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The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
EPR (zeige EREG ELISA Kits) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase (zeige ALOX12 ELISA Kits).
Immunofluorescence analyses revealed that the ALOX15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with ALOX15-activating compounds accelerated cell death at low, but not high doses of erastin and RSL3
present in late-stage germ cells of the testis
Studied human umbilical cord mesenchymal stem cell (hucMSCs) transplantation in DSS (zeige NR0B1 ELISA Kits)-induced inflammatory bowel disease (IBD); hucMSC transplantation significantly relieved IBD symptoms thru the regulation of 15-LOX-1 expression and modulation of inflammatory responses in macrophages.
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.
Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 (zeige TP53 ELISA Kits) and stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis.
we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 (zeige CRK ELISA Kits) and LOX (zeige LOX ELISA Kits) signaling pathways, but also by decreasing the generation of ROS (zeige ROS1 ELISA Kits) and nitrate/nitrite.
15-LOX-1 re-expression downregulates the expression of MTA1 (zeige MTA1 ELISA Kits) in colorectal cancer cell lines.
The molecular origin of substrate specificity of 15-LOX-1 for linoleic acid in comparison with arachidonic acid has been analyzed.
Hypoxia increase the production of ROS (zeige ROS1 ELISA Kits) through the 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid pathway.
Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 (zeige OLR1 ELISA Kits) expression and as a new ligand for LOX-1 (zeige OLR1 ELISA Kits).
upregulation of ALOX15 occurring in response to oxidative stress in germ cells of the male mouse leads to enhanced 4-hydroxynonenal production and subsequent pathways of deleterious protein modification
The data provide the first evidence to date that small molecules that target 12/15-LOX can prevent progression of beta-cell dysfunction and glycemic deterioration in models of type 1 diabetes.
Findings suggest a pivotal role for 12/15-lipoxygenase (12/15-LOX) in both caspase (zeige CASP3 ELISA Kits)-dependent and caspase (zeige CASP3 ELISA Kits)-independent apoptotic pathways following global cerebral ischemia and suggest a novel therapeutic approach to reduce brain injury following cardiac arrest.
The present study investigated the roles of arachidonate 15-lipoxygenase (Alox15) in the clearance of dying adipocytes by adipose tissue macrophages.
data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 (zeige ICAM1 ELISA Kits) expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
This study determined that 1) deletion of 12/15-lipoxygenase (LOX) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.
12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs (zeige SMCP ELISA Kits), and 12/15-LO can mediate similar actions of TGF-beta1 (zeige TGFB1 ELISA Kits) and diabetes.
In experimental postoperative ileus, 12/15-lipoxygenase was expressed, mainly in CX3CR1 (zeige CX3CR1 ELISA Kits)(+)/Ly6C(+) infiltrating monocytes, not Ly6G(+) neutrophils. 12/15-LOX mediates ileus resolution by producing proresolving docosahexaenoic acid-derived protectin (zeige CD59 ELISA Kits) DX.
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, Arachidonate 15-lipoxygenase
, arachidonate 12-lipoxygenase, 12S-type
, arachidonate omega-6 lipoxygenase
, erythroid cell-specific 15-lipoxygenase
, omega-6 lipoxygenase
, arachidonate 12-lipoxygenase, leukocyte-type