anti-Discs, Large Homolog 4 (Drosophila) (DLG4) Antikörper

Bezeichnung:
anti-Discs, Large Homolog 4 (Drosophila) Antikörper (DLG4)
Auf www.antikoerper-online.de finden Sie aktuell 241 Discs, Large Homolog 4 (Drosophila) (DLG4) Antikörper von 27 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Discs, Large Homolog 4 (Drosophila) Kits (16) und Discs, Large Homolog 4 (Drosophila) Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 272 Discs, Large Homolog 4 (Drosophila) Produkte verfügbar.
Synonyme:
11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, dlg-1, dlg-A, Dlg1, DLG4, dlgA, Dlgh4, dlgS97, Dmel\\CG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, LLGL1, misb, PSD-95, psd95, SAP-90, Sap90, SAP90A, SAP97

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Am meisten referenzierte anti-Discs, Large Homolog 4 (Drosophila) Antikörper

  1. Human Monoclonal DLG4 Primary Antibody für BP, ChIP - ABIN4348100 : Fogel, Akins, Krupp, Stagi, Stein, Biederer: SynCAMs organize synapses through heterophilic adhesion. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)
    Zeige alle 11 Referenzen für 4348100

  2. Cow (Bovine) Monoclonal DLG4 Primary Antibody für AA, ICC - ABIN361694 : Cai, Li, Rivera, Keinänen: Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors. in The Journal of biological chemistry 2006 (PubMed)
    Zeige alle 7 Referenzen für 361694

  3. Mouse (Murine) Monoclonal DLG4 Primary Antibody für IF, IP - ABIN968002 : Brenman, Chao, Gee, McGee, Craven, Santillano, Wu, Huang, Xia, Peters, Froehner, Bredt: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. in Cell 1996 (PubMed)
    Zeige alle 5 Referenzen für 968002

  4. Human Polyclonal DLG4 Primary Antibody für IF (p), IHC (p) - ABIN725930 : Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014 (PubMed)
    Zeige alle 4 Referenzen für 725930

  5. Cow (Bovine) Monoclonal DLG4 Primary Antibody für AA, ICC - ABIN2484816 : Yao, Gainetdinov, Arbuckle, Sotnikova, Cyr, Beaulieu, Torres, Grant, Caron: Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. in Neuron 2004 (PubMed)
    Zeige alle 2 Referenzen für 2484816

  6. Cow (Bovine) Monoclonal DLG4 Primary Antibody für AA, ICC - ABIN2484813 : Cline: Synaptogenesis: a balancing act between excitation and inhibition. in Current biology : CB 2005 (PubMed)
    Zeige alle 2 Referenzen für 2484813

  7. Mouse (Murine) Polyclonal DLG4 Primary Antibody für WB - ABIN152631 : Reissner, Boyle, Ye, Carew: Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. in Journal of neurochemistry 2008 (PubMed)

Weitere Antikörper gegen Discs, Large Homolog 4 (Drosophila) Interaktionspartner

Fruit Fly (Drosophila melanogaster) Discs, Large Homolog 4 (Drosophila) (DLG4) Interaktionspartner

  1. Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (zeige ACD Antikörper)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (zeige ACD Antikörper), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.

  2. The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.

  3. Loss of scrib (zeige SCRIB Antikörper), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (zeige SCRIB Antikörper) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  4. Gliotactin and Discs large are co-regulated to maintain epithelial integrity.

  5. Hts (zeige APCDD1 Antikörper) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.

  6. Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.

  7. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization

  8. Study provide evidence that scrib (zeige SCRIB Antikörper) and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib (zeige SCRIB Antikörper) and dlg act in a common pathway to regulate PFC (zeige CFP Antikörper) fate induction.

  9. integrins act through CaMKII (zeige CAMK2 Antikörper) activation to control the localization of dlg in the development of NMJ synaptic morphology

  10. conclude that Dlg/Scrib (zeige SCRIB Antikörper)/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts

Mouse (Murine) Discs, Large Homolog 4 (Drosophila) (DLG4) Interaktionspartner

  1. In Fmr1 (zeige FMR1 Antikörper) KO neurons, Mdm2 (zeige MDM2 Antikörper) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Antikörper) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Antikörper) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 Antikörper) KO. Expression of a dephosphomimetic of Mdm2 (zeige MDM2 Antikörper) rescues PSD-95 ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 Antikörper) KO neurons.

  2. tested the effect of five targeted mouse mutations on the assembly of known PSD95 interactors, Kir2.3 (zeige KCNJ4 Antikörper), Arc (zeige NOL3 Antikörper), IQsec2/BRAG1 (zeige IQSEC2 Antikörper) and Adam22 (zeige ADAM22 Antikörper)

  3. Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.

  4. PSD95 and SYP (zeige PTPN11 Antikörper) may originate from the different sites, but they are closely related to the formation and maturation of synapse.

  5. Expression levels of brain derived neurotrophic factor, postsynaptic density 95, and p-cyclic-AMP response element binding protein levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.

  6. The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN (zeige SYP Antikörper) and PSD95 expression, which is critical for structural synaptic plasticity.

  7. critical roles of PSD-95 in regulating synaptic kainate receptors.

  8. Phenylketonuric mice given a specific nutrient combination showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1 (zeige CA1 Antikörper)) and cornus ammonis 3 (CA3 (zeige CA3 Antikörper)) pyramidal cell layer.

