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Placental lactogen is expressed but is not translated into protein in breast cancer.
These results indicate that placental lactogen induces CYP2E1 (zeige CYP2E1 Proteine) expression via PI3-kinase (zeige PIK3CA Proteine) pathway in human hepatocytes.
Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta.
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
Data conclude that members of the C/EBP (zeige CEBPA Proteine) and Ets (zeige ETS1 Proteine) families can differentially modulate CS-Benh and CS-Aenh activity.
hPL (zeige LGALS1 Proteine)-A is involved in the regulation of pancreatic beta cells activity.
Results strongly support a conformationally mediated obligate-ordered prolactin receptor (zeige PRLR Proteine) binding for each of the three lactogenic hormones: prolactin (zeige PRL Proteine), growth hormone (zeige GH1 Proteine), and placental lactogen.
The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth.
Investigation of the GRB2 (zeige GRB2 Proteine), GRB7 (zeige GRB7 Proteine), and CSH1 genes as candidates for the Silver-Russell syndrome (SRS (zeige SMS Proteine)) on chromosome 17q.
a role for CSH1 haploinsufficiency in the etiology of growth retardation
Dysregulation of PL and leptin (zeige LEP Proteine) in nuclear transfer placentomes could affect cell migration and invasion and subsequently placental metabolism and transfer of nutrients to fetus, leading to increased placental and fetal macrosomia.
Serum free culture conditions significantly enhanced Cyp17 (zeige CYP17A1 Proteine) and Csh1 (zeige PRL3D1 Proteine) but not Hsd3b (zeige HSD3B1 Proteine) expression in trophoblast.
This is the first report to identify the differential regulatory mechanisms of the bCSH1 and bPRP1 genes and indicates that bCSH1 might potentially be the only transcript that is subject to DNA methyltransferase (zeige DNMT1 Proteine) regulation.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
, chorionic somatomammotropin A
, chorionic somatomammotropin hormone
, placental lactogen