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SP1 Proteine (SP1)

Sp1 Transcription Factor Proteine (SP1)
Auf finden Sie aktuell 9 Sp1 Transcription Factor (SP1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SP1 Antikörper (276) und SP1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 323 SP1 Produkte verfügbar.
1110003E12Rik, AA450830, AI845540, fc18h09, SP1, Sp1-1, wu:fc18h09, zgc:85950
alle Proteine anzeigen Gen GeneID UniProt
SP1 6667 P08047
Ratte SP1 SP1 24790 Q01714
SP1 20683 O89090

Weitere Synonyme anzeigen

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Weitere Proteine zu SP1 Interaktionspartnern

Zebrafish Sp1 Transcription Factor (SP1) Interaktionspartner

  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (zeige ATP7A Proteine), sp1 and sod1 (zeige SOD1 Proteine) in zebrafish.

  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Human Sp1 Transcription Factor (SP1) Interaktionspartner

  1. aken together, our results suggest that Sp1 (zeige PSG1 Proteine) plays a role in human osteoblast differentiation and mineralization, which is at least partially mediated by Sp1 (zeige PSG1 Proteine)-dependent transactivation of FZD1 (zeige Fzd1 Proteine).

  2. The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (zeige TGFB1 Proteine)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.

  3. cells transduced with siSp1 exhibited dramatically decreased ICAM-1 (zeige ICAM1 Proteine) expression. These results proved that the up-regulation of ICAM-1 (zeige ICAM1 Proteine) with hyperglycaemia is mediated by O-GlcNAc (zeige OGT Proteine) modification of Sp1 (zeige PSG1 Proteine)

  4. these findings show that SP1-activated LINC00673 exerts an oncogenic function that promotes GC development and progression, at least in part, by functioning as a scaffold for LSD1 and EZH2 and repressing KLF2 and LATS2 expression.

  5. During LPS (zeige IRF6 Proteine) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (zeige PSG1 Proteine) dependent transcriptional regulation.

  6. The mRNA levels of ACSL1 (zeige Acsl1 Proteine) were positively associated with those of HBXIP (zeige HBXIP Proteine) in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP (zeige HBXIP Proteine) is able to up-regulate ACSL1 (zeige Acsl1 Proteine) through activating the transcriptional factor Sp1 (zeige PSG1 Proteine) in breast cancer.

  7. hTERT facilitates tumor angiogenesis by up-regulating VEGF (zeige VEGFA Proteine) expression through direct interactions with the VEGF (zeige VEGFA Proteine) gene and the Sp1 transcription factor.

  8. Using mass spectrometry and site directed mutagenesis, a new Sp1 (zeige PSG1 Proteine) phosphorylation site Ser702 was defined to be associated with Sp1 (zeige PSG1 Proteine)-HDAC1 (zeige HDAC1 Proteine) interaction and may be important in SR-BI (zeige SCARB1 Proteine) activation, shedding light on the knowledge of delicate mechanism of hepatic HDL (zeige HSD11B1 Proteine) receptor SR-BI (zeige SCARB1 Proteine) gene modulation by LDL.

  9. Results show that hyperglycemia-induced upregulation of Robo4 (zeige ROBO4 Proteine) in retinal endothelial cells is directly mediated by transcription factor SP1 which increases the transcription of Robo4 (zeige ROBO4 Proteine) via an additional binding site in Robo4 (zeige ROBO4 Proteine) promoter. SP1 (zeige PSG1 Proteine)/Robo4 (zeige ROBO4 Proteine) can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.

  10. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.

Cow (Bovine) Sp1 Transcription Factor (SP1) Interaktionspartner

  1. study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG (zeige PPARG Proteine) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation

  2. likely involvement of the Sp family in regulating PTH (zeige PTH Proteine) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.

  3. These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.

  4. The coordinate regulation of the bovine PRNP (zeige PRNP Proteine) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (zeige PRNP Proteine) promoter and its activity.

Mouse (Murine) Sp1 Transcription Factor (SP1) Interaktionspartner

  1. Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (zeige NFATC1 Proteine) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (zeige MLXIP Proteine)-139-5p expression and promote osteoclastogenesis.

  2. data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (zeige SIRT1 Proteine) signaling pathway.

  3. This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes

  4. adrenergic stimulation induced complex formation between Ifrd1 (zeige IFRD1 Proteine), Sp1 and mSIN3B, which is a component of the SIN (zeige POLR3E Proteine) complex containing histone deacetylase (zeige HDAC1 Proteine), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (zeige IFRD1 Proteine) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.

  5. Dp71 (zeige DMD Proteine) expression in hepatic cells is carried out, in part, by YY1 (zeige YY1 Proteine)-, Sp1- and Sp3-mediated transcription from the Dp71 (zeige DMD Proteine) promoter.

  6. SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.

  7. miR (zeige MLXIP Proteine)-124, -128, and -137 act synergistically to regulate Sp1 expression.

  8. YY1 (zeige YY1 Proteine) and SP1 independently and cooperatively govern the Mesp1 (zeige MESP1 Proteine) expression during embryogenesis.

  9. Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes.

  10. In the initial stage of myocyte differentiation, transcription of the YB-1 (zeige YBX1 Proteine) gene was regulated by E2F1 (zeige E2F1 Proteine) and Sp1, and was then gradually replaced under the control of both MyoD (zeige MYOD1 Proteine) and myogenin (zeige MYOG Proteine).

SP1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SP1

  • sp1 transcription factor (sp1)
  • Sp1 transcription factor (sp1)
  • Sp1 transcription factor (SP1)
  • Sp1 transcription factor (LOC100351317)
  • Sp1 transcription factor (Sp1)
  • trans-acting transcription factor 1 (Sp1)
  • 1110003E12Rik Protein
  • AA450830 Protein
  • AI845540 Protein
  • fc18h09 Protein
  • SP1 Protein
  • Sp1-1 Protein
  • wu:fc18h09 Protein
  • zgc:85950 Protein

Bezeichner auf Proteinebene für Sp1 Transcription Factor Proteine (SP1)

Sp1-like protein , transcription factor Sp1 , transcription factor , Sp1 transcription factor , transcription factor Sp1-like , specificity protein 1 , specific protein-1 , trans-acting transcription factor 1

324109 Danio rerio
394744 Xenopus (Silurana) tropicalis
451939 Pan troglodytes
702710 Macaca mulatta
100351317 Oryctolagus cuniculus
100407824 Callithrix jacchus
100440745 Pongo abelii
100474983 Ailuropoda melanoleuca
100553756 Anolis carolinensis
100585963 Nomascus leucogenys
6667 Homo sapiens
540741 Bos taurus
24790 Rattus norvegicus
397314 Sus scrofa
431939 Xenopus laevis
395303 Gallus gallus
486507 Canis lupus familiaris
100303456 Ovis aries
20683 Mus musculus
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