  9. Lambda-cyhalothrin (LCT (zeige LCT Antikörper)) could increase the PSD95 protein level via the ERalpha (zeige ESR1 Antikörper)-dependent Akt (zeige AKT1 Antikörper) pathway, and LCT (zeige LCT Antikörper) might disrupt the up-regulation effect of estradiol on PSD95 protein expression via this signaling pathway.

  10. Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95) and cyclin-dependent kinase 5 (CDK5 (zeige CDK5 Antikörper)) levels.

Human Discs, Large Homolog 4 (Drosophila) (DLG4) Interaktionspartner

  1. This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder.

  2. These results indicate that PKC (zeige PRRT2 Antikörper) promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 (zeige MAPK8 Antikörper) and calcium/calmodulin-dependent kinase (zeige CAMK2 Antikörper) II and also by inducing expression of PSD-95 and synaptophysin (zeige SYP Antikörper).

  3. The differences in cortical NMDAR (zeige GRIN1 Antikörper) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.

  4. Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.

  5. Data demonstrate a role for SNAP-25 (zeige SNAP25 Antikörper) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.

  6. Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ (zeige INADL Antikörper) domains.

  7. In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles

  8. An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.

  9. Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (zeige SYP Antikörper) and before neuronal loss in patients with Alzheimer's disease.

  10. The postsynaptic membrane protein PSD95 was increased in schizophrenia in CA3 (zeige CA3 Antikörper) tissue, but not in CA1 (zeige CA1 Antikörper) tissue.

Discs, Large Homolog 4 (Drosophila) (DLG4) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Discs, Large Homolog 4 (Drosophila) (DLG4)

  • discs large 1 (dlg1) Antikörper
  • discs, large homolog 4 (dlg4) Antikörper
  • lethal giant larvae homolog 1 (Drosophila) (DLG4) Antikörper
  • discs, large homolog 4 (Drosophila) (DLG4) Antikörper
  • discs, large (Drosophila) homolog 4 (dlg4) Antikörper
  • discs, large homolog 4 (Drosophila) (Dlg4) Antikörper
  • lethal giant larvae homolog 1 (Drosophila) (LLGL1) Antikörper
  • 11 Antikörper
  • anon-EST:Posey93 Antikörper
  • anon-WO03040301.258 Antikörper
  • anon-WO03040301.260 Antikörper
  • anon-WO03040301.268 Antikörper
  • CG1725 Antikörper
  • CG1730 Antikörper
  • CPD Antikörper
  • d. lg.-1 Antikörper
  • Discs-large Antikörper
  • dlg Antikörper
  • dlg-1 Antikörper
  • dlg-A Antikörper
  • Dlg1 Antikörper
  • DLG4 Antikörper
  • dlgA Antikörper
  • Dlgh4 Antikörper
  • dlgS97 Antikörper
  • Dmel\\CG1725 Antikörper
  • Drodlg Antikörper
  • l(1)10Bf Antikörper
  • l(1)bwn Antikörper
  • l(1)d.lg-1 Antikörper
  • l(1)d.lg.-1 Antikörper
  • l(1)discs large Antikörper
  • l(1)dlg Antikörper
  • l(1)dlg-1 Antikörper
  • l(1)dlg1 Antikörper
  • l(1)G0276 Antikörper
  • l(1)G0342 Antikörper
  • l(1)G0456 Antikörper
  • l(1)G19 Antikörper
  • l(1)l.pr.-2 Antikörper
  • l(1)L11 Antikörper
  • l(1)lpr-2 Antikörper
  • LLGL1 Antikörper
  • misb Antikörper
  • PSD-95 Antikörper
  • psd95 Antikörper
  • SAP-90 Antikörper
  • Sap90 Antikörper
  • SAP90A Antikörper
  • SAP97 Antikörper

Bezeichner auf Proteinebene für DLG4

CG1725-PA , CG1725-PB , CG1725-PC , CG1725-PD , CG1725-PE , CG1725-PF , CG1725-PG , CG1725-PH , CG1725-PI , CG1725-PJ , CG1725-PK , CG1725-PL , CG1725-PM , CG1725-PN , CG1725-PO , CG1725-PP , CG1725-PQ , CG1725-PR , CG1725-PS , CG1725-PT , CG1725-PU , Disc-large , Discs-large , disc large , discs large , discslarge , disk large , dlg1-PA , dlg1-PB , dlg1-PC , dlg1-PD , dlg1-PE , dlg1-PF , dlg1-PG , dlg1-PH , dlg1-PI , dlg1-PJ , dlg1-PK , dlg1-PL , dlg1-PM , dlg1-PN , dlg1-PO , dlg1-PP , dlg1-PQ , dlg1-PR , dlg1-PS , dlg1-PT , dlg1-PU , lethal(1)benign wing imaginal disc neoplasm , lethal(1)discs large , lethal(1)discs-large , lethal(2)discs large , discs, large homolog 4 , postsynaptic density protein 95 , disks large homolog 4 , PSD-95 , PSD95/SAP90 , PSD-95 alpha 2b , PSD-95 beta , SAP-90 , discs large homolog 4 , synapse-associated protein 90 , synapse-associated protein SAP90 , Tax interaction protein 15 , post-synaptic density protein 95

GENE ID SPEZIES
32083 Drosophila melanogaster
779559 Xenopus (Silurana) tropicalis
468444 Pan troglodytes
489462 Canis lupus familiaris
100137840 Bos taurus
405796 Danio rerio
13385 Mus musculus
29495 Rattus norvegicus
1742 Homo sapiens
100339587 Oryctolagus cuniculus
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