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novel pathway for PECAM-1 regulation
PECAM-1 may not function as a major mechanoreceptor for activation of MAPK (zeige MAPK1 Proteine) and AKT (zeige AKT1 Proteine) in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals.
PECAM-1 and Fyn (zeige FYN Proteine) are essential components of a PECAM-1-based mechanosensory complex in endothelial cells
PECAM-1 plays a role in the early pathogenesis of thrombotic meningoencephalitis.
Sirt1 (zeige SIRT1 Proteine) expression is associated with CD31 (zeige HBA1 Proteine) expression in endothelial progenitor cells from patients with chronic obstructive pulmonary disease.
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin (zeige SELP Proteine) genes in the risk of recurrent IVF (zeige SCN5A Proteine)-ET failures. The coexistence of these SNPs was associated with increased IVF (zeige SCN5A Proteine)-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF (zeige SCN5A Proteine)-ET failure, especially for younger women
Dimer conformation of soluble PECAM-1
RrgA, binds both polymeric immunoglobulin receptor (pIgR (zeige PIGR Proteine)) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR (zeige PIGR Proteine)
this study shows a significant role for CD31 (zeige HBA1 Proteine) during T cell development
Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (zeige HBA1 Proteine) and VE-cadherin (zeige CDH5 Proteine), and a significant increase in that of alpha-SMA (zeige SMN1 Proteine) and collagen I.
Patients who had optic neuritis that progressed to multiple sclerosis had a decrease in serum PECAM-1 levels.
Platelet endothelial cell adhesion molecule (PECAM-1) is expressed in endothelial cells (ECs), platelets, and leukocytes, regulating the interaction between those cells.
Data indicate no association of maternal or fetal ITGA2 (zeige ITGA2 Proteine) C807T SNP, ITGB3 (zeige ITGB3 Proteine) T1565C SNP, PECAM1 CTG - GTG (zeige GGT1 Proteine) and SELP (zeige SEPP1 Proteine) A/C polymorphisms with fetal growth restriction (FGR (zeige FGR Proteine)).
these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface.
The data in this study provide evidence for the differential involvement of PECAM-1-ligand interactions in PECAM-1-dependent motility and the extension of filopodia.
Both the number of lung CD31-CD45 (zeige PTPRC Proteine)-Sca-1+ cells and the expression levels of the Shh (zeige SHH Proteine) signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh (zeige SHH Proteine) signaling pathway are reactivated during acute adenovirus infection.
In FVB/n mice, PECAM functions upstream of CD99 (zeige CD99 Proteine) in leukocyte diapedesis and blocking antibodies against either molecule arrest neutrophils before they traverse the endothelium. However, in C57BL/6 mice, PECAM and CD99 (zeige CD99 Proteine) appear to function at a different step, as the same antibodies arrest leukocyte migration through the endothelial basement membrane.
These studies indicate a role for PECAM-1 in enhancing the inhibitory functions of TGF-beta (zeige TGFB1 Proteine) in T cells
PECAM1 acts upstream of Gab1, promoting Gab1/Akt (zeige AKT1 Proteine)/eNOS (zeige NOS3 Proteine) phosphorylation and activation, thereby confers EC responsiveness to flow.
Radiation-induced stress conditions induce a transient accumulation of granulocytes within the liver by down-regulation/absence of PECAM-1.
CD31 gene transfer is sufficient to recapitulate the cytoprotective mechanisms in CD31(-) pancreatic beta cells, which become resistant to immune-mediated rejection when grafted in fully allogeneic recipients
PECAM1+ melanoma cells form vascular channels
Data indicate that in lymphocyte specific 1 (zeige LSP1 Proteine) protein (LSP1 (zeige LSP1 Proteine))-deficient mice, PECAM-1 expression was reduced in endothelial cells, but not in neutrophils.
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
platelet endothelial cell adhesion molecule
, CD31 antigen
, platelet/endothelial cell adhesion molecule (CD31 antigen)
, type I transmembrane endothelial adhesion molecule