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Kinase activation led to increased MMP-2 (zeige MMP2 Proteine) and MT1-MMP (zeige MMP14 Proteine) expression and melanoma cell migration induced by hHK-1 (zeige HOOK1 Proteine). Thus, hHK-1 (zeige HOOK1 Proteine) and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target
Within a small cohort of patients who presented for treatment,a novel gene was identified that appears to contribute to anorexia nervosa pathophysiology, TACR1.
NK1 receptor expression is increased in colonic tissues from experimental colitis models and in the colon of Irritable Bowel Disease patients.
High Truncated Neurokinin-1 Receptor expression is associated with Neuroblastoma (zeige ARHGEF16 Proteine).
Abnormalities in substance P neurokinin-1 (zeige TAC1 Proteine) receptor binding in key brainstem nuclei is associated with sudden infant death syndrome.
TGF-beta1 (zeige TGFB1 Proteine) down-regulates the gene expression of the full-length variant of NK-1 (zeige CD160 Proteine) R in human keratocytes, which might impact its signaling pathway and thus explain the known delay in internalization after activation by SP seen with TGF-beta1 (zeige TGFB1 Proteine) treatment.
Expression substance P/neurokinin A (zeige TAC1 Proteine)/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 (zeige TAC1 Proteine) receptors are dysregulated in uterine leiomyomata.
results suggest that ARRB1 (zeige ARRB1 Proteine) plays an essential role in NK1R-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1 (zeige ARRB1 Proteine)-mediated signaling via NK1R may have potential significance for therapeutic strategies targeting glioblastoma.
Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P (zeige TAC1 Proteine) exhibits fast association kinetics; neurokinin A (zeige TAC1 Proteine) exhibits slow association kinetics.
We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS (zeige ROS1 Proteine) production in cardiomyocytes
results indicate the contribution of NK1R signaling in maintaining the homeostasis of the ocular surface under steady-state condition, and that the lack of functional NK1R increases the susceptibility of eyes to develop severe herpes stromal keratitis upon ocular HSV-1 infection
the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.
NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test
NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch.
The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE (zeige ACE Proteine) inhibitors could provide a novel treatment for this disorder.
Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P (zeige TAC1 Proteine) to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS (zeige NOS1 Proteine) and the NK-1R
the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R
Substance P (zeige TAC1 Proteine) partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 (zeige CYBB Proteine) axis-mediated pathway.
NK1 (zeige HGF Proteine)-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection.
The behavioural response of mice lacking NK1r to guanfacine resembles its clinical profile in treatment of ADHD
Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R and VIPR1 (zeige VIPR1 Proteine).
Activation of neurokinin-1 (zeige TAC1 Proteine) receptors in primary sensory neurons plays a role in the generation of overactive bladder.
Substance P (zeige TAC1 Proteine) and SP-R mRNA expressions were reduced after IMETIT treatment of allergic rhinitis.
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
, substance-P receptor
, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
, Nk1 receptor
, neurokinin receptor 1
, substance P receptor
, neurokinin 1 receptor
, substance p receptor
, neurokinin receptor subtype NK1
, tachikinin receptor 1
, tachykinin receptor 1
, neurokinin-1 receptor