EZH2 Proteine (EZH2)

Bezeichnung:
Enhancer of Zeste Homolog 2 (Drosophila) Proteine (EZH2)
Auf www.antikoerper-online.de finden Sie aktuell 8 Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen EZH2 Antikörper (233) und EZH2 Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 275 EZH2 Produkte verfügbar.
Synonyme:
Enx-1, ENX1, Enx1h, eya2, EZH1, ezh2, EZH2b, im:7149338, KMT6, KMT6A, mKIAA4065, olezh2, WVS, WVS2, xez, zgc:136376, zgc:152758
alle Proteine anzeigen Gen GeneID UniProt
EZH2 2146 Q15910
EZH2 14056 Q61188
Ratte EZH2 EZH2 312299  

Weitere Synonyme anzeigen

EZH2 Proteine (EZH2) nach Spezies

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Am meisten referenzierte EZH2 Proteine

  1. Human EZH2 Protein expressed in HEK-293 Cells - ABIN2720645 : Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015 (PubMed)
    Zeige alle 2 Referenzen für 2720645

  2. Human EZH2 Protein expressed in Wheat germ - ABIN1353283 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

Weitere Proteine zu EZH2 Interaktionspartnern

Xenopus laevis Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Interaktionspartner

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.

Human Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Interaktionspartner

  1. that EZH2 is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.

  2. EZH2 mutations were mostly early events in leukemogenesis and showed a complex mutational hierarchy

  3. The EZH2 was recruited to the IRF8 (zeige IRF8 Proteine) promoter after RANKL (zeige TNFSF11 Proteine) stimulation to deposit the negative histone mark H3K27me3 and downregulate IRF8 (zeige IRF8 Proteine) expression.

  4. Authors demonstrate that inhibition of the non-canonical NF-kB pathway by targeting NF-kB2/p52 or the upstream kinase NIK restores the senescence program in melanoma cells through the decrease of EZH2.

  5. The data suggest that EZH2-H3K27me3 regulatory mechanism dynamically changes the expression levels of DNA mismatch repair gene MutS homolog 2 (zeige MSH2 Proteine), through epigenetic mark H3K27me3.

  6. TRIM28 (zeige TRIM28 Proteine) depletion repressed EZH2 recruitment to chromatin and expression of this gene set, in parallel with decreased CD44 (zeige CD44 Proteine)(hi)/CD24 (zeige CD24 Proteine)(lo) mammosphere formation.

  7. EZH2 overexpression is significantly associated with inferior outcome in patients with primary gastrointestinal diffuse large B-cell lymphoma.

  8. High EZH2 expression is associated with liver neoplasms.

  9. EZH2 not only acts through the direct regulation of signaling modules and lineage-specific transcription factors but also targets many novel genes important for mediating mesenchymal stem cell osteogenic differentiation.

  10. EZH2 expression was associated with survival in patients with colorectal cancer who were treated with anti-EGFR (zeige EGFR Proteine) therapeutics. Moreover, low EZH2 expression was independently associated with shorter progression-free survival in patients with cancer, suggesting that EZH2 expression is a useful additional prognostic biomarker for anti-EGFR (zeige EGFR Proteine) therapy.

Mouse (Murine) Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Interaktionspartner

  1. results uncover a crucial role for EZH2 in adaptive lymphocytes to control the developmental timing of effectors of the pre-Ag receptor checkpoints

  2. These findings identify the Ezh2-Hsp90 (zeige HSP90 Proteine) interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease.

  3. Eed (zeige EED Proteine) and Ezh2 have distinct roles in urothelial differentiation

  4. Findings uncover an Ezh2-dependent mechanism to restrict the smooth muscle gene expression program in the developing mesothelium and allow appropriate cell fate decisions to occur in this multipotent mesoderm lineage.

  5. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (zeige E2F1 Proteine) to recruit EZH2 to diverse repeat sequences.

  6. This study identified Ezh2 as enriched in melanoma cancer stem cells (MCS (zeige SMCP Proteine) cells) and showed that Ezh2 knockdown or treatment with small molecule Ezh2 inhibitors reduces MCS (zeige SMCP Proteine) cell spheroid formation, survival, invasion and migration.

  7. Ezh2-/- deletion resulted in skeletal deformities, increased osteoclastogenic potential and upregulation of Rankl (zeige TNFSF11 Proteine) and M-csf (zeige CSF1R Proteine) expression by mesenchymal stem cells.

  8. These findings indicate Ezh2/PRC2 plays crucial roles in regulating neurogenesis from both cerebellar germinal zones.

  9. our results revealed a novel mechanism in which EZH2 stability is regulated by SKP2 through the TRAF6 (zeige TRAF6 Proteine)-mediated and K63-linked ubiquitination, which contributes to elevated levels of H3K27me3 during prostate tumorigenesis and CRPC growth.

  10. N-Myc (zeige MYCN Proteine) Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer and redirects EZH2 activity and sensitizes cells to EZH2 inhibitors.

EZH2 Protein Überblick

Protein Überblick

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EZH2

  • enhancer of zeste homolog 2 (Drosophila) (EZH2)
  • enhancer of zeste homolog 2 (ezh2)
  • enhancer of zeste homolog 2 (ezh2-a)
  • enhancer of zeste homolog 2 (Drosophila) (Ezh2)
  • enhancer of zeste homolog 2 (Drosophila) (ezh2)
  • Enx-1 Protein
  • ENX1 Protein
  • Enx1h Protein
  • eya2 Protein
  • EZH1 Protein
  • ezh2 Protein
  • EZH2b Protein
  • im:7149338 Protein
  • KMT6 Protein
  • KMT6A Protein
  • mKIAA4065 Protein
  • olezh2 Protein
  • WVS Protein
  • WVS2 Protein
  • xez Protein
  • zgc:136376 Protein
  • zgc:152758 Protein

Bezeichner auf Proteinebene für EZH2

enhancer of zeste 2 , enhancer of zeste homolog 2 (Drosophila) , Polycomb protein EZH2 , histone-lysine N-methyltransferase EZH2 , histone-lysine N-methyltransferase EZH2-like , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , lysine N-methyltransferase 6 , enhancer of zeste homolog 2 , eyes absent homolog 2

GENE ID SPEZIES
745437 Pan troglodytes
100051290 Equus caballus
550047 Xenopus (Silurana) tropicalis
709075 Macaca mulatta
100125823 Oryzias latipes
100394758 Callithrix jacchus
100447447 Pongo abelii
100540374 Meleagris gallopavo
100580962 Nomascus leucogenys
399174 Xenopus laevis
2146 Homo sapiens
14056 Mus musculus
420784 Gallus gallus
475511 Canis lupus familiaris
100625497 Sus scrofa
509106 Bos taurus
312299 Rattus norvegicus
768133 Danio rerio
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