CCL21 Proteine (CCL21)

Chemokine (C-C Motif) Ligand 21 Proteine (CCL21)
Auf finden Sie aktuell 57 Chemokine (C-C Motif) Ligand 21 (CCL21) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CCL21 Antikörper (191) und CCL21 Kits (51) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 308 CCL21 Produkte verfügbar.
6Ckine, ccl21, Ccl21b, CKb9, ECL, exodus-2, Scya21, Scya21b, Scya21c, SLC, TCA4
alle Proteine anzeigen Gen GeneID UniProt
CCL21 6366 O00585
CCL21 65956 P86792 , P86793

Weitere Synonyme anzeigen

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Am meisten referenzierte CCL21 Proteine

  1. Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927 : Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001 (PubMed)
    Zeige alle 3 Referenzen für 2002927

  2. Human CCL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666610 : Hedrick, Zlotnik: Identification and characterization of a novel beta chemokine containing six conserved cysteines. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Zeige alle 3 Referenzen für 2666610

  3. Rhesus Monkey CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2009910 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Zeige alle 2 Referenzen für 2009910

  4. Human CCL21 Protein expressed in Escherichia coli (E. coli) - ABIN667761 : Gunn, Tangemann, Tam, Cyster, Rosen, Williams: A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Zeige alle 2 Referenzen für 667761

Weitere Proteine zu CCL21 Interaktionspartnern

Human Chemokine (C-C Motif) Ligand 21 (CCL21) Interaktionspartner

  1. Results provide evidence for an association between an increase level of CCL21 and IP-10 (zeige CXCL10 Proteine) in the blood and pulmonary involvement in systemic lupus erythematosus patients.

  2. Gata1 (zeige GATA1 Proteine)-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21.

  3. CCL21 and CXCL13 (zeige CXCL13 Proteine) levels are increased in the minor salivary glands of patients with Sjogren's syndrome.

  4. Deletion of this extended C-terminus reduces CCL21's affinity for heparin and transferring the CCL21 C-terminus to CCL19 (zeige CCL19 Proteine) enhances heparin binding mainly through non-specific, electrostatic interactions

  5. CCL21/CCR7 (zeige CCR7 Proteine) interaction contributes to the time-dependent proliferation of PTC (zeige F9 Proteine) cells by upregulating cyclin A (zeige CCNA2 Proteine), cyclin B1 (zeige CCNB1 Proteine) and cyclin-dependent kinase 1 (CDK1 (zeige CDK1 Proteine)) expression via the extracellular signal-regulated kinase (ERK (zeige EPHB2 Proteine)) pathway associated with iodine.

  6. CCL21 can facilitate chemoresistance and stem cell property of colorectal cancer cells via the upregulation of P-gp (zeige ABCB4 Proteine), Bmi-1 (zeige BMI1 Proteine), Nanog (zeige NANOG Proteine), and OCT-4 (zeige POU5F1 Proteine) through AKT (zeige AKT1 Proteine)/GSK-3beta/Snail (zeige SNAI1 Proteine) signals.

  7. CCL21/CCR7 (zeige CCR7 Proteine) induce VEGF-D (zeige Figf Proteine) up-regulation and promote lymphangiogenesis via ERK (zeige EPHB2 Proteine)/Akt (zeige AKT1 Proteine) pathway in lung cancer.

  8. Our findings suggested that MUC1 (zeige MUC1 Proteine) plays an important role in CCL21-CCR7 (zeige CCR7 Proteine)-induced lymphatic metastasis and may serve as a therapeutic target in esophageal squamous cell carcinoma .

  9. TGF-beta1 (zeige TGFB1 Proteine) promoted CCL21 expression in lymphatic endothelial cells. CCL21 acted in a paracrine fashion to mediate chemotactic migration of EMT (zeige ITK Proteine) cells toward lymphatic endothelial cells.

  10. The chemotactic interaction between CCR7 (zeige CCR7 Proteine) and its ligand, CCL21, may be a critical event during progression in pancreatic cancer

Mouse (Murine) Chemokine (C-C Motif) Ligand 21 (CCL21) Interaktionspartner

  1. the CCR7 (zeige CCR7 Proteine)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (zeige FN1 Proteine) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (zeige PLCG1 Proteine)

  2. Data suggest that lymphotoxin (zeige LTB Proteine)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.

  3. CCL21 and, to a lesser extent, CCL19 (zeige CCL19 Proteine) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.

  4. CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development

  5. CXCL9 (zeige CXCL9 Proteine) has a role in graft rejection in the absence of CCL19 (zeige CCL19 Proteine) and CCL21

  6. T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (zeige LTB Proteine)(-/-) mice can be attributed to the impaired expression of CCL21.

  7. alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (zeige CCL21A Proteine) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.

  8. following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (zeige CCR7 Proteine) ligands CCL19 (zeige CCL19 Proteine)/CCL21

  9. Results suggest that CCR7 (zeige CCR7 Proteine)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.

  10. The presence of CCL21 during the in vitro stimulation of CD4 (zeige CD4 Proteine)+ T cells with anti-CD3 (zeige CD3E Proteine) plus anti-CD28 (zeige CD28 Proteine) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (zeige FASL Proteine).

CCL21 Protein Überblick

Protein Überblick

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Alternative names and synonyms associated with CCL21

  • chemokine (C-C motif) ligand 21 (CCL21)
  • CCL21 (SLC)
  • C-C motif chemokine 21 (ccl21)
  • small inducible cytokine A24 (LOC100354652)
  • chemokine (C-C motif) ligand 21C (leucine) (Ccl21c)
  • 6Ckine Protein
  • ccl21 Protein
  • Ccl21b Protein
  • CKb9 Protein
  • ECL Protein
  • exodus-2 Protein
  • Scya21 Protein
  • Scya21b Protein
  • Scya21c Protein
  • SLC Protein
  • TCA4 Protein

Bezeichner auf Proteinebene für CCL21

C-C motif chemokine 21 , CC chemokine ligand 21 , putative CCL21 chemokine , small inducible cytokine A21 , CCL21 , small inducible cytokine A24 , Efficient Chemoattractant for Lymphocytes , beta chemokine exodus-2 , secondary lymphoid tissue chemokine , small inducible cytokine subfamily A (Cys-Cys), member 21 , chemokine CCL21/6CKINE , small-inducible cytokine A21 , C-C motif chemokine 21b , C-C motif chemokine 21c , Ccl21-leu , Small-inducible cytokine A21b , beta-chemokine exodus-2 , small inducible cytokine A21c , small-inducible cytokine A21c , thymus-derived chemotactic agent 4

448796 Canis lupus familiaris
448797 Sus scrofa
511112 Bos taurus
746205 Pan troglodytes
100144337 Oryctolagus cuniculus
100196238 Salmo salar
100354652 Oryctolagus cuniculus
6366 Homo sapiens
574183 Macaca mulatta
65956 Mus musculus
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