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TACR1 Proteine (TACR1)

Bezeichnung:
Tachykinin Receptor 1 Proteine (TACR1)
Auf www.antikoerper-online.de finden Sie aktuell 11 Tachykinin Receptor 1 (TACR1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TACR1 Antikörper (151) und TACR1 Kits (43) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 211 TACR1 Produkte verfügbar.
Synonyme:
ASPR, nk1R, NKIR, Spr, Tac1r, Tacr1
alle Proteine anzeigen Gen GeneID UniProt
TACR1 6869 P25103
TACR1 21336 P30548
Ratte TACR1 TACR1 24807 P14600

Weitere Synonyme anzeigen

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Am meisten referenzierte TACR1 Proteine

  1. Human TACR1 Protein expressed in Escherichia coli (E. coli) - ABIN1047692 : Takeda, Chou, Takeda, Sachais, Krause: Molecular cloning, structural characterization and functional expression of the human substance P receptor. in Biochemical and biophysical research communications 1991 (PubMed)
    Zeige alle 2 Referenzen für ABIN1047692

Weitere Proteine zu TACR1 Interaktionspartnern

Human Tachykinin Receptor 1 (TACR1) Interaktionspartner

  1. Expression substance P/neurokinin A (zeige TAC1 Proteine)/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 (zeige TAC1 Proteine) receptors are dysregulated in uterine leiomyomata.

  2. results suggest that ARRB1 (zeige ARRB1 Proteine) plays an essential role in NK1R-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1 (zeige ARRB1 Proteine)-mediated signaling via NK1R may have potential significance for therapeutic strategies targeting glioblastoma.

  3. Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P (zeige TAC1 Proteine) exhibits fast association kinetics; neurokinin A (zeige TAC1 Proteine) exhibits slow association kinetics.

  4. We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS (zeige ROS1 Proteine) production in cardiomyocytes

  5. These findings reveal important insight into the molecular mechanisms of the NK1R complex as a critical component in a model of pediatric liver cancer and may support the development of novel therapeutic interventions for hepatoblastoma

  6. Neuropeptide signaling through neurokinin-1 (zeige TAC1 Proteine) and neurokinin-2 (zeige TAC1 Proteine) receptors augments antigen presentation by human dendritic cells

  7. Inhibition of CaV2.3 (zeige CACNA1E Proteine) channels by NK1 (zeige CD160 Proteine) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (zeige CAV1 Proteine).

  8. NK-1 (zeige CD160 Proteine) activation could enhance EGFR (zeige EGFR Proteine) expression and phosphorylation, and then activate EGFR (zeige EGFR Proteine) related Erk/MAPK (zeige MAPK1 Proteine) and Akt (zeige AKT1 Proteine) pathway.

  9. The single nucleotide polymorphisms in the TACR1 gene are associated with sex differences in postoperative nausea and vomiting.

  10. Results show the existence of a relevant alteration in NK-1R expression in bipolar disorder patients and further suggest Substance P (zeige TAC1 Proteine) involvement in BD.

Mouse (Murine) Tachykinin Receptor 1 (TACR1) Interaktionspartner

  1. the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.

  2. NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test

  3. NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch.

  4. The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE (zeige ACE Proteine) inhibitors could provide a novel treatment for this disorder.

  5. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P (zeige TAC1 Proteine) to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS (zeige NOS1 Proteine) and the NK-1R

  6. the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R

  7. Substance P (zeige TAC1 Proteine) partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 (zeige CYBB Proteine) axis-mediated pathway.

  8. NK1 (zeige HGF Proteine)-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection.

  9. The behavioural response of mice lacking NK1r to guanfacine resembles its clinical profile in treatment of ADHD

  10. Together, our findings revealed a critical role of microglial NOX2 (zeige CYBB Proteine) in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD.

Rabbit Tachykinin Receptor 1 (TACR1) Interaktionspartner

  1. Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R and VIPR1 (zeige VIPR1 Proteine).

Guinea Pig Tachykinin Receptor 1 (TACR1) Interaktionspartner

  1. Activation of neurokinin-1 (zeige TAC1 Proteine) receptors in primary sensory neurons plays a role in the generation of overactive bladder.

  2. Substance P (zeige TAC1 Proteine) and SP-R mRNA expressions were reduced after IMETIT treatment of allergic rhinitis.

TACR1 Protein Überblick

Protein Überblick

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.

Alternative names and synonyms associated with TACR1

  • substance-P receptor-like (LOC100053491)
  • tachykinin receptor 1 (TACR1)
  • tachykinin receptor 1 (Tacr1)
  • ASPR Protein
  • nk1R Protein
  • NKIR Protein
  • Spr Protein
  • Tac1r Protein
  • Tacr1 Protein

Bezeichner auf Proteinebene für Tachykinin Receptor 1 Proteine (TACR1)

NK-1 receptor , NK-1R , substance-P receptor , tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) , Nk1 receptor , neurokinin receptor 1 , substance P receptor , SPR , neurokinin 1 receptor , substance p receptor , neurokinin receptor subtype NK1 , tachikinin receptor 1 , tachykinin receptor 1 , neurokinin-1 receptor

GENE ID SPEZIES
100053491 Equus caballus
6869 Homo sapiens
21336 Mus musculus
24807 Rattus norvegicus
403815 Canis lupus familiaris
407133 Bos taurus
100357296 Oryctolagus cuniculus
100135626 Cavia porcellus
395677 Gallus gallus
101122011 Ovis aries
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