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Neu2 from thymus exhibited sialidase activity with fetuin (zeige AHSG Proteine) at pH 7.0.
Our data demonstrate that IGF-1 (zeige IGF1 Proteine)-induced myoblast differentiation and hypertrophy are driven, at least in part, by Neu2 upregulation and further support the significant role of cytosolic sialidase in myoblasts.
the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene
30-40% of B and C forms of Neu2 activity was located in the crude membrane-fraction, and hydrolyzed ganglioside effectively, while both soluble fraction showed particular behavior with substrate specificity.
cytosolic GBA3 (zeige GBA3 Proteine) is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein
Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations.
Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis.
the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 (zeige PCSK1 Proteine) prostate cancer cells.
NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine.
the first high resolution x-ray structures of sialidase, human Neu2
Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells.
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.
sialidase 2 (cytosolic sialidase)
, N-acetyl-alpha-neuraminidase 2
, brain sialidase
, cystolic sialidase
, cytosolic sialidase
, murine thymic sialidase
, skeletal muscle sialidase
, neuraminidase 2