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Pitx2c expression is rea (zeige PITX2 ELISA Kits)ctivated, while expression of Myf5 is downregulated in human systolic heart failure as determined by qRT-PCR and Western blot analyses.
results are the first demonstration of a myogenic conversion of human mesenchymal and endothelial cells by Myf5
DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy
The myogenic basic helix-loop-helix family of transcription factors, MyoD (zeige MYOD1 ELISA Kits), Myf5, myogenin (zeige MYOG ELISA Kits), and MRF4 (zeige MYF6 ELISA Kits), can each activate the muscle differentiation program.
Mrf4 (zeige MYF6 ELISA Kits) expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis
Myogenin (zeige MYOG ELISA Kits) and myogenic differentiation factor D (MyoD (zeige MYOD1 ELISA Kits)) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (zeige MYOG ELISA Kits) (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 (zeige MYF6 ELISA Kits) protein increased (P < 0.05) in both young and old.
A novel homozygous polymorphism that prevented the binding of MYF-5 to FOXE1 (zeige FOXE1 ELISA Kits) promoter and affected the FOXE1 (zeige FOXE1 ELISA Kits) expression was found in 45% nonsyndromic cleft palate.
Novel RNA-binding activity of MYF5 enhances Ccnd1 (zeige CCND1 ELISA Kits) mRNA translation during myogenesis.
Transcription of the skeletal muscle program is achieved by the expression of MyoD (zeige MYOD1 ELISA Kits), which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites
The Myf5- and Myogenin (zeige MYOG ELISA Kits)-deficient mice showed a partial or complete, respectively, loss of TMC (zeige STT3A ELISA Kits) in an otherwise regularly structured thymus.
Elimination of Myf5(Cre)-DTA cells on a Myod (zeige MYOD1 ELISA Kits) null background did not result in the total absence of skeletal muscles
A muscle-specific (zeige EIF3K ELISA Kits) regulatory element of p57(kip2 (zeige CDKN1C ELISA Kits)) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch (zeige NOTCH1 ELISA Kits) targets Hes1/Hey1 (zeige HEY1 ELISA Kits) in progenitor cells, is identified.
lineage tracing based on multiple reporter lines has demonstrated that regardless of common ancestral expression of Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages
The results demonstrate the heterogeneity and functional differences of the Myf5- and non-Myf5-lineage cells in the white adipose tissue.
Adult satellite cells derive from progenitors that first express the myogenic determination gene Myf5 during fetal stages of myogenesis.
Direct molecular regulation of the myogenic determination gene Myf5 by Pax3 (zeige PAX3 ELISA Kits), with modulation by Six1 (zeige SIX1 ELISA Kits)/4 factors, is exemplified by the -111 kb-Myf5 enhancer
The observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5 haploinsufficiency.
Loss of Myf5 function results in a cascade effect that begins with abnormal formation of the dorsal organizer during gastrulation, causing defects in myf5-knockdown embryos
the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protein level of phosphorylated p38a (zeige MAPK14 ELISA Kits) and activates myf5 promoter activity of zebrafish embryos during myogenesis.
a novel intronic microRNA, miR (zeige MYLIP ELISA Kits)-In300, which is derived from I300 of the first intron of zebrafish myf5, enables significant repression of myf5 promoter activity through silencing the long isoform of the Dickkopfs-3 gene.
A novel regulatory base sequence functions as a key element to drive the somite-specificity of myf-5.
Functional analysis of intron 1 showed a strong, negative, cis (zeige CISH ELISA Kits)-regulatory element located at +502/+835, and this is the first study to identify a novel, cis (zeige CISH ELISA Kits)-acting silencer that is crucial to negatively regulating myf-5 expression.
Foxd3 (zeige FOXD3 ELISA Kits), a well-known regulator in neural crest development, is also involved in myf5 regulation
Myf5 and Myod (zeige MYOD1 ELISA Kits) function independently during cranial myogenesis.
cell lineage-specific expression of myf5 is delicately orchestrated by multiple modules within the distal upstream region. This study provides an insight to understand the molecular control of myf5 and myogenesis in the zebrafish.
The effects of myostatin (zeige MSTN ELISA Kits) and myogenic factor 5 polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
Bos taurus MYF5 activates MYF5 and MYOD1 (zeige MYOD1 ELISA Kits) expression in cultured fibroblasts.
A polymorphism showed an influence on Myf5 gene expression in the longissimus dorsi muscle
results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles
myf5 upregulation can be a good criterion for the activation of adult myogenesis during X. laevis metamorphosis
During early Xenopus development Myf5 protein regulates a distinct myogenic program.
FGF8 (zeige FGF8 ELISA Kits), Wnt8 (zeige WNT8A ELISA Kits) and Myf5 are target genes of Tbx6 (zeige TBX6 ELISA Kits) during anteroposterior specification in Xenopus embryo
Exons and promoters are amplified and sequenced in the 5'UTR (zeige UTS2R ELISA Kits) region of this gene.
the novel SNP of the MYF5 gene within exon 1 is valuable for pig breeding.
The expression of Pitx2c (zeige PITX2 ELISA Kits), physiologically downregulated in the postnatal heart, is significantly re-activated in left ventricular failing myocardium which is associated with increased expression of a restrictive set of Pitx2 (zeige PITX2 ELISA Kits) target genes such as myf5.
Of the eight adult pig tissue types that were tested, the expression of Myf5 and MyoD1 (zeige MYOD1 ELISA Kits) was highest in the muscle tissue.
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
class C basic helix-loop-helix protein 2
, myogenic regulatory factor MYF-5
, myogenic regulatory factor 5
, Myf5 homolog
, myogenic factor 5
, MyoD family
, myogenic factor-5
, basic helix-loop-helix nuclear protein
, myogenic factor Xmyf-5