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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (zeige ATP7A Proteine), sp1 and sod1 (zeige SOD1 Proteine) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
High SP1 (zeige PSG1 Proteine) expression is associated with obesity.
The up-regulation of Hsp27 (zeige HSPB1 Proteine) by E2 is mediated by ERalpha (zeige ESR1 Proteine)/Sp1 (zeige PSG1 Proteine).
Identification of heteromolecular binding sites in transcription factors Sp1 (zeige PSG1 Proteine) and TAF4 (zeige TAF4 Proteine) using high-resolution nuclear magnetic resonance spectroscopy has been reported.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45 (zeige GADD45A Proteine)-NER (zeige NR1H2 Proteine) pathway.
TIP60 (zeige KAT5 Proteine)-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (zeige TERT Proteine) repression through Sp1 (zeige PSG1 Proteine) acetylation. In summary, our study has identified a novel substrate for TIP60 (zeige KAT5 Proteine) catalytic activity and a unique repressive mechanism acting at the TERT (zeige TERT Proteine) promoter in virus-induced malignancies.
AGEs treatment increased the expression of RAGE (zeige AGER Proteine), Sp1 (zeige PSG1 Proteine), and MMP2 (zeige MMP2 Proteine) in a dose-dependent manner.
E6 upregulation of hTERT by downregulated LKB1 (zeige STK11 Proteine) and upregulated SP1 (zeige PSG1 Proteine) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Results have shown crosstalk among the EGFR (zeige EGFR Proteine) cascade and Sp1 (zeige PSG1 Proteine) and DPD (zeige DPYD Proteine) expressions in EGFR (zeige EGFR Proteine) mutant non-small-cell lung cancer cell lines. EGF (zeige EGF Proteine)-induced Sp1 (zeige PSG1 Proteine) up-regulation resulted in both DPYD (zeige DPYD Proteine) mRNA and DPD (zeige DPYD Proteine) protein expressions.
AKT (zeige AKT1 Proteine)/GSK-3beta-mediated stabilization of SP1 (zeige PSG1 Proteine) is required for TGF-beta (zeige TGFB1 Proteine) induced up-regulation of NKG2DLs.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG (zeige PPARG Proteine) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (zeige PTH Proteine) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (zeige PRNP Proteine) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (zeige PRNP Proteine) promoter and its activity.
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (zeige NFATC1 Proteine) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (zeige MLXIP Proteine)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (zeige SIRT1 Proteine) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (zeige IFRD1 Proteine), Sp1 and mSIN3B, which is a component of the SIN (zeige POLR3E Proteine) complex containing histone deacetylase (zeige HDAC1 Proteine), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (zeige IFRD1 Proteine) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (zeige DMD Proteine) expression in hepatic cells is carried out, in part, by YY1 (zeige YY1 Proteine)-, Sp1- and Sp3-mediated transcription from the Dp71 (zeige DMD Proteine) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (zeige MLXIP Proteine)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 (zeige YY1 Proteine) and SP1 independently and cooperatively govern the Mesp1 (zeige MESP1 Proteine) expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1