Nucleoside Phosphorylase Proteine (NP)

Nucleoside Phosphorylase Proteine (NP)
Auf finden Sie aktuell 18 Nucleoside Phosphorylase (NP) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nucleoside Phosphorylase Antikörper (66) und Nucleoside Phosphorylase Kits (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 106 Nucleoside Phosphorylase Produkte verfügbar.
AL024301, AU015798, fc27g06, NP, Np-1, Np-2, Pnp1, PRO1837, PUNP, wu:fc27g06, wu:fd51h11, zgc:77008
alle Proteine anzeigen Gen GeneID UniProt
NP 290029  
NP 4860 P00491
NP 18950 P23492

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Am meisten referenzierte Nucleoside Phosphorylase Proteine

  1. Human NP Protein expressed in Escherichia coli (E. coli) - ABIN2005043 : Canduri, Silva, dos Santos, Palma, Basso, Santos, de Azevedo: Structure of human PNP complexed with ligands. in Acta crystallographica. Section D, Biological crystallography 2005 (PubMed)
    Zeige alle 2 Referenzen für 2005043

  2. Human NP Protein expressed in Escherichia coli (E. coli) - ABIN667267 : Balakrishnan, Verma, OBrien, Kilpatrick, Chen, Tyler, Bickel, Bantia, Keating, Kantarjian, Gandhi, Ravandi: Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. in Blood 2010 (PubMed)
    Zeige alle 2 Referenzen für 667267

Weitere Proteine zu Nucleoside Phosphorylase Interaktionspartnern

Cow (Bovine) Nucleoside Phosphorylase (NP) Interaktionspartner

  1. the biological role of packing of the PNP monomers into a trimeric structure

  2. crystal structure complexed with analogs of the inhibitor 2-diaminopurine aglycone (purine nucleoside phosphorylase)

  3. PNP purine nucleoside phosphorylase was crystallized in space group P2(1)2(1)2(1) in the presence of (S)-PMPDAP and phosphate, and the resulting structure of the binary PNP/(S)-PMPDAP complex was refined at 2.05A resolution.

  4. alf (zeige GTF2A1L Proteine) spleen enzyme is a homotrimer and previous suggestions for dissociation of this enzyme into more active monomers, upon dilution of the enzyme or addition of phosphate, are incorrect.

  5. PCR amplification of the calf phosphorylase from the calf spleen library, cloning, overexpression of the recombinant PNP, its enzymatic activity and interactions with typical ligands of mammalian wild type PNP are described.

  6. The transition-state structure of triple mutant PNP is altered as a consequence of the amino acids in the second sphere from the catalytic site.

Human Nucleoside Phosphorylase (NP) Interaktionspartner

  1. Data show that the mutations in purine nucleoside phosphorylase (PNP) alters the enthalpy-entropy balance with little effect on the catalytic rates.

  2. Data (including data from empirical valence bond/molecular dynamic simulations) suggest that PNP substrate specificity for inosine and guanosine is a direct result of electrostatic preorganization energy along the reaction coordinate.

  3. the binding mechanism of a transition state analogue (DADMe-immucillin-H) to the purine nucleoside phosphorylase (PNP) enzyme, is reported.

  4. Data show that [15N, 2H]His8-purine nucleoside phosphorylase (PNP) had reduced catalytic site chemistry larger than proportional to the enzymatic mass difference.

  5. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase (zeige CDK7 Proteine), cyclic GMP (zeige NT5C2 Proteine)-dependent, type I (PRKG1 (zeige PRKG1 Proteine)) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP) rs1049564 (P(Meta) = 1.24 x 10(-7)).

  6. Human small intestine is a key site for ribavirin phosphorolysis and that PNP is primarily involved in the metabolism.

  7. Complete lack of PNP triggers accumulation of deoxyguanosine, thereby disrupting B-cell development, the consequence of which is more profound with time, as was found in the older sister.

  8. Biochemical and genetic data on a cohort of seven patients from six families identified as PNPase (zeige PNPT1 Proteine) deficient, is reported.

  9. This study for the first time describes elevated levels of alpha synuclein in pancreatic adenocarcinoma as well as highlights the potential of evaluating NP protein expression.

  10. investigation of catalytic mechanisms involved in catalysis by PNP: transition states in arsenolysis and phosphorolysis

Mouse (Murine) Nucleoside Phosphorylase (NP) Interaktionspartner

  1. PNP deficiency causes cerebellar abnormalities, including Purkinje cell damage and progressive motor deficits.

  2. PNP is important for the survival of DP thymocytes. Accumulation of dGuo in cases of PNP deficiency leads to mitochondria-initiated apoptosis of DP thymocytes, which can be prevented by restoring PNP activity in the cells.

Nucleoside Phosphorylase (NP) Protein Überblick

Protein Überblick

This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Alternative names and synonyms associated with Nucleoside Phosphorylase (NP)

  • purine nucleoside phosphorylase 5a (pnp5a)
  • diacylglycerol kinase, eta (DGKH)
  • purine nucleoside phosphorylase (Pnp)
  • purine nucleoside phosphorylase (PNP)
  • purine-nucleoside phosphorylase (Pnp)
  • AL024301 Protein
  • AU015798 Protein
  • fc27g06 Protein
  • NP Protein
  • Np-1 Protein
  • Np-2 Protein
  • Pnp1 Protein
  • PRO1837 Protein
  • PUNP Protein
  • wu:fc27g06 Protein
  • wu:fd51h11 Protein
  • zgc:77008 Protein

Bezeichner auf Proteinebene für Nucleoside Phosphorylase Proteine (NP)

inosine phosphorylase , inosine-guanosine phosphorylase , nucleoside phosphorylase , purine-nucleoside:orthophosphate ribosyltransferase , purine nucleoside phosphorylase , purine-nucleoside phosphorylase 1

791647 Danio rerio
537533 Bos taurus
290029 Rattus norvegicus
4860 Homo sapiens
493724 Bos taurus
475393 Canis lupus familiaris
769958 Gallus gallus
100718329 Cavia porcellus
100157138 Sus scrofa
18950 Mus musculus
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