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this study identified the NRP1 (zeige NELL1 Proteine) cytoplasmic domain as essential for acute vascular hyperpermeability induced by different NRP1 (zeige NELL1 Proteine) ligands: a ligand- blocking antibody against NRP1 (zeige NELL1 Proteine) and a CendR peptide.
Data indicate that miR (zeige MLXIP Proteine)-206 inhibits neuropilin-1 (NRP1) and SMAD2 (zeige SMAD2 Proteine) gene expression by directly binding to their 3'-UTRs.
Results show that Nrp1 (zeige NELL1 Proteine) plays a critical role in balancing responsiveness to VEGF-A (zeige VEGFA Proteine) versus TGFbeta (zeige TGFB1 Proteine) to regulate glioblastoma growth, progression, and recurrence after anti-vascular therapy.
Data provide evidence that NRP1 (zeige NELL1 Proteine) functions to enhance the metastatic potential of prostate tumors.
NRP1 (zeige NELL1 Proteine) is an important niche component
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (zeige NELL1 Proteine)-dependent VEGFR (zeige KDR Proteine) signaling in PDA cells.
Our findings identify aberrant active integrin b1-driven Src (zeige SRC Proteine)-Akt (zeige AKT1 Proteine) hyperactivation as a primary resistance mechanism to cetuximab in PDAC cells and offer an effective therapeutic strategy to overcome this resistance using an EGFR (zeige EGFR Proteine) and NRP1 (zeige NELL1 Proteine) dual targeting antibody
VEGF-A (zeige VEGFA Proteine) acts via interaction with NRP-1 (zeige NELL1 Proteine) to trigger intracellular events leading to ECS cell survival and formation of aggressive, invasive and highly vascularized tumors.
These data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1 (zeige NELL1 Proteine)-IFNgamma crosstalk.
This study indicates that capsaicin application results in significant loss of epidermal NRP-1 (zeige NELL1 Proteine) receptor expression, whereas diabetic subjects presenting small fiber neuropathy show full epidermal NRP-1 (zeige NELL1 Proteine) expression in contrast to the basal expression pattern seen in healthy controls
These data suggest that both Nrp1 and Sema3a (zeige SEMA3A Proteine) are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.
Reveal a postdevelopmental role of Nrp1 in renal pericytes as an important regulator of glomerular basement membrane integrity.
Conditional Nrp1 knockout study does not support the Nrp1 model - that olfactory-derived cAMP signals, rather than direct action of olfactory receptor molecules, determine the target destinations (glomeruli) of olfactory sensory neurons in the olfactory bulb - for the anterior-posterior patterning of glomerular positions in the olfactory bulb.
It was concluded that the HFD-instigated Nrp1 reduction in macrophages exacerbates insulin (zeige INS Proteine) resistance by promoting Nlrp3 (zeige NLRP3 Proteine) inflammasome priming and activation.
findings identify a dual function of NRP1 in both axon guidance and subcellular target recognition in the construction of GABAergic circuitry.
Ectopic midline vascularisation in endothelial Nrp1 and Vegfa (zeige VEGFA Proteine)(188/188) mutants caused additional axonal exclusion zones within the chiasm.
Data suggest that Nrp1 (neuropilin-1) regulates Hedgehog (zeige SHH Proteine) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 localization to primary cilium does not correlate with Hedgehog (zeige SHH Proteine) signal promotion. These studies were conducted in various cell types. (GLI2 = GLI-Kruppel family member GLI2 protein)
These studies reported that myeloid cell-specific Nrp1-deficient mice exhibited enhanced susceptibility to cecal ligation and puncture- and LPS (zeige TLR4 Proteine)-induced sepsis, which correlated with significantly decreased survival rates and heightened levels of proinflammatory cytokines in both peritoneal lavage and serum.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR (zeige KDR Proteine) signaling in PDA cells.
VEGF165-induced vascular leakage requires both VEGFR2 (zeige KDR Proteine) and NRP1, including the VEGF164 (zeige VEGFA Proteine)-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1 (zeige GIPC1 Proteine).
Hermes (zeige RBPMS Proteine) negatively controls the translation of the guidance cue receptor Neuropilin-1 in retinal ganglion cells
Neuropilin-1 and its co-receptor plexinA1 (zeige PLXNA1 Proteine) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
binding of Neuropilin-1 to VEGFR-2 (zeige KDR Proteine) requires the PDZ-binding domain of neuropilin-1
Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors\; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
, A5 antigen
, transmembrane receptor
, vascular endothelial cell growth factor 165 receptor
, A5 protein
, Neuropilin-1 precursor (A5 protein)