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Human HOPX Protein expressed in Escherichia coli (E. coli) - ABIN1686718
Flom, Behal, Rosen, Cole, Johnson: Definition of the minimal fragments of Sti1 required for dimerization, interaction with Hsp70 and Hsp90 and in vivo functions. in The Biochemical journal 2007
Show all 5 Pubmed References
HOPX has a role in the pathogenesis of skin cancers and skin diseases.
these data indicate that the disruption of the PrP(C (zeige PRNP Proteine))-HOP (zeige STIP1 Proteine) complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC (zeige CALR Proteine)).
HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer.
Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis.
The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene.
Data show that binding of heat shock proteins Hsp70 (zeige HSP70 Proteine) and Hsp90 (zeige HSP90 Proteine) requires prior binding of Hop (zeige STIP1 Proteine) protein to Hsp90 (zeige HSP90 Proteine).
HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer.
GATA6 (zeige GATA6 Proteine) and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC (zeige ADC Proteine) subtype.
HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC (zeige CALR Proteine) progression.
Knockdown of Hop (zeige STIP1 Proteine) caused a decrease in the level of RhoC GTPase (zeige RHOC Proteine), and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop (zeige STIP1 Proteine) regulates directional cell migration by multiple unknown mechanisms.
Analysis of the hematopoietic stem/progenitor cell pool in Hopx-/- mice demonstrated significantly reduced cell frequencies and impaired engraftment in competitive repopulation assays, thus providing functional validation of this positional candidate gene
Type I alveolar cells expressing Hopx manifest plasticity to regenerate type II alveolar cells in the lung.
Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 (zeige IL2 Proteine) Expression.
Hopx integrates Bmp and Wnt (zeige WNT2 Proteine) signaling by physically interacting with activated Smads and repressing Wnt (zeige WNT2 Proteine) genes.
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure.
Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas (zeige FAS Proteine)-induced apoptosis.
Hopx is required for the function of regulatory T cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo.
Hdac2 (zeige HDAC2 Proteine), Hopx, and Gata4 (zeige GATA4 Proteine) coordinately regulate cardiac myocyte proliferation during embryonic development.
data show that Hop (zeige STIP1 Proteine) can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC (zeige HDAC1 Proteine)) activity and can form a complex that includes HDAC2 (zeige HDAC2 Proteine)
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene.
, homeodomain-only protein
, Homeodomain-only protein
, lung cancer-associated Y protein
, not expressed in choriocarcinoma clone 1
, not expressed in choriocarcinoma protein 1
, odd homeobox 1 protein
, odd homeobox protein 1
, homeobox only domain
, homeobox-only protein
, homeodomain only protein
, odd homeobox 1
, global ischemia induced protein GIIG15B
, global ischemia-induced gene 15B protein
, global ischemia-induced protein 15B