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Results suggest that sequence variants in TNC and COL5A1 genes are associated with superficial digital flexor tendinopathy in TB racehorses. In
Tenascin-C protein expression in this muscle was confined to arterioles and venules (80% of cases) and increased after training in A-allele carriers. Prior to training, volume densities of subsarcolemmal and myofibrillar mitochondria in m. vastus lateralis muscle were 49% and 18%, respectively, higher in A/A homozygotes relative to T-nucleotide carriers (A/T and T/T)
Study that recombinant TNC consisting of the epidermal growth factor (EGF (zeige EGF Proteine)-like repeats induced cerebral arterial constriction via EGF receptor (zeige EGFR Proteine) and activation of ERK1/2
Tenascin-C was abundant in cortical white and gray matter in brain tissue from Alzheimer's Disease patients.
Overexpression of TNC, SMA (zeige SMN1 Proteine), and vimentin (zeige VIM Proteine) were significantly correlated with the lower overall survival in prostate cancer patients.
Gain- and loss-of-function xenograft manipulations demonstrated that a mutant IDH1 (zeige IDH1 Proteine) restricts glioma aggression by reducing HIF1alpha (zeige HIF1A Proteine)-dependent TNC expression to decrease extracellular matrix stiffness and mechanosignalling.
analysis of SNPs in tenascin-C (TNC) associated with degenerative rotator cuff tears
High TNC expression is associated with retinoblastoma.
prepartum and postpartum TN-C serum levels significantly higher in mild and severe preeclampsia than in healthy pregnancy
Tenascin-C overexpression in cancer cells and stromal fibroblasts was an independent poor prognostic factor for overall survival and disease-free survival esophageal squamous cell carcinoma patients.
Serum TNC levels are significantly raised and correlate with various clinical and laboratory variables of disease activity in children with enthesitis-related arthritis
Study suggests that tenascin-C (TnC) contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and matrix metalloproteinase 9 (zeige MMP9 Proteine) are likely to be important for these processes to occur.
the exact role of TNC in primary tumor growth
A deficiency of tenascin C interferes with Th1 (zeige HAND1 Proteine) and Th17 cells, protecting animals from experimental autoimmune encephalomyelitis.
Tenascin-C may be an important mediator in the development of brain edema and blood-brain barrier disruption following subarachnoid hemorrhage, mechanisms for which may involve MAPK (zeige MAPK1 Proteine)-mediated MMP-9 (zeige MMP9 Proteine) induction and ZO-1 (zeige TJP1 Proteine) degradation
TN-C aggravates autoimmune myocarditis by driving the dendritic cell activation and Th17 differentiation via toll-like receptor 4 (zeige TLR4 Proteine).
TNC supports the stress-induced expression of extracellular matrix that reinforce the aorta and the stress-induced excessive inflammatory response in the aorta.
TNC plays an important role in TMJ wound healing, especially for wounds generated by mechanical stress.
Tenascin-C is required for normal Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling in the whisker follicle stem cell niche.
TNC downregulates Dickkopf-1 (DKK1 (zeige DKK1 Proteine)) promoter activity through the blocking of actin stress fiber formation, activates Wnt (zeige WNT2 Proteine) signaling, and induces Wnt (zeige WNT2 Proteine) target genes in tumor and endothelial cells.
The increased levels of elastin (zeige ELN Proteine), type V collagen and tenascin C are probably the result of increased expression by fibroblastic cells; reversely, elastin (zeige ELN Proteine) influences myofibroblast differentiation
TNC does not appear to contribute directly to outflow resistance in the eye.
TNC could be a potential candidate gene for meat quality traits in pigs.
tenascin binds to fibronectin (zeige FN1 Proteine) at a cryptic binding site
Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers. Increase of rat soleus muscle loading modifies basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C.
tenascin-C is part of a specialized extracellular matrix in the region of the horizontal myoseptum that influences the growth of motor axons
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
, tenascin C (hexabrachion)
, GP 150-225
, glioma-associated-extracellular matrix antigen
, hexabrachion (tenascin)
, myotendinous antigen
, tenascin-C isoform 14/AD1/16