FMR1 Proteine (FMR1)

Auf finden Sie aktuell 7 Fragile X Mental Retardation 1 (FMR1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FMR1 Antikörper (173) und FMR1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 192 FMR1 Produkte verfügbar.
AT24755, BcDNA:GM08679, cg6203, dfmr, dfmr1, dFmrp, dfxr, dfxr1, dFXRP, Dmel\\CG6203, dmfr1, EP(3)3517, fmr, Fmr-1, fmr1, Fmrp, FRAXA, FXR, POF, POF1, zFMR1
alle Proteine anzeigen Gen GeneID UniProt
FMR1 2332 Q06787
FMR1 24948 Q80WE1
FMR1 14265  

FMR1 Proteine (FMR1) nach Spezies

Weitere Proteine zu FMR1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) Interaktionspartner

  1. Fmr1 protein associates with ninaE mRNA and represses its translation.

  2. Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 (zeige PQBP1 Proteine) c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients

  3. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  4. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  5. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (zeige TARDBP Proteine) overexpression

  6. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (zeige LSM14A Proteine) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  7. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  8. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  9. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (zeige H2AFV Proteine).

  10. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

Human Fragile X Mental Retardation 1 (FMR1) Interaktionspartner

  1. Fmr1 knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP, the reader protein Brd4 (zeige BRD4 Proteine), appears to be significantly involved in this transcriptional disruption.

  2. The study establishes a functional/physical partnership between FMRP and TDP-43 (zeige TARDBP Proteine) that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.

  3. High CGG trinucleotide repeat expansion in FMR1 gene is associated with fragile X syndrome.

  4. showing the potential of being applicable to other psychiatric disorders to identify endophenotype-specific responses relevant to neurobiology.-Napoli, E., Song, G., Schneider, A., Hagerman, R., Eldeeb, M. A. A. A., Azarang, A., Tassone, F., Giulivi, C. Warburg effect linked to cognitive-executive deficits in FMR1 premutation

  5. Data show that EZH2 (zeige EZH2 Proteine) plays a critical role in the FMR1 gene silencing process and that its inhibition can prolong expression of the FMR1 gene even in the presence of its transcript.

  6. Intragenic FMR1 variants, although much less frequent than CGG expansions, are a significant mutational mechanism leading to FXS.

  7. FMR1 triple CGG repeats in the normal range may be associated with primary ovarian insufficiency in China

  8. Expression of FMRpolyG is pathogenic, while the sole expression of CGG RNA is not. FMRpolyG interacts with the nuclear lamina protein LAP2beta (zeige TMPO Proteine) and disorganizes the nuclear lamina architecture in neurons differentiated from FXTAS iPS (zeige SLC27A4 Proteine) cells. Finally, expression of LAP2beta (zeige TMPO Proteine) rescues neuronal death induced by FMRpolyG.

  9. FMR1 CGG trinucleotide repeats were low in Caucasian women with diminished ovarian reserve.

  10. For routine screening of patients/carriers with full/pre-mutations of the FMR1 gene in the population.

Zebrafish Fragile X Mental Retardation 1 (FMR1) Interaktionspartner

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (zeige ADAR Proteine) genes and Adar2 (zeige ADARB1 Proteine) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) Interaktionspartner

  1. Fmr1-KO mice show significantly less daily movement during the dark cycle and more bouts of activity during the light cycle compared with wild types.

  2. these findings support the notion of FMRP differential neuronal regulation and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to fragile X syndrome pathology

  3. In Fmr1 KO neurons, Mdm2 (zeige MDM2 Proteine) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Proteine) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Proteine) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 KO. Expression of a dephosphomimetic of Mdm2 (zeige MDM2 Proteine) rescues PSD-95 (zeige DLG4 Proteine) ubiquitination, degradation and synapse elimination in Fmr1 KO neurons.

  4. We show here that in mouse models PFC (zeige CFP Proteine) dysfunction in Fragile X Syndrome (FX) can be attributed to the continued absence of FMRP from the PFC (zeige CFP Proteine), independent of FMRP status during development.

  5. Loss of the Fragile X mental retardation protein (zeige NUFIP2 Proteine) leads to excessive excitatory compared with inhibitory inputs in neurons extracting information about sound levels. Functionally, this elevated excitation results in increased firing rates, and abnormal coding of frequency and binaural sound localization cues. Imbalanced early-stage sound level processing could partially explain the auditory processing deficits in FXS.

  6. The results of this study suggest dysregulated NMDARs in the pathophysiology of FXS leading to altered mGluR (zeige GRM8 Proteine)-mediated Long-Term Depression.

  7. FMRP mediates structural plasticity of olfactory bulb adult-born neurons to support olfactory learning through alphaCaMKII local translation.

  8. This study demonstrated that astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS.

  9. FMRP is involved in pri-miRNA processing via enhancing DROSHA (zeige DROSHA Proteine) expression that may play an important role in fragile X syndrome.

  10. FMRP is likely to participate in retinal physiology, since its expression changes with light exposure. In addition, the expression pattern and regulation by light of FMRP seems well conserved since it was similar in both mouse and chick.

FMR1 Protein Überblick

Protein Überblick

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Alternative names and synonyms associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1)
  • fragile X mental retardation 1 (FMR1)
  • fragile X mental retardation 1 (Fmr1)
  • fragile X mental retardation 1 (fmr1)
  • fragile X mental retardation syndrome 1 (Fmr1)
  • AT24755 Protein
  • BcDNA:GM08679 Protein
  • cg6203 Protein
  • dfmr Protein
  • dfmr1 Protein
  • dFmrp Protein
  • dfxr Protein
  • dfxr1 Protein
  • dFXRP Protein
  • Dmel\\CG6203 Protein
  • dmfr1 Protein
  • EP(3)3517 Protein
  • fmr Protein
  • Fmr-1 Protein
  • fmr1 Protein
  • Fmrp Protein
  • FRAXA Protein
  • FXR Protein
  • POF Protein
  • POF1 Protein
  • zFMR1 Protein

Bezeichner auf Proteinebene für FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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