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Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927
Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001
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CCL21/IL21 (zeige IL17C Proteine)-armed oncolytic adenovirus enhances antitumor activity against TERT (zeige TERT Proteine)-positive tumor cells.
plasmin (zeige PLG Proteine) cleaves surface-bound CCL21 to release the C-terminal peptide responsible for CCL21 binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form.
the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 (zeige CCL19 Proteine) and CCL21 was decreased.
Taken together, these results suggest that SERCA2 (zeige ATP2A2 Proteine) contributes to the migration of CCL21-activated Dendritic Cells as an important feature of the adaptive immune response and provide novel insights regarding the role of SERCA2 (zeige ATP2A2 Proteine) in Dendritic Cells functions.
An expanded lymphatic network is capable of enhanced chemoattractant CCL21 production, and lymphangiogenesis will facilitate initial lymph formation favoring increased clearance of fluid in situations of augmented fluid filtration.
Results provide evidence for an association between an increase level of CCL21 and IP-10 (zeige CXCL10 Proteine) in the blood and pulmonary involvement in systemic lupus erythematosus patients.
Gata1 (zeige GATA1 Proteine)-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21.
CCL21 and CXCL13 (zeige CXCL13 Proteine) levels are increased in the minor salivary glands of patients with Sjogren's syndrome.
Deletion of this extended C-terminus reduces CCL21's affinity for heparin and transferring the CCL21 C-terminus to CCL19 (zeige CCL19 Proteine) enhances heparin binding mainly through non-specific, electrostatic interactions
CCL21/CCR7 (zeige CCR7 Proteine) interaction contributes to the time-dependent proliferation of PTC (zeige F9 Proteine) cells by upregulating cyclin A (zeige CCNA2 Proteine), cyclin B1 (zeige CCNB1 Proteine) and cyclin-dependent kinase 1 (CDK1 (zeige CDK1 Proteine)) expression via the extracellular signal-regulated kinase (ERK (zeige EPHB2 Proteine)) pathway associated with iodine.
the CCR7 (zeige CCR7 Proteine)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (zeige FN1 Proteine) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (zeige PLCG1 Proteine)
Data suggest that lymphotoxin (zeige LTB Proteine)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.
CCL21 and, to a lesser extent, CCL19 (zeige CCL19 Proteine) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.
CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development
CXCL9 (zeige CXCL9 Proteine) has a role in graft rejection in the absence of CCL19 (zeige CCL19 Proteine) and CCL21
T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (zeige LTB Proteine)(-/-) mice can be attributed to the impaired expression of CCL21.
alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (zeige CCL21A Proteine) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.
following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (zeige CCR7 Proteine) ligands CCL19 (zeige CCL19 Proteine)/CCL21
Results suggest that CCR7 (zeige CCR7 Proteine)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.
The presence of CCL21 during the in vitro stimulation of CD4 (zeige CD4 Proteine)+ T cells with anti-CD3 (zeige CD3E Proteine) plus anti-CD28 (zeige CD28 Proteine) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (zeige FASL Proteine).
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
C-C motif chemokine 21
, CC chemokine ligand 21
, putative CCL21 chemokine
, small inducible cytokine A21
, small inducible cytokine A24
, Efficient Chemoattractant for Lymphocytes
, beta chemokine exodus-2
, secondary lymphoid tissue chemokine
, small inducible cytokine subfamily A (Cys-Cys), member 21
, chemokine CCL21/6CKINE
, small-inducible cytokine A21
, C-C motif chemokine 21b
, C-C motif chemokine 21c
, Small-inducible cytokine A21b
, beta-chemokine exodus-2
, small inducible cytokine A21c
, small-inducible cytokine A21c
, thymus-derived chemotactic agent 4