimulated but not LPS (zeige TLR4 Proteine)-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-gamma-induced (zeige SAMHD1 Proteine) ser (zeige SIGLEC1 Proteine)(727) STAT1 (zeige STAT1 Proteine) phosphorylation and iNOS expression.
The expression of iNOS participates in the pathogenesis of cochlear damage caused by acoustic trauma.
Our data demonstrate that both iNOS and nNOS (zeige NOS1 Proteine) represent sources for nitric oxide overproduction in ileal myenteric plexus during ischemia and reperfusion
Salvia miltiorrhiza injection had no effect on the expression of nNOS (zeige NOS1 Proteine) and eNOS (zeige NOS3 Proteine), but could inhibit iNOS in choclea.
iNOS and AChE expression increases in spiral ganglia treated with streptomycin. Salvia miltiorrhiza injection reduces ototoxicity by reducing the levels of iNOS and AChE.
The auditory brainstem response threshold increases and the expression of iNOS strengthens in streptomycin ototoxicity.
polymorphism of the NOS2 gene may contribute to the susceptibility of Holstein cattle to bovine tuberculosis
Vitamin D receptor (zeige VDR Proteine) activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
The expression, localization, and distribution of 3 nitric oxide synthase enzymes through the estrous cycle in bovien fallopian tubes are reported.
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha (zeige TNF Proteine) and iNOS pathways in the regulation of this pathological condition.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
All infected calves had an increased number of cells expressing iNOS, nitrotyrosine and manganese superoxide dismutase (zeige SOD2 Proteine) in the inflamed lung tissue
iNOS is expressed in ruminant granulosa cells and is regulated by gonadotrophins and oestradiol
Expression level of NOS2 mRNA in endometrial biopsies from cows with puerperal endometritis is high. Highest expression of is found in cows with clinical endometritis.
data suggest that the transcriptional inducible NOS response to octacalcium phosphate crystals involved both the p38 and the JNK MAPK pathways, probably under the control of activator protein-1
The expression of iNOS and NRAMP1 (zeige SLC11A1 Proteine) in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported.
iNOS was shown to be constitutively expressed within porcine LV. Its level decreases during the progression of systolic nonischemic HF in the pig model.
Our results suggest that the presence of low mycotoxin doses in feed slows down the mRNA expression of both nitric oxide synthase isomers, which probably lowers the concentrations of nitric oxide, a common precursor of inflammation.
In swine, IL-8 (zeige IL8 Proteine), TNF-ALPHA (zeige TNF Proteine), INOS AND MIP-1BETA (zeige CCL4 Proteine) were increased during mechanical ventilation in a time-related fashion.
Data suggest that pig sperm contain bNOS (zeige NOS1 Proteine), iNOS, and eNOS (zeige NOS3 Proteine); up-regulation of NOS by leptin (zeige LEP Proteine) during acrosome reaction and inhibition of acrosome reaction by inhibitors of nitric oxide synthases suggests these enzymes are involved in acrosome reaction.
Periodic acceleration (pGz) acutely increases endothelial and neuronal nitric oxide synthase (zeige NOS1 Proteine) expression in endomyocardium of normal swine.
Regional difference in blood flow has no effect on iNOS protein content in different size conduit arteries.
Along with several single loci, the epistatic QTLs, SLC9A3R1 and NOS2 control for total number of piglets born and number of piglets born alive in a F(2) Iberian by Meishan intercross.
expression of inducible nitric-oxide synthase by infected mucosa was without detriment to overall barrier function and may serve to promote clearance of infected enterocytes
In this study, neuronal iNOS expression and increase of NO production were found in the acute phase of hypoxia-ischemia. Brain biopterin did not increase in hypoxia-ischemia although plasma biopterin was five-fold elevated.
Immunoreactivity of eNOS (zeige NOS3 Proteine) was similar to NADPH-d (zeige NQO1 Proteine) staining. Clear iNOS immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.
Kidneys from circulation-restricted fetuses showed increased inducible nitric oxide synthase messenger RNA.
The hypotestosteronemia observed in diabetic rabbits could be a consequence of the increased expression of iNOS and could contribute to the hyperreactivity of the rabbit carotid artery to testosterone.
The result demonstrate that mechanical stress on synovial cells induces gene expressions of iNOS.
In heart failure, increased iNOS and arginase II (zeige ARG2 Proteine) expression results in unchanged NO species and protein S-nitrosylation; with substrate limitation, uncoupled iNOS produces superoxide anions and contributes to contractile dysfunction.
amyloid and oxidative stress-related disease proteins like NOS 2 is increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.
Pulmonary ischaemia-reperfusion up-regulates inducible nitric oxide synthesis and/activity, which coincides with reduced endothelial nitric oxide synthase (zeige NOS3 Proteine) activity.
Data suggest distinct localizations of iNOS along the radial arteries and eNOS (zeige NOS3 Proteine) at the spiral arteries/arterial sinuses in the developing placenta.
Ulinastatin (zeige AMBP Proteine) effectively inhibited the increased expression of MMP-2 (zeige MMP2 Proteine), MMP-3 (zeige MMP3 Proteine), and iNOS in degenerated NP cells induced by IL-1beta (zeige IL1B Proteine) in vitro.
We demonstrated that NOS family genes are expressed in caprine peripheral blood mononuclear cells and higher expression of these genes with HSPs during thermal stress suggest possible involvement of them to ameliorate deleterious effect of thermal stress so as to maintain cellular integrity and homeostasis in goats
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
NOS type II
, NOS, type II
, hepatocyte NOS
, inducible NO synthase
, inducible NOS
, nitric oxide synthase 2A (inducible, hepatocytes)
, nitric oxide synthase, inducible
, nitric oxide synthase, macrophage
, peptidyl-cysteine S-nitrosylase NOS2
, inducible nitric oxide synthase
, macrophage NOS
, nitric oxide synthase 2, inducible, macrophage
, nitric oxide synthase 2, inducible
, nitric oxide synthase 2A
, nitric oxide synthase-like protein
, nitric-oxide synthase like protein
, nanos homolog 2