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High expression of thymosin beta 10 is associated with hepatocellular carcinoma.
High expression levels of TMSB10 correlated with lymphatic metasttases in papillary thyroid carcinoma, especially in the central neck region.
Tbeta10 human recombinant proteins promoted the expression of VEGF-C (zeige VEGFC Proteine) by activating AKT (zeige AKT1 Proteine) phosphorylation in lung cancer cell lines.
Regarding HCC (zeige FAM126A Proteine), Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC (zeige FAM126A Proteine) to human cancers that express these beta-thymosins.
Low expression of Tbeta10 is associated with metastatic phenotype of CCA (zeige FBN2 Proteine) in vitro and in vivo.
The results show, for the first time, a strong expression of thymosin beta 10 in the human salivary glands during the initial phases of the physiological development, present at the 13th week of gestation, and suggesting a role for the peptide in the salivary glands' organogenesis.
Thymosin beta10 expression driven by the human TERT (zeige TERT Proteine) promoter induces ovarian cancer-specific apoptosis through ROS (zeige ROS1 Proteine) production.
Amplification of thymosin beta 10 is associated with metastatic and aggressive papillary thyroid carcinomas.
TB10 plays a critical role in the regulation of anchorage-independent growth and assembly of actin filaments.
Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures.
TMSB4 (zeige TMSB4X Proteine) and/or TMSB10 ovarian expression patterns suggest that these two thymosins may be involved in cumulus modifications during maturation.
We found an increased expression of thymosin beta-10 mRNA in thyroid carcinomas, especially in anaplastic carcinomas.
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
thymosin beta 10
, migration-inducing gene 12
, migration-inducing protein 12
, thymosin beta-10
, thymosin beta-9
, thymosin, beta 10
, prothymosin beta 10