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ULK1 played a crucial role in ALDH2 (zeige ALDH2 Proteine)-offered protective effect against high glucose exposure-induced cardiomyocyte injury through regulation of autophagy
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK (zeige PRKAA1 Proteine)-ULK1 signaling dysregulation independently of HIF-1A (zeige HIF1A Proteine).
phosphorylation of mATG9 (zeige ATG9A Proteine) at Tyr8 by Src (zeige SRC Proteine) and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 (zeige ATG9A Proteine) and the AP1 (zeige FOSB Proteine)/2 complex.
we found that ATG14 interacted with Ulk1 and LC3, and knock down of Ulk1 prevented the lipidation of LC3 and autophagy in HeLa-ATG14 cells. We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction.
ULK1 has a role in RPS6KB1 (zeige RPS6KB1 Proteine)-NCOR1 (zeige NCOR1 Proteine) repression of NR1H/LXR (zeige NR1H3 Proteine)-mediated Scd1 (zeige SCD Proteine) transcription and augments lipotoxicity in hepatic cells
Data show that ULK1, a protein kinase (zeige CDK7 Proteine) activated at the autophagosome formation site, phosphorylates human ATG4B (zeige ATG4B Proteine) on serine 316.
While focusing on the role of SMCR8 during autophagy initiation, we found that kinase activity and gene expression of ULK1 are increased upon SMCR8 depletion. The latter phenotype involved association of SMCR8 with the ULK1 gene locus.
despite the significant upregulation of mRNA of the essential autophagy initiation gene ULK1, its protein level is rapidly reduced under starvation.
Our findings demonstrate for the first time that miR (zeige MLXIP Proteine)-26a/b can promote apoptosis and sensitize Hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) to chemotherapy via suppressing the expression of autophagy initiator ULK1, and provide the reduction of miR (zeige MLXIP Proteine)-26a/b in HCC (zeige FAM126A Proteine) as a novel mechanism of tumor chemoresistance.
Downregulation of ULK1 inhibited the overexpression effects of miR (zeige MLXIP Proteine)-372, and upregulation of ULK1 reversed the effects of overexpressed miR (zeige MLXIP Proteine)-372 in human pancreatic adenocarcinoma cells.
ATG7 (zeige ATG7 Proteine), but not ATG13 (zeige ATG13 Proteine) or ULK1 has a role in functional autophagy in glioblastoma development
ULK1 is a novel substrate of Caspase-3 (zeige CASP3 Proteine) and upregulation of ULK1 drives autophagy initiation in leukemia cells.
Findings indicate that the PPM1D (zeige PPM1D Proteine)-Ulk1 axis plays a pivotal role in genotoxic stress-induced autophagy.
Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis.
Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle.
ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.
These results demonstrate a novel mechanism by which STAT1 (zeige STAT1 Proteine) negatively regulates ULK1 expression and autophagy.
These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1.
By enhancing PARP1 (zeige PARP1 Proteine) activity, ULK1 contributes to ATP depletion and death of H2O2-treated cells.
MUL1 (zeige MUL1 Proteine) ubiquitinates ULK1 and regulates selenite-induced mitophagy
predicted to have similarity to C. elegans serine/threonine kinase UNC-51
unc-51-like kinase 1 (C. elegans)
, serine/threonine-protein kinase ULK1
, unc-51-like kinase 1
, ATG1 autophagy related 1 homolog
, autophagy-related protein 1 homolog
, serine/threonine-protein kinase Unc51.1