Elastin Proteine (ELN)

Bezeichnung:
Elastin Proteine (ELN)
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Synonyme:
AI385707, AI480567, E030024M20Rik, ELN, RATTREL11, SVAS, TREL11, Trela, Trela26, WBS, WS
alle Proteine anzeigen Gen GeneID UniProt
ELN 2006 P15502
Ratte ELN ELN 25043 Q99372
ELN 13717 P54320

Weitere Synonyme anzeigen

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Weitere Proteine zu Elastin Interaktionspartnern

Human Elastin (ELN) Interaktionspartner

  1. Tropoelastin acts through a PI3K (zeige PIK3CA Proteine)-specific pathway that leads to the phosphorylation of eNOS (zeige NOS3 Proteine) to enhance nitric oxide production in endothelial cells.

  2. Deficient circumferential growth is the predominant mechanism for moderate obstructive aortic disease resulting from partial elastin deficiency in Williams syndrome.

  3. In this report we describe a three-generation family suffering from supravalvular aortic stenosis, various other arterial stenoses, sudden death, and intracranial aneurysms. A frameshift mutation in exon 12 of the elastin gene, not described before, was detected in the affected family members.

  4. Data show that skin aging is associated with the decomposition of elastin fibers, which is more pronounced in sun-exposed tissue.

  5. Transcriptional and posttranscriptional mechanisms contribute to the dysregulation of elastin expression and elastogenesis in Schimke immuno-osseous dysplasia.

  6. Neutrophil elastase (zeige ELANE Proteine) degraded elastin fragments are increased in the serum of patients with idiopathic pulmonary fibrosis and lung cancer compared to controls.

  7. Data suggest that MFAP4 (microfibrillar-associated protein 4 (zeige MFAP4 Proteine)) binds tropoelastin, fibrillin-1 (zeige FBN1 Proteine)/2, and elastin cross-linking amino acid desmosine; MFAP4 (zeige MFAP4 Proteine) co-localizes with fibrillin-1 (zeige FBN1 Proteine)-positive fibers; MFAP4 (zeige MFAP4 Proteine) actively promotes tropoelastin self-assembly.

  8. In asthma, MMP-1 (zeige MMP1 Proteine) and MMP-2 (zeige MMP2 Proteine) mediate IL-13 (zeige IL13 Proteine)-induced suppression of ELN expression in airway fibroblasts.

  9. Current knowledge about elastin peptides relevant to cardiovascular pathologies to further delineate their potential application in cardiovascular disease. [Review]

  10. elastin may be important for plaque stability

Mouse (Murine) Elastin (ELN) Interaktionspartner

  1. mTOR (zeige FRAP1 Proteine)-sensitive perturbation of smooth muscle cell mechanosensing contributes to elastin aortopathy.

  2. Deficient circumferential growth is the predominant mechanism for moderate obstructive aortic disease resulting from partial elastin deficiency in Williams syndrome.

  3. Elevations of whole lung HMGB1 (zeige HMGB1 Proteine) level were associated with impaired alveolar development and aberrant elastin production in 85% O2-exposed newborn lungs.

  4. Eln was ubiquitously present, with enrichment in regions with cardiomyocyte differentiation, while there was an inverse correlation between ColI and cardiomyocyte differentiation.

  5. Lung histology revealed aberrant elastin production and impaired lung septation in oxygen-exposed lungs, while tropoelastin, integrin alphav, fibulin-1 (zeige FBLN1 Proteine), fibulin-2 (zeige FBLN2 Proteine) and fibulin-4 (zeige FBLN4 Proteine) gene expression were elevated.

  6. Data suggest that expression of elastin in uterus, vagina, and bladder is down-regulated both in naturally aging mice and in mouse model of accelerated ovarian aging; such down-regulation may lead to pelvic floor disorders.

  7. Data indicate significantly reduced volumetric density of elastin and collagen and thinner skin dermis were observed in Marfan mice.

  8. These results suggest that elastin haploinsufficiency adversely impacts pulmonary angiogenesis.

  9. The increased levels of elastin, type V collagen and tenascin C (zeige TNC Proteine) are probably the result of increased expression by fibroblastic cells; reversely, elastin influences myofibroblast differentiation.

  10. Compared to control SMCs, the modulus of Eln-/- SMCs is reduced by 40%, but is unchanged in Fbln4 (zeige FBLN4 Proteine)-/- SMCs. The Eln-/- SMC (zeige DYM Proteine) modulus is rescued by soluble or alpha elastin treatment.

Cow (Bovine) Elastin (ELN) Interaktionspartner

  1. Data suggest that cross-linking involving desmosine and isodesmosine residues in bovine elastin and human tropoelastin contributes to long-term stability of these proteins.

  2. Immersing elastin in various glycerol-water mixtures, we observe at room temperature that the protein mobility is higher for lower glycerol fractions in the solvent and, thus, lower solvent viscosity.

  3. domain 36 of tropoelastin contributes to the binding to fibrillin-1 (zeige FBN1 Proteine) and microfibril-associated glycoprotein through two cysteine residues and Lysine-Arginine-Lysine-Arginine sequence, resulting in the promotion of elastic fiber assembly.

  4. Biaxial force-controlled experiments were used to quantify regional variations in the anisotropy and nonlinearity of elastin isolated from bovine aortic tissues proximal and distal to the heart.

  5. In cases of vascular calcification, the decreased expression of tropoelastin may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.

  6. tropoelastin has domains that mediate elastin deposition in vitro and in vivo

  7. B-Myb (zeige MYBL2 Proteine) represses SMC (zeige DYM Proteine) elastin gene expression and cyclin A (zeige CCNA2 Proteine) plays a role in the developmental regulation of elastin gene expression in the aorta

  8. self-association and oxidation by lysyl oxidase (zeige LOX Proteine) precedes tropoelastin deposition onto microfibrils; the entire molecule of tropoelastin is required for this following maturation process

  9. analysis of functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin

Pig (Porcine) Elastin (ELN) Interaktionspartner

  1. A biomechanical model of the common carotid artery predicts that the majority of elastin is in-series with vascular smooth muscle (74 +/-8%), thus only about one-fourth of elastin acts in parallel to the vascular smooth muscle within the arterial wall.

Elastin (ELN) Protein Überblick

Protein Überblick

This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Elastin (ELN)

  • elastin (ELN)
  • elastin (Tcur_2481)
  • elastin (Kfla_2289)
  • elastin (Eln)
  • elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) (ELN)
  • elastin-like (LOC100620140)
  • AI385707 Protein
  • AI480567 Protein
  • E030024M20Rik Protein
  • ELN Protein
  • RATTREL11 Protein
  • SVAS Protein
  • TREL11 Protein
  • Trela Protein
  • Trela26 Protein
  • WBS Protein
  • WS Protein

Bezeichner auf Proteinebene für Elastin Proteine (ELN)

elastin , tropoelastin , elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) , Tropoelastin

GENE ID SPEZIES
100294531 Ovis aries
463943 Pan troglodytes
574132 Macaca mulatta
8603818 Thermomonospora curvata DSM 43183
8718889 Kribbella flavida DSM 17836
2006 Homo sapiens
25043 Rattus norvegicus
13717 Mus musculus
101093909 Felis catus
101111152 Ovis aries
280781 Bos taurus
100286864 Sus scrofa
396441 Gallus gallus
100620140 Sus scrofa
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