TXK tyrosine Kinase Proteine (TXK)

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Synonyme:
A130089B16Rik, Btkl, CTK-1, PSCTK5, PTK4, Rlk, TKL
alle Proteine anzeigen Gen GeneID UniProt
TXK 7294 P42681
TXK 22165 P42682
TXK 305311  

TXK tyrosine Kinase Proteine (TXK) nach Spezies

Weitere Proteine zu TXK tyrosine Kinase Interaktionspartnern

Human TXK tyrosine Kinase (TXK) Interaktionspartner

  1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK (zeige ITK Proteine) and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.

  2. fuctions as a Th1 (zeige TH1L Proteine) cell-specific transcription factor and regulates IFN-gamma (zeige IFNG Proteine) gene transcription

  3. Th1 (zeige TH1L Proteine) cells expressing Txk and Th1 (zeige TH1L Proteine)-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.

  4. Itk (zeige ITK Proteine) and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 (zeige TH1L Proteine) responses.

Mouse (Murine) TXK tyrosine Kinase (TXK) Interaktionspartner

  1. Taken together, these data indicate that ITK (zeige ITK Proteine) plus RLK inhibition may have therapeutic potential in Th1 (zeige HAND1 Proteine)-mediated inflammatory diseases.

  2. TXK plays an overlapping role with ITK (zeige ITK Proteine) in iNKT cell development and function. ITK (zeige ITK Proteine) also has a unique function in the survival of iNKT cells, likely via a p53 (zeige TP53 Proteine)-dependent pathway.

  3. The protein data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk (zeige ITK Proteine) proteins

  4. Tec kinases play key roles in regulating TCR-mediated polarization of integrins and signaling molecules to the site of TCR stimulation as well as the up-regulation of integrin adhesion.

  5. A role for Rlk kinase is demonstrated in CD8 (zeige CD8A Proteine)+ T cell signaling and function both in vitro and in vivo.

  6. indicate a critical role for Itk (zeige ITK Proteine) and Rlk in conventional CD8 (zeige CD8A Proteine)(+) T cell development in the thymus

  7. Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes

  8. Tec (zeige NR4A3 Proteine) kinases Rlk and Itk (zeige ITK Proteine) together provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of natural killer T (NKT (zeige CTSL1 Proteine)) cells.

TXK tyrosine Kinase (TXK) Protein Überblick

Protein Überblick

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Alternative names and synonyms associated with TXK tyrosine Kinase (TXK)

  • TXK tyrosine kinase (TXK)
  • insulin receptor (INSR)
  • Janus kinase 1 (JAK1)
  • spleen tyrosine kinase (SYK)
  • TXK tyrosine kinase (Txk)
  • A130089B16Rik Protein
  • Btkl Protein
  • CTK-1 Protein
  • PSCTK5 Protein
  • PTK4 Protein
  • Rlk Protein
  • TKL Protein

Bezeichner auf Proteinebene für TXK tyrosine Kinase Proteine (TXK)

tyrosine-protein kinase TXK , TXK tyrosine kinase , tyrosine-protein kinase TXK-like , insulin receptor tyrosine kinase , tyrosine kinase , Janus kinase 1 (a protein tyrosine kinase) , protein tyrosine kinase , protein-tyrosine kinase , tyrosine-protein kinase SYK , PTK4 protein tyrosine kinase 4 , protein-tyrosine kinase 4 , resting lymphocyte kinase , PTK-RL-18

GENE ID SPEZIES
444993 Sus scrofa
461344 Pan troglodytes
482139 Canis lupus familiaris
504782 Bos taurus
705104 Macaca mulatta
770387 Gallus gallus
100019276 Monodelphis domestica
100054343 Equus caballus
100341671 Oryctolagus cuniculus
100397226 Callithrix jacchus
100455862 Pongo abelii
100464564 Ailuropoda melanoleuca
100544958 Meleagris gallopavo
100598060 Nomascus leucogenys
420133 Gallus gallus
442952 Canis lupus familiaris
100125540 Sus scrofa
7294 Homo sapiens
22165 Mus musculus
305311 Rattus norvegicus
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