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Human Recoverin Protein expressed in Escherichia coli (E. coli) - ABIN666850
Sampath, Weaver, Sungarian, Cortez, Alderson, Stopa: Cerebrospinal fluid (vascular endothelial growth factor) and serologic (recoverin) tumor markers for malignant glioma. in Cancer control : journal of the Moffitt Cancer Center 2004
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High RCVRN expression is associated with renal tumors.
Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.
Aberrant hypomethylation of the recoverin gene region, overlapping the promoter up-stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells.
recoverin has a pathological role in cancer-associated retinopathy
There are cis (zeige CISH Proteine)-acting elements in the 5' non-coding region of the recoverin gene that are involved in the activation and suppression of gene expression.
Human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy.
A GRK1 (zeige GRK1 Proteine) region close to its C-terminus also seemed to be the binding site for S-modulin/recoverin.
A novel rhodopsin-kinase (zeige GRK1 Proteine)-binding site within the C-terminal region of recoverin.
(15) N NMR relaxation data suggest that Ca(2 (zeige CA2 Proteine)+)-free recoverin undergoes millisecond conformational dynamics at particular amide sites throughout the protein.
Ca2 (zeige CA2 Proteine)+-myristoyl switch in the neuronal calcium sensor requires different functions of Ca2 (zeige CA2 Proteine)+-binding sites
Recoverin is a zinc-binding protein
Recoverin and rhodopsin kinase (zeige GRK1 Proteine) have roles in a Ca2 (zeige CA2 Proteine)+-dependent feedback loop in membrane rafts from rod outer segments
an interaction surface for the recoverin target rhodopsin kinase (zeige GRK1 Proteine) is constituted upon Ca2 (zeige CA2 Proteine)+ binding to the non-acylated mutant
Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase (zeige GRK1 Proteine)
Ca2+/recoverin has a role in regulating rhodopsin mutants associated with retinitis pigmentosa
propose a novel role of the C-terminal segment of recoverin as an internal modulator of Ca(2 (zeige CA2 Proteine)+) sensitivity
Time-resolved fluorescence shows biexponential fluorescence decay. The slower time constant was affected by Ca2 (zeige CA2 Proteine)+-induced conformational changes in WT & RecE85Q (disabled EF-hand 2 (zeige HAND2 Proteine)), & not RecE121Q (EF-hand 3 nonfunctional) with a clamped myristoyl group.
Rods and cones share the same isoforms of recoverin and GRK1 (zeige GRK1 Proteine), and photoactivation also triggers a calcium decline in cones
recoverin may modulate the decay of light-activated PDE (zeige TWIST1 Proteine)*, which may be responsible for the quickening of response recovery in background light.
High anti-recoverin antibody levels were achieved in two mouse models, accompanied by significantly reduced scotopic and photopic responses on the electroretinograms.
This is the first demonstration in an intact rod that light accelerates Rh* inactivation and that the Ca(2+)-binding protein (zeige PVALB Proteine) recoverin may be required for the light-dependent modulation of Rh* lifetime.
recoverin undergoes light-dependent intracellular translocation in mouse rod photoreceptors
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy.
, cancer associated retinopathy antigen
, cancer-associated retinopathy protein
, 23 kDa photoreceptor cell-specific protein
, cancer associated retinopathy protein
, guanylate cyclase activator