SMURF1 Proteine (SMURF1)

SMAD Specific E3 Ubiquitin Protein Ligase 1 Proteine (SMURF1)
Auf finden Sie aktuell 5 SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMURF1 Antikörper (109) und SMURF1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 127 SMURF1 Produkte verfügbar.
4930431E10Rik, mKIAA1625, RGD1309707
alle Proteine anzeigen Gen GeneID UniProt
SMURF1 57154 Q9HCE7
SMURF1 75788 Q9CUN6
Ratte SMURF1 SMURF1 690516  

Weitere Synonyme anzeigen

SMURF1 Proteine (SMURF1) nach Spezies

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Am meisten referenzierte SMURF1 Proteine

  1. Human SMURF1 Protein expressed in Wheat germ - ABIN1320726 : Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013 (PubMed)

Weitere Proteine zu SMURF1 Interaktionspartnern

Human SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. SMU (zeige MLXIP Proteine)RF1 is increased in patients with pulmonary arterial hypertension

  2. Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (zeige WEE1 Proteine); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (zeige WEE1 Proteine) = wee 1 (zeige WEE1 Proteine) homolog [S pombe] protein)

  3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.

  4. results reveal the regulatory circuit between RUNX2 (zeige RUNX2 Proteine) and SMURF1 controls RUNX2 (zeige RUNX2 Proteine) expression and regulates odntoblastic differentiation in hDPSCs.

  5. EGF (zeige EGF Proteine)/Smurf1 inhibits Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (zeige CTNNB1 Proteine).

  6. a model that CD166 (zeige ALCAM Proteine) regulates MCAM (zeige MCAM Proteine) through a signaling flow from activation of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and c-Raf (zeige RAF1 Proteine)/MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) signaling to the inhibition of potential MCAM (zeige MCAM Proteine) ubiquitin E3 ligases, betaTrCP (zeige BTRC Proteine) and Smurf1.

  7. SND1 (zeige SND1 Proteine) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (zeige RHOA Proteine) ubiquitination and degradation.

  8. NF-kappaB (zeige NFKB1 Proteine) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.

  9. Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.

  10. The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (zeige CD44 Proteine)(high) expressing.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (zeige FERMT2 Proteine) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions

  2. miR (zeige MLXIP Proteine)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension

  3. Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.

  4. Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.

  5. Smurf1 mediates NGF (zeige NGFB Proteine) signaling and ubiquitinates RhoA (zeige RHOA Proteine) in growth cones, regulating the need for local translation and degradation.

  6. Smurf-mediated endocytosis of Patched1 (zeige PTCH1 Proteine) is required in sonic hedgehog (zeige SHH Proteine) signal reception

  7. Inhibition of rhBMP-2-induced ALP (zeige CCL21A Proteine) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  8. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (zeige AXIN1 Proteine) negatively regulates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  9. These results suggest that the JNK (zeige MAPK8 Proteine)/AP-1 (zeige JUN Proteine) and ERK (zeige EPHB2 Proteine)/Runx2 (zeige RUNX2 Proteine) signaling pathways mediate TNF-alpha (zeige TNF Proteine)-dependent Smurf1 transcription.

  10. Smurf1 is a negative feedback regulator for IFN-gamma (zeige IFNG Proteine) signaling by targeting STAT1 (zeige STAT1 Proteine) for ubiquitination and proteasomal degradation.

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Interaktionspartner

  1. Data demonstrate that Smurf1 and Smurf2 (zeige SMURF2 Proteine) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

  2. In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.

SMURF1 Protein Überblick

Protein Überblick

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SMURF1

  • SMAD specific E3 ubiquitin protein ligase 1 (SMURF1)
  • SMAD specific E3 ubiquitin protein ligase 1 (LOC100220332)
  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1)
  • SMAD specific E3 ubiquitin protein ligase 1 (Smurf1)
  • 4930431E10Rik Protein
  • mKIAA1625 Protein
  • RGD1309707 Protein

Bezeichner auf Proteinebene für SMURF1

Smad ubiquitination regulatory factor 1 , E3 ubiquitin-protein ligase SMURF1 , SMAD specific E3 ubiquitin protein ligase 1 , e3 ubiquitin-protein ligase SMURF1-like , E3 ubiquitin ligase SMURF1 , SMAD-specific E3 ubiquitin-protein ligase 1 , Smad-specific E3 ubiquitin ligase 1 , hSMURF1 , SMAD ubiquitination regulatory factor 1 , xSMURF1

416487 Gallus gallus
513902 Bos taurus
608821 Canis lupus familiaris
100063241 Equus caballus
472670 Pan troglodytes
718616 Macaca mulatta
100081555 Ornithorhynchus anatinus
100220332 Taeniopygia guttata
100456599 Pongo abelii
100465094 Ailuropoda melanoleuca
100540915 Meleagris gallopavo
100556808 Anolis carolinensis
57154 Homo sapiens
75788 Mus musculus
100621443 Sus scrofa
690516 Rattus norvegicus
398131 Xenopus laevis
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