F2RL1 Proteine (F2RL1)

Bezeichnung:
Coagulation Factor II (thrombin) Receptor-Like 1 Proteine (F2RL1)
Auf www.antikoerper-online.de finden Sie aktuell 7 Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen F2RL1 Antikörper (43) und F2RL1 Kits (39) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 95 F2RL1 Produkte verfügbar.
Synonyme:
Gpcr11, GPR11, Par-2, Par2
alle Proteine anzeigen Gen GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
Ratte F2RL1 F2RL1 116677 Q63645

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Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

  1. TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (zeige SMAD3 Proteine) that is indispensable for the maintenance of vascular integrity.

  2. PAR-2- and PAR-1 (zeige MARK2 Proteine)-mediated TNF-alpha (zeige TNF Proteine) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.

  3. Results indicate that chymotrypsin-like serine protease (zeige F2 Proteine) enhances soluble fms-like tyrosine kinase 1 (zeige FLT1 Proteine) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.

  4. crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody

  5. PAR-2 plays an important role in the progression of ovarian clear cell carcinoma.

  6. Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling, inactivates GSK3b signaling, leads to accumulation of beta-catenin (zeige CTNNB1 Proteine), and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (zeige F3 Proteine); PI3K (zeige PIK3CA Proteine) = phosphatidylinositol 3-kinase; AKT (zeige AKT1 Proteine) = proto-oncogene (zeige RAB1A Proteine) protein c-akt (zeige AKT1 Proteine); GSK3b = glycogen synthase kinase 3 beta)

  7. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.

  8. Studies provide increasing evidence that PAR2 plays a significant role in inflammatory diseases both in the periphery and in the CNS. There is a clear similarity between PAR2 expression and activation on cells of the immune system and those cell types that are proposed to play a role within the CNS, astrocytes and microglia. [review]

  9. Results show that PAR2 in hepatic stellate cells plays a crucial role in promoting hepatocellular carcinoma growth presumably by mediating migration and secretion of pro-angiogenic and pro-mitotic factors.

  10. Data highlight functional differences in proliferation and barrier integrity between dark keratinocytes and fair keratinocytes that are partly associated with their differential expression of PAR1 (zeige MARK2 Proteine) and PAR2.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

  1. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.

  2. Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems

  3. PAR2/GSK3beta is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.

  4. Enhanced FXa (zeige F10 Proteine) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.

  5. PAR2 is critically important in the pathogenesis of adenine-induced tubular injury

  6. The levels of miR (zeige MLXIP Proteine)-223, miR (zeige MLXIP Proteine)-339 and miR (zeige MLXIP Proteine)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (zeige F2 Proteine)-stimulated platelet-derived exosomes in vitro.

  7. Neutrophil elastase (zeige ELANE Proteine) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44 (zeige GTF2H4 Proteine)/42 MAPK (zeige MAPK1 Proteine) pathway. Blocking neutrophil elastase (zeige ELANE Proteine), PAR2 and p44 (zeige GTF2H4 Proteine)/42 MAPK (zeige MAPK1 Proteine) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.

  8. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  9. Stimulation of PAR-2 activates Nf-kappaB (zeige NFKB1 Proteine) signaling, resulting in RelA (zeige NFkBP65 Proteine) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  10. Tryptase (zeige TPSAB1 Proteine) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (zeige OVA Proteine)-induced atopic-like dermatitis

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

  1. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Protein Überblick

Protein Überblick

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Alternative names and synonyms associated with F2RL1

  • Proteinase-activated receptor 2 (par2)
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1)
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1)
  • Gpcr11 Protein
  • GPR11 Protein
  • Par-2 Protein
  • Par2 Protein

Bezeichner auf Proteinebene für F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

GENE ID SPEZIES
100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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