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Human ANGPTL4 ELISA Kit für Sandwich ELISA - ABIN624942
Drager, Yao, Hernandez, Shin, Bevans-Fonti, Gay, Sussan, Jun, Myers, Olivecrona, Schwartz, Halberg, Scherer, Semenza, Powell, Polotsky: Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. in American journal of respiratory and critical care medicine 2013
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Human ANGPTL4 ELISA Kit für Sandwich ELISA - ABIN414519
Ortega-Senovilla, Schaefer-Graf, Meitzner, Abou-Dakn, Herrera et al.: Decreased concentrations of the lipoprotein lipase inhibitor angiopoietin-like protein 4 and increased serum triacylglycerol are associated with increased neonatal fat mass in pregnant women with ... in The Journal of clinical endocrinology and metabolism 2013
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Mouse (Murine) ANGPTL4 ELISA Kit für Sandwich ELISA - ABIN424561
Gray, Lam, Yang, Zhou, Koliwad, Wang: Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes. in The Journal of biological chemistry 2012
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Rat (Rattus) ANGPTL4 ELISA Kit für Sandwich ELISA - ABIN626662
Li, Chen, Peng, Wei, Zhao, Diao, He, Liu, Wei, Zhang, Li: Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. in PLoS ONE 2015
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Cow (Bovine) ANGPTL4 ELISA Kit für Sandwich ELISA - ABIN825764
Wang, Zhu, Wang, Yao, Zhao, Liu: Non-esterified fatty acids promote expression and secretion of angiopoietin-like protein 4 in calf hepatocytes cultured in vitro. in Molecular and cellular biochemistry 2014
increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow
These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.
1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut (zeige GUSB ELISA Kits) microbiota.
physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL (zeige LPL ELISA Kits) in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL (zeige LPL ELISA Kits) by stimulating LPL (zeige LPL ELISA Kits) degradation after LPL (zeige LPL ELISA Kits) processing in the endoplasmic reticulum (ER).
This study shows that TNF-alpha (zeige TNF ELISA Kits), by a Foxo1 (zeige FOXO1 ELISA Kits) dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL (zeige LPL ELISA Kits).
Angptl4-deficient mice show impaired insulin (zeige INS ELISA Kits) secretion and dysmorphic pancreatic islets.
Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin (zeige INS ELISA Kits) resistance, in addition to causing the downregulation of various insulin (zeige INS ELISA Kits) signaling pathway-associated genes.
ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to brown adipose tissue during cold.
This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 (zeige ANGPTL3 ELISA Kits) and Angptl4 at different nutritional statuses.
These results reveal that FTO (zeige FTO ELISA Kits) regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4.
these results suggest that IL-1beta (zeige IL1B ELISA Kits) increases Angptl4 expression through a mechanism dependent on the JNK (zeige MAPK8 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits) signaling pathway in MC3T3-E1 cells.
glucagon receptor (zeige GCGR ELISA Kits) antagonist improves glycemia in diet-induced obese angptl4 knockout mice without increasing glucagon (zeige GCG ELISA Kits) levels or alpha-cell proliferation, underscoring the importance of this protein.
The authors now show: (1) that ANGPTL4 inactivates LPL (zeige LCP1 ELISA Kits) by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 (zeige GPIHBP1 ELISA Kits) renders LPL (zeige LCP1 ELISA Kits) largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 (zeige GPIHBP1 ELISA Kits) are required for this protective effect.
One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene.
reduced expression of one of the survival-associated transcripts, Angiopoietin-like 4, impairs growth of a gemcitabine-resistant pancreatic cancer cell line.
Serum ANGPTL4 is elevated in coronary artery disease, but levels do not reflect severity of disease.
identify ANGPTL4 as a Wnt (zeige WNT2 ELISA Kits) signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt (zeige WNT2 ELISA Kits) co-receptor Lipoprotein receptor-related protein 6 (zeige LRP6 ELISA Kits)
results suggest that ANGPTL4 could contribute to the development of retinal neovascularization in sickle cell patients and could therefore be a therapeutic target for the treatment of PSR (zeige JMJD6 ELISA Kits)
Data suggest that purified FLD (zeige LPIN1 ELISA Kits) (C-terminal fibrinogen-like domain) of ANGPTL4 is sufficient to stimulate lipolysis in primary adipocytes; increasing circulating FLD (zeige LPIN1 ELISA Kits) levels in mice not only induces white adipose tissue lipolysis in vivo but also reduces diet-induced obesity without affecting LPL (lipoprotein lipase (zeige LPL ELISA Kits)) activity; increasing systemic FLD (zeige LPIN1 ELISA Kits) levels induces beige (zeige LYST ELISA Kits) conversion in white adipose tissue.
enhanced expression of angiopoietin-like 4 in rheumatoid arthritis may explain the occurrence of insulin (zeige INS ELISA Kits) resistance, cardiovascular risk, and joint destruction [review]
Neither serum nor urine Angptl4 appear to be good biomarkers in minimal change disease. Elevated urinary Angptl4 in glomerular disease appears to reflect the degree of proteinuria rather than any specific disease.
results reveal that liganded GR spatiotemporally controls ANGPTL4 transcription in a chromosomal context.
The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat
These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
, Angiopoietin-related protein 4
, angiopoietin-related protein 4-like
, angiopoietin-like protein 4
, angiopoietin-related protein 4
, fasting-induced adipose factor
, fibrinogen/angiopoietin-related protein
, hepatic fibrinogen/angiopoietin-related protein
, major histocompatibility complex region NG27
, secreted protein Bk89
, PPARG angiopoietin related protein
, hepatic angiopoietin-related protein
, peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
, PPARG angiopoietin-related protein
, angiopoietin-like secreted glycoprotein 4
, angiopoietin-like 4 protein