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TAZ (zeige TAZ Proteine) negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors.
structural and functional analysis of the YAP (zeige YAP1 Proteine)-binding domain of human TEAD2
Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc (zeige MYC Proteine) RNA expression, and cells with increased Myc (zeige MYC Proteine) expression also became super-competitors.
Tead2 transcription factors are crucial regulators of the cellular distribution of Yap (zeige YAP1 Proteine) and Taz (zeige TAZ Proteine), and together they control the expression of genes critical for EMT (zeige ITK Proteine) and metastasis.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP (zeige YAP1 Proteine)/TEAD pathway
These findings provide proof of principle that inhibiting TEAD-YAP (zeige YAP1 Proteine) interactions is a pharmacologically viable strategy against the YAP (zeige YAP1 Proteine) oncoprotein.
YAP (zeige YAP1 Proteine), TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF (zeige LIF Proteine).
The transcription factors ETF, E2F1 (zeige E2F1 Proteine), and SP-1 (zeige SP1 Proteine) seem to play a pronounced role in mediating proliferation-dependent differential gene expression in liver.
Results suggest that DNA methylation (zeige HELLS Proteine) is not the primary determinant of Soggy/Tead2 expression.
novel MyoD (zeige MYOD1 Proteine)-Tead2-Fgfr4 (zeige FGFR4 Proteine) pathway important for effective muscle regeneration
Tead2-deficient mice provide a model for anencephaly.
Tead1 (zeige TEAD1 Proteine) and Tead2 are functionally redundant, use YAP (zeige YAP1 Proteine) as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in development.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
TEA domain family member 2
, transcriptional enhancer factor TEF-4-like
, transcriptional enhancer factor TEF-4
, embryonic TEA domain-containing factor
, Embryonic TEA domain containing factor